Product image of Naproxeno Gp (Naproxen) supplied by GNH India

Naproxeno Gp

Active Ingredient:
Naproxen
Origin:
EU

Naproxeno Gp (Naproxen)

Naproxen, the active ingredient in Naproxeno Gp, is a nonsteroidal anti-inflammatory drug presented as an oral dosage form for oral use. It is used to relieve mild to moderate pain, reduce inflammation in conditions such as osteoarthritis and rheumatoid arthritis, and lower fever.
GNH India supplies Naproxeno Gp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gp – Genéricos Portugueses, Lda.

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Indications & Clinical Uses

  • Naproxen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.
  • Mild to moderate pain: provides analgesic relief for headaches, dental pain, and musculoskeletal discomfort.
  • Osteoarthritis and rheumatoid arthritis: decreases joint inflammation and improves mobility.
  • Dysmenorrhea: alleviates menstrual cramps and associated pain.
  • Fever: helps lower elevated body temperature.

How It Works

  • Naproxen non‑selectively inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting reduction in prostaglandin synthesis diminishes inflammation, pain signaling, and fever generation at the site of tissue injury or infection.

Side Effects

Naproxen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Mild skin rash or itching.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Renal impairment or acute kidney injury.
  • Severe hepatic dysfunction.
  • Life‑threatening skin reactions such as Stevens‑Johnson syndrome.
  • Anaphylaxis or severe hypersensitivity reactions.

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate individual risk factors and monitor for adverse events.
  • Assess renal function: avoid use in patients with severe renal impairment.
  • Monitor gastrointestinal risk: use cautiously in those with a history of ulcer disease.
  • Check cardiovascular status: NSAIDs may increase risk of thrombotic events.
  • Avoid concomitant anticoagulants: heightened bleeding risk.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Naproxen can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Selective COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Lithium: naproxen may raise lithium serum concentrations.
  • Methotrexate: potential for heightened methotrexate toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or diuretics: may reduce renal function, especially in volume‑depleted patients.
  • SSRIs or SNRIs: combined use can increase bleeding tendency.

Frequently Asked Questions

Naproxeno Gp contains naproxen, an NSAID indicated for the relief of mild to moderate pain, reduction of inflammation in osteoarthritis and rheumatoid arthritis, treatment of dysmenorrhea, and lowering of fever. It is prescribed when a non‑opioid analgesic and anti‑inflammatory effect is required.

Naproxen works by non‑selectively inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the synthesis of prostaglandins. Lower prostaglandin levels reduce inflammation, diminish pain signaling, and help normalize body temperature during fever.

The specific dose of Naproxeno Gp is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and renal or hepatic function. Dosage instructions are provided on the prescription label and should be followed exactly as directed.

Safety data for naproxen in pregnancy and lactation are limited. It is generally avoided, especially in the third trimester, because of potential fetal cardiovascular effects and reduced milk production. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the Naproxeno Gp product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Both naproxen and ibuprofen are NSAIDs that inhibit COX enzymes, but naproxen has a longer half‑life, allowing less frequent dosing, while ibuprofen is shorter‑acting. Naproxen may carry a slightly higher risk of gastrointestinal irritation, whereas ibuprofen is often preferred for short‑term use. Choice depends on clinical judgment and patient tolerance.

Naproxeno Gp should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain stability and potency throughout its shelf life.

Naproxeno Gp is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food or milk may reduce gastrointestinal discomfort. Patients should swallow tablets whole and not crush or chew them unless specifically instructed.

The most serious risks include gastrointestinal bleeding or ulcer perforation, severe cardiovascular events such as myocardial infarction or stroke, acute renal failure, severe liver injury, and rare but life‑threatening skin reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice signs of bleeding, severe abdominal pain, or skin rash.

Naproxeno Gp should be avoided in individuals with known hypersensitivity to naproxen or other NSAIDs, active peptic ulcer disease, severe renal or hepatic impairment, uncontrolled hypertension, and in the third trimester of pregnancy. It is also contraindicated in patients receiving certain anticoagulants or those with a history of serious cardiovascular events without medical supervision.

Published by

GNH India Pharmaceuticals Limited

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Last updated:

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