Product image of Naratriptan 1 A Pharma (Naratriptan) supplied by GNH India

Naratriptan 1 A Pharma

Active Ingredient:
Naratriptan
Origin:
EU

Naratriptan 1 A Pharma (Naratriptan)

Naratriptan, the active ingredient in Naratriptan 1 A Pharma, is a Triptan (5-HT1B/1D receptor agonist) presented as a oral tablet for oral use. It treats acute migraine attacks in adults.
GNH India supplies Naratriptan 1 A Pharma as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

1 A Pharma Gmbh

1
Pack/s
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Indications & Clinical Uses

  • Naratriptan is a selective serotonin 5‑HT1B/1D receptor agonist used in the acute treatment of migraine, a neurovascular disorder characterized by severe headache and associated symptoms.
  • Migraine (with or without aura): provides rapid relief of headache pain, nausea, photophobia and phonophobia when taken at the onset of an attack.

How It Works

  • Naratriptan binds selectively to serotonin 5‑HT1B and 5‑HT1D receptors on intracranial blood vessels and trigeminal nerve endings. Activation causes vasoconstriction of dilated cranial arteries and inhibits release of pro‑inflammatory neuropeptides, thereby aborting the migraine cascade.

Side Effects

Naratriptan may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea
  • Dizziness
  • Fatigue
  • Dry mouth
  • Paresthesia
  • Somnolence

Serious or Rare Side Effects

  • Chest pain or tightness
  • Coronary vasospasm
  • Serotonin syndrome
  • Severe hypertension
  • Allergic reactions (rash, angioedema)
  • Cardiac arrhythmias

Precautions & Warnings

Before prescribing Naratriptan, clinicians should consider several safety aspects.

  • Cardiovascular assessment: evaluate history of coronary artery disease before use.
  • Concomitant serotonergic drugs: avoid combined use due to serotonin syndrome risk.
  • Pregnancy and lactation: safety not established; use only if benefits outweigh risks.
  • Age considerations: not established in pediatric patients; use in adults only.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep below 25°C in the original pack, protect from moisture.

Avoid Interactions

Naratriptan can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Ergot alkaloids: combined use may cause severe vasospasm.
  • Monoamine oxidase inhibitors (MAOIs): increased risk of serotonin syndrome.
  • Selective serotonin reuptake inhibitors (SSRIs) and SNRIs: may increase serotonin syndrome risk.

Moderate Interactions (Monitor Closely)

  • Other triptans: additive vasoconstrictive effect.
  • CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma levels.
  • CYP3A4 inducers (e.g., rifampin): may reduce efficacy.

Frequently Asked Questions

Naratriptan 1 A Pharma is used for the acute treatment of migraine attacks in adults. It belongs to the triptan class and works by targeting serotonin receptors to relieve headache pain and associated symptoms when taken at the onset of a migraine.

Naratriptan selectively activates serotonin 5‑HT1B and 5‑HT1D receptors on cranial blood vessels and trigeminal nerve endings. This activation causes vasoconstriction of dilated intracranial arteries and blocks the release of inflammatory neuropeptides, interrupting the migraine cascade.

The appropriate dose of Naratriptan is determined by a qualified prescriber based on the patient’s clinical condition, medical history, and response to therapy. Patients should follow the dosing instructions provided by their healthcare professional.

Safety data for Naratriptan in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by the prescribing clinician in consultation with the patient.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Naratriptan is a selective 5‑HT1B/1D agonist, similar to other triptans such as sumatriptan and rizatriptan. Compared with some triptans, it has a longer half‑life and may be preferred for patients who need sustained relief, but individual response and tolerability vary.

Naratriptan tablets should be stored at ambient temperature, below 25 °C. Keep them in the original packaging, protect from moisture and direct sunlight, and keep out of reach of children.

Naratriptan is taken orally as a tablet. The tablet should be swallowed whole with water, preferably as soon as migraine symptoms begin. Patients should not crush, chew, or split the tablet unless specifically instructed by a healthcare professional.

Serious risks include chest pain or tightness, coronary vasospasm, severe hypertension, serotonin syndrome when combined with other serotonergic agents, and rare allergic reactions. Patients experiencing any of these symptoms should seek immediate medical attention.

Naratriptan should be avoided in patients with known coronary artery disease, uncontrolled hypertension, history of stroke or transient ischemic attack, severe hepatic impairment, or those taking contraindicated medications such as ergot alkaloids or MAO inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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