Product image of Naproxeno Sódico Cinfa (Naproxen Sodium) supplied by GNH India

Naproxeno Sódico Cinfa

Active Ingredient:
Naproxen Sodium
Origin:
EU

Naproxeno Sódico Cinfa (Naproxen Sodium)

Naproxen sodium, the active ingredient in Naproxeno Sódico Cinfa, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It provides analgesic, anti‑inflammatory and antipyretic effects for mild to moderate pain and inflammatory conditions.
GNH India supplies Naproxeno Sódico Cinfa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorios Cinfa S.A.

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Indications & Clinical Uses

Naproxeno Sódico Cinfa, an NSAID, is employed in several painful and inflammatory disease states.

  • Mild to moderate pain: delivers analgesic relief for acute or chronic pain episodes.
  • Osteoarthritis: reduces joint inflammation and improves functional mobility.
  • Rheumatoid arthritis: helps control systemic inflammation and joint damage progression.
  • Musculoskeletal pain: alleviates strain‑related discomfort in muscles and tendons.
  • Dysmenorrhea: eases menstrual cramp pain and associated uterine inflammation.

How It Works

  • Naproxen sodium reversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, leading to a decrease in prostaglandin synthesis. Lower prostaglandin levels diminish peripheral sensitisation, reduce inflammatory exudate, and lower fever, thereby providing analgesic, anti‑inflammatory and antipyretic actions.

Side Effects

Adverse reactions may occur with naproxen sodium use.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash: transient erythema or pruritus.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding, which can be life‑threatening.
  • Cardiovascular events such as myocardial infarction or stroke, especially with long‑term use.
  • Acute renal impairment or worsening of chronic kidney disease.
  • Severe cutaneous reactions, including Stevens‑Johnson syndrome.
  • Hepatic injury presenting as jaundice or elevated liver enzymes.
  • Anaphylaxis: rapid onset of airway swelling, hypotension or urticaria.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Cardiovascular risk assessment: evaluate history of heart disease or stroke.
  • Gastrointestinal history: avoid in patients with active ulcer disease or recent GI bleeding.
  • Renal function monitoring: check serum creatinine in those with renal impairment.
  • Concomitant anticoagulant use: monitor coagulation parameters closely.
  • Hypersensitivity screening: discontinue if allergic reactions develop.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Naproxen sodium can alter the activity of several co‑administered medicines.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Diuretics: possible reduction in antihypertensive effect and renal perfusion.
  • Methotrexate: naproxen may raise methotrexate plasma levels, risking toxicity.
  • Corticosteroids: combined use can exacerbate ulcer formation and GI bleeding.

Frequently Asked Questions

Naproxeno Sódico Cinfa contains naproxen sodium, an NSAID indicated for relief of mild to moderate pain, reduction of inflammation in osteoarthritis and rheumatoid arthritis, management of musculoskeletal discomfort, and treatment of dysmenorrhea. It is prescribed when a non‑opioid analgesic with anti‑inflammatory properties is appropriate.

Naproxen sodium blocks the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin production, the drug reduces inflammation, pain signalling, and fever, providing its therapeutic effects across a range of painful and inflammatory conditions.

The specific dose of Naproxeno Sódico Cinfa is determined by the prescribing clinician based on the patient’s condition, age, renal and hepatic function, and other individual factors. Typical adult regimens range from 250 mg to 500 mg taken twice daily, but exact dosing must follow the prescriber’s instructions.

Naproxen sodium is generally avoided during the third trimester of pregnancy because of potential fetal cardiovascular effects, and it should be used only if clearly needed in earlier trimesters. While limited data exist for breastfeeding, the drug does pass into milk; therefore, a healthcare professional should evaluate the risk‑benefit ratio before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Both naproxen sodium and ibuprofen belong to the NSAID class, but naproxen has a longer half‑life, allowing twice‑daily dosing versus three‑ or four‑times daily for ibuprofen. Naproxen may provide more sustained pain control for chronic conditions, while ibuprofen often has a slightly lower risk of gastrointestinal irritation at standard doses.

Store the product at ambient temperature, preferably below 25 °C. Keep the tablets in their original blister pack or container, protect them from moisture, excessive heat and direct sunlight. Do not use the medication after the expiration date printed on the packaging.

Naproxeno Sódico Cinfa is taken orally with a full glass of water. It may be swallowed with or without food; however, taking it with food or milk can lessen gastrointestinal discomfort. Swallow tablets whole; do not crush, chew, or split them unless instructed by a healthcare professional.

Serious adverse events include gastrointestinal bleeding or ulceration, cardiovascular complications such as heart attack or stroke, acute kidney injury, severe skin reactions like Stevens‑Johnson syndrome, and liver injury. Patients should seek immediate medical attention if they notice black stools, chest pain, sudden swelling, rash, or jaundice.

Individuals with known hypersensitivity to naproxen or other NSAIDs, active gastrointestinal ulcer disease, recent major cardiovascular events, severe renal or hepatic impairment, and those in the third trimester of pregnancy should avoid this medication. Consultation with a healthcare provider is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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