Product image of Naproxeno Labesfal (Naproxen) supplied by GNH India

Naproxeno Labesfal

Active Ingredient:
Naproxen
Origin:
EU

Naproxeno Labesfal (Naproxen)

Naproxen, the active ingredient in Naproxeno Labesfal, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral formulation for systemic use. It is employed to relieve pain, reduce inflammation, and lower fever in adult patients with musculoskeletal, rheumatic and menstrual conditions.

GNH India supplies Naproxeno Labesfal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Generis Farmacêutica, S.A.

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Indications & Clinical Uses

Naproxeno Labesfal, an NSAID, acts on inflammatory pathways to manage several painful and febrile conditions.

  • Pain (acute musculoskeletal pain): provides analgesic relief by decreasing prostaglandin‑mediated sensitisation of nociceptors.
  • Osteoarthritis: reduces joint inflammation and improves functional mobility.
  • Rheumatoid arthritis: helps control chronic synovial inflammation and associated pain.
  • Dysmenorrhea: alleviates menstrual cramps through uterine prostaglandin inhibition.
  • Fever: lowers elevated body temperature by acting on the hypothalamic heat‑regulation centre.

How It Works

  • Naproxen non‑selectively inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis diminishes inflammation, pain signalling, and fever generation throughout the body.

Side Effects

Naproxen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness: transient sensation of light‑headedness.
  • Rash: mild skin erythema or itching.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Severe skin reactions, including Stevens‑Johnson syndrome.
  • Renal impairment or acute kidney injury.
  • Hepatic injury presenting as jaundice or elevated liver enzymes.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess gastrointestinal risk: evaluate history of ulcers or bleeding before use.
  • Monitor renal function: check serum creatinine in patients with kidney disease.
  • Avoid in known hypersensitivity: discontinue if allergic reactions occur.
  • Use the lowest effective dose: limit duration to the shortest period necessary.
  • Caution with anticoagulants: evaluate bleeding risk when combined with warfarin or similar agents.
  • Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Naproxen can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Selective COX‑2 inhibitors: additive cardiovascular toxicity.
  • High‑dose aspirin: heightened gastrointestinal adverse effects.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or diuretics: possible reduction in renal perfusion.
  • Lithium: naproxen may raise serum lithium levels, necessitating monitoring.

Frequently Asked Questions

Naproxeno Labesfal contains naproxen, an NSAID that is commonly prescribed to treat mild to moderate pain, inflammation associated with osteoarthritis and rheumatoid arthritis, menstrual cramps (dysmenorrhea), and fever. It works by reducing the production of prostaglandins, which are chemicals that promote inflammation, pain, and elevated body temperature.

Naproxen blocks the activity of cyclo‑oxygenase enzymes COX‑1 and COX‑2, preventing the conversion of arachidonic acid into prostaglandins. Lower prostaglandin levels lead to decreased inflammation, reduced pain signalling, and a lowered fever response, providing symptomatic relief in the conditions for which it is prescribed.

The specific dose and dosing schedule of Naproxeno Labesfal are determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and overall health. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety of naproxen during pregnancy and lactation depends on the trimester and individual risk factors. Generally, NSAIDs are avoided in the third trimester because of potential fetal complications. Breastfeeding mothers should consult their physician, as naproxen can be excreted in breast milk in small amounts.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Naproxen has a longer half‑life than ibuprofen, allowing less frequent dosing for chronic conditions. Compared with selective COX‑2 inhibitors, naproxen offers broader anti‑inflammatory coverage but may carry a higher gastrointestinal risk. Choice of NSAID should be individualized based on efficacy, safety profile, and patient comorbidities.

Store Naproxeno Labesfal at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture, heat and direct sunlight, and ensure the packaging remains sealed until use to maintain stability.

Naproxeno Labesfal is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with meals may reduce gastrointestinal discomfort. Patients should swallow tablets whole and not crush or chew them unless directed by a healthcare professional.

The most serious risks include gastrointestinal bleeding or ulceration, cardiovascular events such as heart attack or stroke, severe skin reactions like Stevens‑Johnson syndrome, and renal or hepatic impairment. Patients experiencing signs of these conditions should seek immediate medical attention.

Individuals with a known hypersensitivity to naproxen or other NSAIDs, those with active gastrointestinal ulcers, severe heart failure, uncontrolled hypertension, or significant renal or hepatic disease should avoid using Naproxeno Labesfal. Pregnant women in the third trimester and patients on certain anticoagulants should also consult a physician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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