Product image of Naproxen Sodium Marel (Naproxen Sodium) supplied by GNH India

Naproxen Sodium Marel

Active Ingredient:
Naproxen Sodium
Origin:
EU

Naproxen Sodium Marel (Naproxen Sodium)

Naproxen sodium, the active ingredient in Naproxen Sodium Marel, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is used to relieve pain, reduce inflammation, and lower fever in adults with conditions such as osteoarthritis, rheumatoid arthritis, dysmenorrhea, and other musculoskeletal disorders.

GNH India supplies Naproxen Sodium Marel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Marel B.V.

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Indications & Clinical Uses

Naproxen sodium is an NSAID that reduces inflammation and pain in several musculoskeletal and inflammatory conditions.

  • Osteoarthritis: alleviates joint pain and improves mobility.
  • Rheumatoid arthritis: decreases joint swelling and stiffness.
  • Dysmenorrhea: relieves menstrual cramp pain.
  • Acute pain: provides rapid analgesia for injuries or postoperative discomfort.
  • Fever: lowers elevated body temperature associated with inflammatory processes.

How It Works

  • Naproxen sodium exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. Reduced prostaglandin synthesis diminishes inflammation, pain signaling, and fever generation at the site of tissue injury or disease.

Side Effects

Naproxen sodium may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Mild skin rash or itching.
  • Elevated blood pressure.
  • Fluid retention leading to peripheral edema.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration.
  • Severe liver injury or hepatitis.
  • Acute kidney injury or renal failure.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Severe hypersensitivity reactions including anaphylaxis.
  • Blood disorders like thrombocytopenia or anemia.

Precautions & Warnings

Before using naproxen sodium, consider the following safety measures.

  • Assess renal function: avoid use in patients with severe kidney impairment.
  • Evaluate cardiovascular risk: use cautiously in individuals with heart disease or hypertension.
  • Monitor gastrointestinal health: patients with a history of ulcers should use protective agents.
  • Check liver status: avoid in active liver disease or elevated liver enzymes.
  • Review concomitant medications: avoid combining with other NSAIDs or anticoagulants without medical guidance.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Naproxen sodium can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Selective COX‑2 inhibitors: additive cardiovascular and gastrointestinal toxicity.
  • High‑dose aspirin: heightened gastrointestinal ulcer risk.
  • Methotrexate: reduced renal clearance leading to toxicity.
  • Lithium: NSAIDs may raise lithium serum levels.

Moderate Interactions (Monitor Closely):\n- ACE inhibitors or ARBs: may diminish antihypertensive effect and affect kidney function.

  • Diuretics: potential for reduced renal perfusion.
  • SSRIs or SNRIs: modest increase in bleeding risk.
  • Corticosteroids: enhanced gastrointestinal irritation.
  • Cyclosporine: possible nephrotoxic synergy.

Frequently Asked Questions

Naproxen Sodium Marel is indicated for the relief of mild to moderate pain, reduction of inflammation, and fever control in conditions such as osteoarthritis, rheumatoid arthritis, dysmenorrhea, and other acute musculoskeletal injuries.

Naproxen sodium works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the formation of prostaglandins—chemical mediators that promote pain, inflammation, and fever. Lower prostaglandin levels lead to decreased symptom intensity.

The appropriate dose of Naproxen Sodium Marel is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and overall health status. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of naproxen sodium during pregnancy or lactation has not been definitively established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Both naproxen sodium and ibuprofen belong to the NSAID class and share similar mechanisms of COX inhibition. Naproxen generally has a longer half‑life, allowing less frequent dosing, while ibuprofen may have a slightly faster onset. Choice depends on clinical judgment, patient tolerance, and specific therapeutic goals.

Store Naproxen Sodium Marel at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Naproxen Sodium Marel is taken orally, usually with a full glass of water. It can be taken with or without food, but taking it with food may reduce gastrointestinal discomfort. Swallow tablets whole; do not crush or chew unless specifically instructed.

Serious risks include gastrointestinal bleeding or ulceration, cardiovascular events such as heart attack or stroke, severe kidney injury, and rare but severe liver damage. Patients should be monitored for signs of these conditions and seek immediate medical attention if they occur.

Individuals with known hypersensitivity to naproxen or other NSAIDs, active gastrointestinal ulcer disease, severe heart failure, uncontrolled hypertension, or significant renal or hepatic impairment should not use Naproxen Sodium Marel unless directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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