Naproxen Teva Uk (Naproxen)

Naproxen is an NSAID that reduces inflammation and pain in musculoskeletal and inflammatory conditions.

• Mild to moderate pain: provides analgesic relief for acute and chronic pain.
• Osteoarthritis: decreases joint pain and improves functional mobility.
• Rheumatoid arthritis: helps control inflammatory joint symptoms.
• Fever: reduces elevated body temperature.
• General inflammation: alleviates swelling and discomfort in various tissues.

• Naproxen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis diminishes inflammation, pain signaling, and fever generation at the site of tissue injury.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Skin rash or pruritus.
• Elevated liver enzymes.
• Mild renal function changes.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Cardiovascular events such as myocardial infarction or stroke.
• Severe renal impairment or failure.
• Anaphylactic or severe hypersensitivity reactions.
• Hepatotoxicity with marked liver enzyme elevation.
• Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Before initiating therapy, consider patient‑specific risk factors and monitor appropriately.

• Assess gastrointestinal risk: evaluate history of ulcers or bleeding.
• Review cardiovascular profile: avoid in patients with recent thrombotic events.
• Monitor renal function: especially in the elderly or those with pre‑existing kidney disease.
• Check hepatic status: periodic liver enzyme testing is advisable.
• Avoid concurrent use with other NSAIDs or anticoagulants unless medically justified.
• Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Naproxen can alter the pharmacodynamics or pharmacokinetics of several co‑administered medicines.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
• Corticosteroids: synergistic ulcerogenic effect.
• Selective serotonin reuptake inhibitors (SSRIs): elevated hemorrhage potential.
• Lithium: possible rise in serum lithium levels.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: may reduce renal perfusion.
• Diuretics: risk of renal function decline.
• Methotrexate: decreased clearance leading to toxicity.
• Antihypertensives: possible attenuation of blood pressure control.
• Digoxin: potential for increased serum concentrations.