Product image of Naproxen/Esomeprazole Abdi (Esomeprazole, Naproxen) supplied by GNH India

Naproxen/Esomeprazole Abdi

Active Ingredient:
Esomeprazole, Naproxen
Origin:
EU

Naproxen/Esomeprazole Abdi (Esomeprazole, Naproxen)

Naproxen, the active ingredient in Naproxen/Esomeprazole Abdi, is a Non‑steroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for systemic use. It reduces pain and inflammation in musculoskeletal disorders and is paired with esomeprazole to protect the stomach lining.
GNH India supplies Naproxen/Esomeprazole Abdi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Abdi Farma Gmbh

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Indications & Clinical Uses

Naproxen/Esomeprazole works on inflammatory and gastric pathways to manage pain and protect the stomach.

  • Osteoarthritis: alleviates joint pain and improves mobility.
  • Rheumatoid arthritis: reduces inflammation and joint swelling.
  • Acute musculoskeletal pain: provides short‑term relief of pain after injury or surgery.
  • NSAID‑induced ulcer prevention: lowers the risk of gastric ulceration when NSAIDs are required.

How It Works

  • Naproxen inhibits cyclo‑oxygenase‑1 and cyclo‑oxygenase‑2 enzymes, decreasing prostaglandin synthesis and thereby reducing inflammation and pain. Esomeprazole irreversibly binds to the gastric H+/K+‑ATPase pump on parietal cells, suppressing acid secretion and providing gastro‑protective effects. The combination allows effective analgesia while minimizing gastric irritation.

Side Effects

The combination may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Dyspepsia: mild stomach discomfort or indigestion.
  • Nausea: feeling of sickness often without vomiting.
  • Headache: mild to moderate pain in the head.
  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Constipation: reduced bowel movements.
  • Abdominal pain: cramping or discomfort in the stomach area.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: blood loss from the stomach or intestines.
  • Ulcer perforation: a hole in the stomach lining.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Liver enzyme elevation: signs of hepatic stress.
  • Kidney impairment: reduced renal function.
  • Stevens‑Johnson syndrome: rare severe skin reaction.

Precautions & Warnings

Before using Naproxen/Esomeprazole, consider the following safety measures.

  • Renal function assessment: evaluate kidney health, especially in elderly patients.
  • Cardiovascular risk evaluation: avoid in patients with uncontrolled hypertension or recent heart events.
  • Gastro‑intestinal monitoring: watch for signs of bleeding or ulceration.
  • Concomitant NSAID avoidance: do not combine with other NSAIDs or aspirin.
  • Hypersensitivity check: discontinue if allergic reactions occur.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Naproxen/Esomeprazole can interact with several medicines; some require avoidance while others need careful monitoring.

Major Interactions (Avoid)

  • Warfarin: increased risk of bleeding.
  • Other NSAIDs: additive gastrointestinal toxicity.
  • Corticosteroids: heightened ulcer risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: possible reduction in antihypertensive effect.
  • Methotrexate: increased methotrexate serum levels.

Frequently Asked Questions

Naproxen/Esomeprazole is prescribed to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and other acute musculoskeletal conditions. It also helps prevent stomach ulcers that can occur when NSAIDs are taken, providing a gastro‑protective effect alongside analgesia.

Naproxen blocks the cyclo‑oxygenase enzymes COX‑1 and COX‑2, which reduces the production of prostaglandins that cause pain, swelling, and fever. By lowering prostaglandin levels, naproxen diminishes inflammation and provides analgesic relief.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s condition, age, renal function, and other factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety information for pregnancy and lactation is limited. The product should only be used if the prescriber judges that the potential benefit outweighs any risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Naproxen alone provides effective pain relief but can irritate the stomach lining, especially with long‑term use. Adding esomeprazole offers gastric acid suppression, reducing the risk of ulcer formation and gastrointestinal bleeding, making the combination preferable for patients at higher GI risk.

Store the tablets at room temperature, below 25 °C, in the original container. Keep them away from moisture, heat and direct sunlight to maintain stability and potency throughout the shelf life.

The medication is taken orally, usually with a full glass of water. It can be taken with or without food, but taking it with food may reduce stomach upset. Follow the prescriber’s directions regarding timing and frequency.

Serious risks include gastrointestinal bleeding or ulcer perforation, severe allergic reactions such as anaphylaxis, liver enzyme abnormalities, and kidney impairment. Patients should seek immediate medical attention if they notice black stools, vomiting blood, rash, swelling, or sudden loss of kidney function.

Individuals with known hypersensitivity to naproxen, esomeprazole, other NSAIDs, or any component of the formulation should avoid this product. It is also contraindicated in patients with active gastrointestinal bleeding, severe heart failure, or those taking certain anticoagulants without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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