Narine Repetabs (Loratadine, Pseudoephedrine Sulphate)

Narine Repetabs, containing loratadine and pseudoephedrine, is used to manage allergic respiratory conditions and related nasal congestion.

• Allergic rhinitis: Reduces sneezing, itching, watery eyes and nasal discharge.
• Hay fever: Provides relief from seasonal allergy symptoms including nasal blockage.
• Nasal congestion: Relieves swelling of nasal mucosa to improve airflow.
• Upper respiratory tract infection: Helps alleviate congestion associated with mild viral infections.
• Sinusitis (adjunct): Assists in decreasing nasal obstruction when used with other therapies.

• Loratadine selectively antagonizes peripheral H1 histamine receptors, preventing histamine‑mediated vasodilation, increased vascular permeability and sensory nerve stimulation. Pseudoephedrine acts as a sympathomimetic agent that stimulates α‑adrenergic receptors on nasal blood vessels, producing vasoconstriction and reduced mucosal edema, thereby improving nasal airflow. Both agents are absorbed orally and reach peak plasma concentrations within a few hours, allowing rapid symptom control.

Like all medicines, Narine Repetabs may cause unwanted reactions, which are generally classified by frequency and severity.

Common Side Effects

• Dry mouth: Reduced salivary flow causing throat discomfort.
• Headache: Mild to moderate head pain.
• Nervousness or restlessness: Feeling of agitation or jitteriness.
• Insomnia: Difficulty falling or staying asleep.
• Nausea: Upset stomach.
• Dizziness: Light‑headed sensation.
• Dry throat: Mild irritation of the throat.
• Blurred vision: Temporary visual disturbance.

Serious or Rare Side Effects

• Palpitations or tachycardia: Rapid or irregular heartbeat requiring medical attention.
• Severe hypertension: Marked increase in blood pressure.
• Allergic reaction: Rash, swelling, or anaphylaxis.
• Psychosis or hallucinations: Rare central nervous system effects.

Precautions for Narine Repetabs should be observed to minimize risk and ensure safe use.

• Contraindicated in patients with known hypersensitivity to loratadine, pseudoephedrine or any excipients: avoid administration.
• Use with caution in individuals with hypertension, cardiovascular disease, or thyroid disorders: monitor blood pressure.
• Avoid in patients taking monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuation: risk of hypertensive crisis.
• Not recommended for children under 12 years unless prescribed by a pediatric specialist: follow age‑appropriate dosing.
• Pregnant or breastfeeding women should consult a healthcare professional before use: potential risks are not fully established.
• Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Narine Repetabs can interact with other medicines; awareness of major and moderate interactions helps prevent adverse events.

Major Interactions (Avoid)

• MAO inhibitors: Concomitant use may cause severe hypertension.
• Certain antidepressants (e.g., SSRIs, SNRIs) that increase serotonergic activity: risk of serotonin syndrome.
• Other sympathomimetic decongestants (e.g., phenylephrine): may lead to excessive vasoconstriction and cardiovascular stress.

Moderate Interactions (Monitor Closely)

• Antihypertensive agents (beta‑blockers, ACE inhibitors): pseudoephedrine may reduce their efficacy.
• Antacids or acidic beverages: may affect loratadine absorption, altering effectiveness.
• CYP3A4 inhibitors (e.g., ketoconazole): could increase loratadine plasma levels.
• Alcohol: may enhance drowsiness or dizziness.