Product image of Naproxen Sodium Marel B.V. (Naproxen Sodium) supplied by GNH India

Naproxen Sodium Marel B.V.

Active Ingredient:
Naproxen Sodium
Origin:
EU

Naproxen Sodium Marel B.V. (Naproxen Sodium)

Naproxen Sodium, the active ingredient in Naproxen Sodium Marel B.V., is a nonsteroidal anti-inflammatory drug presented as an oral tablet for oral use. It provides analgesic, anti‑inflammatory and antipyretic effects for the relief of pain, swelling and fever in adult patients.

GNH India supplies Naproxen Sodium Marel B.V. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution for this NSAID. Customers benefit from consistent product availability and comprehensive regulatory support.

Manufacturer / TM Owner

Marel B.V.

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Indications & Clinical Uses

Naproxen Sodium belongs to the NSAID class and is used to manage conditions involving pain, inflammation and fever.

  • Pain: Provides relief of mild to moderate acute pain such as headache, dental pain, or musculoskeletal discomfort.
  • Inflammation: Decreases swelling and inflammation in conditions like sprains, strains, and soft‑tissue injuries.
  • Fever: Lowers elevated body temperature associated with febrile illnesses.
  • Arthritis: Alleviates joint pain and stiffness in osteoarthritis and rheumatoid arthritis.

How It Works

  • Naproxen Sodium exerts its effect by reversibly inhibiting both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition reduces the conversion of arachidonic acid to prostaglandins, thereby decreasing the mediators responsible for pain, inflammation, and fever at the site of tissue injury.

Side Effects

Naproxen Sodium may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: dyspepsia, abdominal pain, or nausea.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Mild skin rash or itching.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding, which can be life‑threatening.
  • Renal impairment, including acute kidney injury.
  • Severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Cardiovascular events, including increased risk of myocardial infarction or stroke.

Precautions & Warnings

When using Naproxen Sodium, several precautions should be observed to minimize risk.

  • Assess renal function: evaluate baseline kidney status before initiating therapy.
  • Monitor gastrointestinal health: consider ulcer prophylaxis in high‑risk patients.
  • Check cardiovascular risk: avoid in patients with uncontrolled hypertension or recent myocardial infarction.
  • Avoid use in late pregnancy: contraindicated during the third trimester.
  • Store at ambient temperature: keep below 25 °C in the original pack, protect from moisture.

Avoid Interactions

Naproxen Sodium can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Selective COX‑2 inhibitors: additive cardiovascular risk.
  • Lithium: elevated lithium serum concentrations.
  • Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or diuretics: may impair renal function.
  • Corticosteroids: heightened gastrointestinal ulcer risk.
  • SSRIs or SNRIs: increased potential for bleeding.

Frequently Asked Questions

Naproxen Sodium is an NSAID indicated for the relief of mild to moderate pain, reduction of inflammation, and lowering of fever. It is commonly prescribed for conditions such as musculoskeletal pain, arthritis, menstrual cramps, and febrile illnesses.

The drug works by reversibly blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for prostaglandin synthesis. By lowering prostaglandin levels, it reduces the signals that cause pain, swelling, and fever at the site of injury or inflammation.

The appropriate dose of Naproxen Sodium is determined by a qualified prescriber based on the patient’s condition, age, renal function, and other clinical factors. Patients should follow the prescribing information and never adjust the dose without medical guidance.

Naproxen Sodium is generally avoided in the third trimester of pregnancy because of potential risks to the fetus. Use during the first two trimesters should only be considered if the benefit outweighs the risk and under medical supervision. Limited data are available for breastfeeding, so a healthcare professional should assess safety.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Both Naproxen Sodium and ibuprofen belong to the NSAID class and share similar mechanisms of COX inhibition. Naproxen generally has a longer half‑life, allowing less frequent dosing, while ibuprofen may have a slightly faster onset. Safety profiles are comparable, though individual patient factors may favor one over the other.

Store Naproxen Sodium at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Naproxen Sodium is administered orally, typically as a tablet or capsule that is swallowed whole with a full glass of water. It may be taken with food or milk to lessen gastrointestinal discomfort, but patients should follow the specific instructions provided by their prescriber.

Serious risks include gastrointestinal bleeding or ulceration, renal impairment, severe skin reactions such as Stevens‑Johnson syndrome, and an increased chance of cardiovascular events like heart attack or stroke, especially with long‑term or high‑dose use.

Individuals with known hypersensitivity to naproxen or other NSAIDs, those with active gastrointestinal ulcers, severe renal or hepatic impairment, uncontrolled hypertension, or in the third trimester of pregnancy should avoid Naproxen Sodium. A healthcare professional should evaluate suitability for each patient.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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