Naratriptan Migräne Stada (Naratriptan)

• Naratriptan is a triptan medication used in the acute treatment of migraine.
• Migraine without aura: Provides rapid relief of headache pain and associated symptoms when taken at the onset of an attack.
• Migraine with aura: Reduces the severity of headache and associated nausea after aura symptoms have begun.
• Acute migraine: Shortens the duration of a migraine episode and improves functional ability during an attack.

• Naratriptan acts as a selective agonist at serotonin 5‑HT1B and 5‑HT1D receptors located on cranial blood vessels and trigeminal nerve endings. Activation of these receptors causes vasoconstriction of dilated intracranial arteries and inhibits the release of pro‑inflammatory neuropeptides, thereby interrupting the pain signaling cascade responsible for migraine attacks.

Common Side Effects

• Nausea: Mild to moderate upset stomach.
• Dizziness: Transient sensation of light‑headedness.
• Fatigue: General feeling of tiredness.
• Dry mouth: Reduced salivation.
• Tingling or numbness: Usually in the extremities.
• Chest discomfort: Pressure or tightness in the chest.

Serious or Rare Side Effects

• Coronary vasospasm: Constriction of heart arteries.
• Severe hypertension: Marked increase in blood pressure.
• Serotonin syndrome: Potentially life‑threatening reaction when combined with other serotonergic agents.
• Allergic reactions: Rash, itching, swelling, or anaphylaxis.
• Myocardial infarction: Heart attack.
• Stroke: Cerebrovascular accident.

• Before using Naratriptan, consider the following precautions.
• Cardiovascular assessment: Evaluate history of heart disease or uncontrolled hypertension.
• Avoid in coronary artery disease: Do not use in patients with known coronary artery disease.
• Serotonergic drugs: Use caution when co‑administered with other serotonergic agents.
• Dose limits: Do not exceed the maximum recommended number of doses per month.
• Store at room temperature: Keep in the original packaging, protect from moisture and direct sunlight.

Naratriptan may interact with several medication classes.

Major Interactions (Avoid)

• Ergotamine derivatives: Combined use can cause severe vasospasm.
• Monoamine oxidase inhibitors (MAOIs): Increases risk of serotonin syndrome.
• Selective serotonin reuptake inhibitors (SSRIs) or serotonin‑norepinephrine reuptake inhibitors (SNRIs): Heightened risk of serotonin toxicity.

Moderate Interactions (Monitor Closely)

• Beta‑blockers: May enhance blood pressure‑lowering effects.
• Other triptans: Increased risk of adverse cardiovascular events.
• Antihypertensive agents: May require blood pressure monitoring.