Product image of Naproxen Norfri (Naproxen) supplied by GNH India

Naproxen Norfri

Active Ingredient:
Naproxen
Origin:
EU

Naproxen Norfri (Naproxen)

Naproxen, the active ingredient in Naproxen Norfri, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for systemic use. It is employed to relieve pain, reduce inflammation, and lower fever in adult patients with various musculoskeletal and inflammatory conditions.

GNH India supplies Naproxen Norfri as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

Naproxen is an NSAID that acts on inflammatory pathways to manage several common conditions.

  • Pain: provides analgesic relief for mild to moderate acute pain.
  • Inflammation: reduces swelling associated with arthritis and soft‑tissue injuries.
  • Fever: lowers elevated body temperature in febrile states.
  • Musculoskeletal disorders: improves function and comfort in osteoarthritis, rheumatoid arthritis and related disorders.

How It Works

  • Naproxen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis diminishes peripheral sensitisation, inflammation, and the hypothalamic set‑point for temperature, thereby providing analgesic, anti‑inflammatory and antipyretic actions.

Side Effects

Adverse reactions may occur with naproxen use and are categorised by frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate tension‑type headache.
  • Dizziness: transient light‑headedness, especially on standing.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding: may present as black stools or vomiting blood.
  • Cardiovascular events: increased risk of myocardial infarction or stroke, particularly with long‑term use.
  • Renal impairment: reduced kidney function manifesting as decreased urine output or elevated creatinine.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Cardiovascular risk: assess history of heart disease or stroke before use.
  • Gastrointestinal history: avoid in patients with active ulcer disease or recent GI bleeding.
  • Renal function: monitor kidney parameters in patients with pre‑existing renal impairment.
  • Concomitant drugs: review use of anticoagulants, other NSAIDs, or corticosteroids for additive risk.
  • Pregnancy and lactation: use only if clearly indicated after professional evaluation.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Naproxen may interact with several medication classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened risk of serious bleeding.
  • Selective COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Lithium: increased lithium serum concentrations.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or diuretics: possible reduction in renal function.
  • Methotrexate: decreased clearance leading to toxicity.
  • SSRIs or SNRIs: elevated risk of upper GI bleeding.

Frequently Asked Questions

Naproxen Norfri is employed to manage mild to moderate pain, reduce inflammation in arthritis and soft‑tissue injuries, and lower fever. It is commonly prescribed for conditions such as osteoarthritis, rheumatoid arthritis, muscular sprains, and febrile illnesses.

Naproxen works by non‑selectively blocking COX‑1 and COX‑2 enzymes, which reduces the production of prostaglandins. Lower prostaglandin levels diminish inflammation, decrease pain signalling, and reset the hypothalamic temperature set‑point, providing analgesic, anti‑inflammatory and antipyretic effects.

The appropriate dose of Naproxen Norfri is determined by the prescribing healthcare professional based on the patient’s condition, age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of naproxen during pregnancy or lactation depends on the trimester and clinical necessity. It is generally avoided in the third trimester because of potential fetal complications. Breastfeeding mothers should consult a healthcare provider, as naproxen can be excreted in milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Naproxen has a longer half‑life than ibuprofen, allowing less frequent dosing for chronic conditions. Its anti‑inflammatory potency is comparable, but individual tolerance varies. All NSAIDs share similar risks of gastrointestinal, cardiovascular and renal adverse effects, so choice depends on patient‑specific factors.

Naproxen Norfri should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture, heat and direct sunlight, and ensure the packaging remains tightly closed until use.

Naproxen Norfri is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce gastrointestinal discomfort. The exact administration schedule should follow the prescriber’s directions.

The most serious risks include gastrointestinal bleeding or ulceration, cardiovascular events such as heart attack or stroke, and severe renal impairment. Patients should be monitored for signs of bleeding, chest pain, or sudden changes in urine output, and seek medical attention promptly if they occur.

Individuals with a known hypersensitivity to naproxen or other NSAIDs, active gastrointestinal ulcer disease, recent gastrointestinal bleeding, severe heart failure, or advanced renal or hepatic impairment should avoid using Naproxen Norfri. Pregnant women in the third trimester should also refrain from its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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