Naproxeno Sódico Aurovitas (Naproxen Sodium)

Naproxen sodium is an NSAID that acts on inflammatory pathways to manage several painful and febrile conditions.

• Osteoarthritis: reduces joint pain and improves mobility.
• Rheumatoid arthritis: diminishes inflammation and joint swelling.
• Acute musculoskeletal pain: provides rapid analgesia for sprains, strains and back pain.
• Fever: lowers elevated body temperature associated with infection or inflammation.
• Post‑operative pain: helps control discomfort after surgical procedures.

• Naproxen sodium exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition blocks the conversion of arachidonic acid to prostaglandins, thereby decreasing the synthesis of mediators that promote inflammation, pain, and fever at the site of tissue injury.

Adverse reactions may vary in frequency and severity.

Common Side Effects

• Gastrointestinal upset: nausea, dyspepsia or abdominal discomfort.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Rash or mild skin irritation.
• Elevated blood pressure.
• Mild renal function changes.

Serious or Rare Side Effects

• Gastrointestinal bleeding or perforation.
• Cardiovascular events such as myocardial infarction or stroke.
• Severe renal impairment or failure.
• Anaphylactic or severe allergic reactions.
• Hepatotoxicity with elevated liver enzymes.
• Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Before initiating therapy, consider the following safety measures.

• Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding.
• Evaluate cardiovascular risk: use caution in patients with known heart disease or hypertension.
• Monitor renal function: adjust use in patients with existing kidney impairment.
• Use the lowest effective dose for the shortest duration needed.
• Avoid in individuals with known hypersensitivity to naproxen or other NSAIDs.
• Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Naproxen sodium can interact with several drug classes; some require avoidance while others need close monitoring.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding risk.
• ACE inhibitors or ARBs: potential reduction in renal function.
• Lithium: elevated lithium serum concentrations.

Moderate Interactions (Monitor Closely)

• Diuretics: possible reduction in antihypertensive effect.
• Corticosteroids: increased risk of gastrointestinal ulceration.
• Methotrexate: decreased clearance leading to toxicity.
• Cyclosporine: enhanced nephrotoxic potential.
• Antihypertensive agents: may blunt blood pressure control.