Product image of Naproxennatrium Etos (Naproxen Sodium) supplied by GNH India

Naproxennatrium Etos

Active Ingredient:
Naproxen Sodium
Origin:
EU

Naproxennatrium Etos (Naproxen Sodium)

Naproxen sodium, the active ingredient in Naproxennatrium Etos, is a nonsteroidal anti-inflammatory drug presented as an oral tablet for oral use. It is used to relieve mild to moderate pain, reduce inflammation in musculoskeletal conditions, and lower fever in adult patients.

GNH India supplies Naproxennatrium Etos as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and other healthcare facilities worldwide, with a focus on quality and regulatory compliance.

Manufacturer / TM Owner

Healthypharm B.V.

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Indications & Clinical Uses

Naproxen sodium is an NSAID that alleviates pain and inflammation in several musculoskeletal and inflammatory conditions.

  • Mild to moderate pain: provides analgesia for headaches, dental pain, and other acute pain episodes.
  • Osteoarthritis and rheumatoid arthritis: reduces joint inflammation and improves mobility.
  • Dysmenorrhea: alleviates menstrual cramps.
  • Acute gout attacks: decreases inflammation and pain associated with gout flares.
  • Post‑operative pain: helps manage pain after surgical procedures.

How It Works

  • Naproxen sodium non‑selectively inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, blocking the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes inflammation, pain signaling, and fever generation at the site of tissue injury.

Side Effects

Naproxen sodium may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort or dyspepsia.
  • Nausea or vomiting.
  • Headache.
  • Dizziness.
  • Mild skin rash.
  • Elevated blood pressure.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Acute renal impairment or failure.
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome, toxic epidermal necrolysis).
  • Hepatic injury.
  • Anaphylaxis or severe hypersensitivity reactions.

Precautions & Warnings

When prescribing naproxen sodium, clinicians should consider the following precautions.

  • Assess gastrointestinal risk: evaluate history of ulcers or bleeding.
  • Monitor cardiovascular status: avoid in patients with uncontrolled hypertension or recent myocardial infarction.
  • Check renal function: adjust in patients with impaired kidney function.
  • Avoid in late pregnancy: use only if benefits outweigh risks.
  • Review concomitant medications: especially other NSAIDs, anticoagulants, and SSRIs.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original container.

Avoid Interactions

Naproxen sodium can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.
  • Lithium: naproxen may raise lithium serum concentrations.
  • High‑dose methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: potential reduction in renal function.
  • Diuretics: may exacerbate renal impairment.
  • Corticosteroids: increased risk of gastrointestinal ulceration.
  • Beta‑blockers: possible attenuation of antihypertensive effect.
  • Cyclosporine: enhanced nephrotoxicity.

Frequently Asked Questions

Naproxennatrium Etos contains naproxen sodium, an NSAID indicated for relief of mild to moderate pain, reduction of inflammation in osteoarthritis and rheumatoid arthritis, treatment of dysmenorrhea, management of acute gout flares, and control of post‑operative pain.

Naproxen sodium blocks the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are required for prostaglandin synthesis. By lowering prostaglandin levels, it reduces inflammation, diminishes pain signaling, and helps lower fever.

The appropriate dose of Naproxennatrium Etos is determined by the prescribing clinician based on the patient’s condition, age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for naproxen sodium in pregnancy are limited, and the drug is generally avoided in the third trimester because of potential fetal cardiovascular effects. Use during breastfeeding is possible but should be discussed with a healthcare professional, as small amounts may be excreted in milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Both naproxen and ibuprofen are NSAIDs that inhibit COX enzymes, but naproxen has a longer half‑life, allowing less frequent dosing. Naproxen may carry a slightly higher risk of cardiovascular events with long‑term use, while ibuprofen is often associated with a higher incidence of gastrointestinal irritation in short‑term therapy.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children. Do not store in areas with high humidity or direct sunlight.

Naproxennatrium Etos is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce gastrointestinal discomfort. The tablet should be swallowed whole and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulceration, cardiovascular events such as heart attack or stroke, acute kidney injury, severe skin reactions (e.g., Stevens‑Johnson syndrome), and liver injury. Patients should seek immediate medical attention if they notice signs of bleeding, chest pain, sudden swelling, or severe rash.

Individuals with a known hypersensitivity to naproxen or other NSAIDs, active gastrointestinal ulceration, severe heart failure, uncontrolled hypertension, advanced renal or hepatic disease, and those in the third trimester of pregnancy should avoid using Naproxennatrium Etos unless a physician determines that benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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