Product image of Naramig (Naratriptan) supplied by GNH India

Naramig

Active Ingredient:
Naratriptan
Origin:
EU

Naramig (Naratriptan)

Naratriptan, the active ingredient in Naramig, is a Triptan presented as an oral formulation for oral use. It selectively targets serotonin receptors to alleviate acute migraine attacks in adult patients, providing relief from headache and associated symptoms.

GNH India supplies Naramig as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and offering reliable global distribution.

Manufacturer / TM Owner

Laboratoire Glaxosmithkline

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Indications & Clinical Uses

  • Naratriptan is indicated for the acute treatment of migraine, a vascular headache disorder.
  • Acute migraine attacks: rapid relief of headache pain and associated nausea or photophobia.
  • Migraine without aura: reduction of attack severity when taken at onset.
  • Migraine with aura: alleviation of the headache phase following aura symptoms.

How It Works

  • Naratriptan acts as a selective agonist at 5‑HT1B and 5‑HT1D receptors. Activation of these serotonin receptors causes cranial blood‑vessel constriction and inhibits the release of pro‑inflammatory neuropeptides from trigeminal nerve endings, thereby interrupting the migraine cascade and reducing pain transmission.

Side Effects

Common adverse reactions to Naratriptan are generally mild and transient, while rare events may require medical attention.

Common Side Effects

  • Dry mouth
  • Drowsiness
  • Nausea
  • Chest tightness

Serious or Rare Side Effects

  • Cardiovascular events such as myocardial ischemia
  • Serotonin syndrome, especially with other serotonergic agents
  • Severe allergic reactions, including anaphylaxis

Precautions & Warnings

Before prescribing Naratriptan, clinicians should evaluate patient history and comorbid conditions.

  • Cardiovascular disease: avoid use in patients with uncontrolled hypertension or coronary artery disease.
  • History of stroke: contraindicated in individuals with prior cerebrovascular events.
  • Concomitant serotonergic drugs: risk of serotonin syndrome; monitor closely.
  • Pregnancy and lactation: safety not established; use only if benefit outweighs risk.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Naratriptan may interact with several drug classes, requiring caution.

Major Interactions (Avoid)

  • Ergot alkaloids: combined use may cause severe vasospasm.
  • MAO inhibitors: increased risk of hypertensive crisis.
  • SSRIs/SNRIs: heightened chance of serotonin syndrome.
  • Other triptans: additive vasoconstrictive effect.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may enhance hypotensive effect.
  • Antihypertensives: monitor blood pressure.
  • CYP1A2 inhibitors (e.g., fluvoxamine): may increase naratriptan plasma levels.

Frequently Asked Questions

Naramig contains the active ingredient naratriptan and is used for the acute treatment of migraine attacks. It helps relieve headache pain and associated symptoms such as nausea, photophobia, and phonophobia when taken at the onset of an episode.

Naratriptan works by selectively stimulating serotonin 5‑HT1B and 5‑HT1D receptors in the brain. This action causes constriction of dilated cranial blood vessels and blocks the release of inflammatory neuropeptides from trigeminal nerves, interrupting the migraine cascade and reducing pain.

The appropriate dose of Naramig is determined by the prescribing healthcare professional based on the patient’s clinical condition, age, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

The safety of naratriptan in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Naramig, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Naratriptan belongs to the triptan class, which is generally more specific for migraine than non‑specific analgesics. Compared with other triptans, naratriptan has a longer half‑life, allowing a single dose to cover prolonged attacks, but individual response and tolerability may vary.

Naramig tablets should be stored at ambient temperature, below 25 °C, in their original packaging to protect from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Naramig is taken orally with a glass of water. It is usually administered at the first sign of a migraine attack. Patients should swallow the tablet whole and avoid crushing or chewing it unless otherwise directed by a healthcare professional.

Serious risks include cardiovascular events such as myocardial ischemia or stroke, especially in patients with underlying vascular disease, and serotonin syndrome when combined with other serotonergic drugs. Any signs of chest pain, severe headache, or serotonin toxicity require immediate medical attention.

Naramig should not be used by individuals with uncontrolled hypertension, a history of coronary artery disease, prior stroke or transient ischemic attack, or those taking ergot alkaloids, MAO inhibitors, or other triptans. Contraindications must be confirmed by a qualified prescriber.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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