Nasivin Zonder Conserveermiddel (Oxymetazoline Hydrochloride)

Oxymetazoline acts as a topical nasal decongestant, relieving swelling of the nasal mucosa in several common upper‑respiratory conditions.

• Common cold: reduces nasal blockage and improves airflow during viral upper‑respiratory infection.
• Allergic rhinitis: alleviates congestion caused by seasonal or perennial allergens.
• Acute sinusitis: eases nasal congestion that accompanies sinus inflammation.
• Nasal congestion due to non‑allergic rhinitis: provides short‑term relief of pressure and stuffiness.
• Post‑operative nasal swelling: helps restore nasal patency after minor ENT procedures.

• Oxymetazoline Hydrochloride selectively stimulates alpha‑1 and alpha‑2 adrenergic receptors on the smooth muscle of nasal mucosal blood vessels. This activation induces vasoconstriction, decreasing blood flow and reducing edema of the nasal lining, which opens the airway and improves breathing.

Oxymetazoline may cause local and systemic reactions, most of which are mild and transient.

Common Side Effects

• Nasal irritation or burning sensation.
• Dryness of the nasal mucosa.
• Sneezing or mild epistaxis.
• Headache.
• Bitter or metallic taste.
• Transient dizziness.

Serious or Rare Side Effects

• Rebound nasal congestion (rhinitis medicamentosa) with prolonged use.
• Elevated blood pressure or hypertension.
• Tachycardia or arrhythmias.
• Severe nasal ulceration or necrosis.
• Cardiac palpitations.
• Rare allergic reactions such as rash or angioedema.

Before using Nasivin Zonder Conserveermiddel, consider the following safety measures.

• Use in children under 6 years: not recommended unless directed by a healthcare professional.
• Avoid prolonged use: limit application to no more than three consecutive days to prevent rebound congestion.
• Hypertension or cardiovascular disease: consult a physician before use.
• Concomitant sympathomimetic drugs: use with caution and under medical advice.
• Pregnancy and breastfeeding: safety not established; discuss risks with a healthcare provider.
• Store at room temperature: keep in the original container, protect from moisture and direct heat.

Oxymetazoline may interact with other medications that affect the sympathetic nervous system.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): risk of excessive vasoconstriction.
• Other nasal decongestants (e.g., phenylephrine): additive vasoconstrictive effect.
• Systemic sympathomimetics (e.g., pseudoephedrine): may cause severe hypertension.

Moderate Interactions (Monitor Closely)

• Beta‑blockers: possible attenuation of cardiovascular effects.
• Lithium: may increase lithium levels; monitor serum concentrations.