Product image of Nasenspray Sine (Xylometazoline Hydrochloride) supplied by GNH India

Nasenspray Sine

Active Ingredient:
Xylometazoline Hydrochloride
Origin:
EU

Nasenspray Sine (Xylometazoline Hydrochloride)

Xylometazoline Hydrochloride, the active ingredient in Nasenspray Sine, is an imidazoline nasal decongestant presented as a nasal spray for nasal use. It relieves nasal congestion associated with the common cold, sinusitis and allergic rhinitis in adults and children.

GNH India supplies Nasenspray Sine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Xylometazoline Hydrochloride is an imidazoline nasal decongestant that reduces swelling of the nasal mucosa.

  • Common cold: alleviates nasal blockage by shrinking swollen nasal passages.
  • Sinusitis: diminishes mucosal edema to improve sinus drainage and relieve congestion.
  • Allergic rhinitis: reduces nasal obstruction caused by allergic inflammation.

How It Works

  • Xylometazoline Hydrochloride acts as a selective alpha‑adrenergic receptor agonist on the vascular smooth muscle of the nasal mucosa. Stimulation of these receptors produces vasoconstriction, which decreases blood flow, reduces edema, and opens the nasal airway, thereby relieving congestion.

Side Effects

Adverse reactions may occur with any nasal decongestant spray.

Common Side Effects

  • Nasal irritation or burning sensation.
  • Dryness of the nasal mucosa.
  • Sneezing or mild headache.
  • Bitter taste after application.

Serious or Rare Side Effects

  • Rebound congestion (rhinitis medicamentosa) after prolonged use.
  • Severe hypertension or arrhythmia.
  • Nasal ulceration or epistaxis.
  • Allergic reactions including rash, angioedema or anaphylaxis.

Precautions & Warnings

Use Nasenspray Sine according to professional guidance and observe the following precautions.

  • Use duration: limit to 3‑5 days to avoid rebound congestion.
  • Age restrictions: not recommended for children under 2 years unless directed by a clinician.
  • Pregnancy: consult a healthcare professional before use.
  • Cardiovascular disease: employ with caution in patients with hypertension or heart disease.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Xylometazoline may interact with other sympathomimetic agents and certain cardiovascular drugs.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): may potentiate hypertensive effects.
  • Other nasal decongestants: risk of excessive vasoconstriction.
  • Sympathomimetic oral decongestants (e.g., pseudoephedrine): increased cardiovascular strain.
  • Beta‑blockers: may mask tachycardia caused by the spray.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: possible reduction in blood‑pressure control.
  • Central nervous system stimulants: monitor for heightened blood pressure.
  • Alcohol: may enhance dizziness or light‑headedness.

Frequently Asked Questions

Nasenspray Sine contains Xylometazoline Hydrochloride and is used to temporarily relieve nasal congestion caused by the common cold, sinusitis, or allergic rhinitis. It works by narrowing the blood vessels in the nasal passages, which reduces swelling and opens the airway.

Xylometazoline Hydrochloride is a selective alpha‑adrenergic agonist. By activating alpha receptors on the smooth muscle of nasal blood vessels, it causes vasoconstriction, which decreases mucosal edema and clears nasal passages, providing rapid decongestion.

The appropriate dose of Nasenspray Sine is determined by a qualified prescriber based on the patient’s age, condition, and response. Typically, a few sprays per nostril are used, but exact instructions should follow the healthcare professional’s recommendation.

Safety data for Xylometazoline Hydrochloride in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Nasenspray Sine.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Nasenspray Sine’s active ingredient, Xylometazoline, belongs to the imidazoline class, which provides rapid vasoconstriction similar to phenylephrine‑based sprays. Compared with older agents, Xylometazoline often offers a longer duration of action and may cause less rebound congestion when used within recommended limits.

Store Nasenspray Sine at room temperature, preferably below 25 °C, in its original packaging. Keep the bottle tightly closed, protect it from moisture and direct sunlight, and keep it out of reach of children.

Nasenspray Sine is applied intranasally. The user tilts the head slightly forward, inserts the nozzle into a nostril, and sprays the prescribed number of sprays while breathing in gently. The same procedure is repeated for the other nostril if required.

Serious risks include rebound nasal congestion (rhinitis medicamentosa) after prolonged use, severe hypertension, arrhythmias, nasal ulceration, and rare allergic reactions such as anaphylaxis. If any of these occur, discontinue use and seek immediate medical attention.

Individuals with known hypersensitivity to Xylometazoline or any component of the formulation should avoid Nasenspray Sine. It is also contraindicated in patients with severe hypertension, coronary artery disease, or those taking monoamine oxidase inhibitors unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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