Product image of Naproxen Zetpil Cf (Naproxen) supplied by GNH India

Naproxen Zetpil Cf

Active Ingredient:
Naproxen
Origin:
EU

Naproxen Zetpil Cf (Naproxen)

Naproxen, the active ingredient in Naproxen Zetpil Cf, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a suppository for rectal use. It treats pain, inflammation and fever in adult patients.

GNH India supplies Naproxen Zetpil Cf as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Centrafarm B.V.

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Indications & Clinical Uses

Naproxen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

  • Pain: provides analgesic relief for mild to moderate pain.
  • Inflammation: decreases swelling and tenderness in inflamed tissues.
  • Dysmenorrhea: alleviates menstrual cramps.
  • Musculoskeletal disorders: eases joint and muscle discomfort.
  • Fever: lowers elevated body temperature.

How It Works

  • Naproxen reversibly inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, leading to reduced synthesis of prostaglandins that mediate inflammation, pain and fever. This inhibition diminishes the inflammatory cascade and provides analgesic and antipyretic effects.

Side Effects

Naproxen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: mild nausea, dyspepsia, or abdominal pain.
  • Headache: transient headache episodes.
  • Dizziness: occasional light‑headedness.
  • Local irritation: rectal burning or irritation at the site of administration.
  • Diarrhea: loose stools or increased bowel movements.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding: potentially severe GI hemorrhage.
  • Cardiovascular events: increased risk of heart attack or stroke.
  • Renal impairment: reduced kidney function or acute renal failure.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatotoxicity: elevated liver enzymes or liver injury.

Precautions & Warnings

Before using Naproxen Zetpil Cf, consider the following safety measures.

  • Assess renal function: evaluate kidney health prior to therapy.
  • Monitor gastrointestinal risk: review history of ulcers or GI bleeding.
  • Check cardiovascular status: use cautiously in patients with heart disease.
  • Avoid in known hypersensitivity: do not use if allergic to NSAIDs.
  • Pregnancy and lactation: consult a healthcare provider; safety not established.
  • Store at room temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Naproxen can interact with several medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened hemorrhage risk.
  • ACE inhibitors or diuretics: may reduce renal function.
  • Lithium: increased lithium serum levels.

Moderate Interactions (Monitor Closely)

  • Methotrexate: reduced clearance, possible toxicity.
  • Corticosteroids: increased ulcer risk.
  • Cyclosporine: enhanced nephrotoxicity.
  • Diabetic medications: may affect glycemic control.
  • Alcohol: may exacerbate gastrointestinal irritation.

Frequently Asked Questions

Naproxen Zetpil Cf is a rectally administered suppository that provides analgesic, anti‑inflammatory and antipyretic effects. It is indicated for the relief of mild to moderate pain, reduction of inflammation in musculoskeletal conditions, treatment of dysmenorrhea, and lowering of fever in adult patients.

Naproxen works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are key steps in the production of prostaglandins. By reducing prostaglandin synthesis, naproxen diminishes the inflammatory response, alleviates pain signals, and helps lower elevated body temperature.

The appropriate dose of Naproxen Zetpil Cf is determined by the prescribing healthcare professional based on the patient’s condition, severity of symptoms, and individual risk factors. The prescriber will select the specific strength and frequency that best matches the therapeutic need.

Safety of naproxen during pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Naproxen has a longer half‑life than many NSAIDs such as ibuprofen, allowing less frequent dosing. Its analgesic and anti‑inflammatory potency is comparable, but the risk profile for gastrointestinal and cardiovascular events is similar across the class, requiring individual risk assessment.

Store the suppositories at room temperature, ideally below 25 °C. Keep them in the original packaging to protect from moisture and direct sunlight. Do not refrigerate or freeze, as temperature extremes can affect the suppository’s consistency.

The product is a rectal suppository. The patient should wash hands, lie on their side with the lower leg drawn toward the abdomen, gently insert the suppository into the rectum, and remain lying down for a few minutes to ensure proper absorption.

Serious risks include gastrointestinal ulceration or bleeding, cardiovascular events such as heart attack or stroke, renal impairment leading to reduced kidney function, severe skin reactions like Stevens‑Johnson syndrome, and liver injury. Patients should be monitored for any signs of these conditions.

Individuals with known hypersensitivity to naproxen or other NSAIDs, active peptic ulcer disease, severe renal or hepatic impairment, uncontrolled heart failure, or those who have experienced a recent cardiovascular event should avoid using this product. A healthcare professional should evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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