Nasofan Aqueous (Fluticasone Propionate)

• Fluticasone Propionate nasal spray is used to treat inflammatory conditions of the nasal passages and sinuses.
• Allergic rhinitis: reduces nasal congestion, itching, sneezing and rhinorrhea caused by allergic inflammation.
• Nasal polyps: decreases polyp size and improves nasal airflow, helping to control symptoms and reduce the need for surgery.
• Sinusitis: alleviates nasal inflammation and promotes drainage in chronic sinusitis, supporting symptom relief.

• Fluticasone Propionate is a synthetic glucocorticoid that penetrates nasal mucosal cells and binds to intracellular glucocorticoid receptors. The drug‑receptor complex translocates to the nucleus, where it modulates gene transcription, suppressing pro‑inflammatory cytokines and mediators, thereby reducing vascular permeability, edema, and inflammatory cell infiltration in the nasal passages.

Fluticasone Propionate nasal spray may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

• Nasal irritation or burning sensation
• Epistaxis (nosebleed)
• Headache
• Throat irritation or dryness
• Cough
• Altered taste or smell

Serious or Rare Side Effects

• Nasal septal perforation
• Adrenal suppression with prolonged high‑dose use
• Glaucoma or cataract progression
• Severe allergic reaction (anaphylaxis)
• Opportunistic fungal infection of the nasal mucosa

• Before using Fluticasone Propionate nasal spray, consider the following safety measures.
• Pregnancy: consult a healthcare provider; limited safety data are available.
• Pediatric use: safety established for children aged 2 years and older; follow prescriber guidance.
• Concurrent infection: avoid use if an active nasal or sinus infection is present unless directed by a clinician.
• Surgery: discontinue several days before nasal or sinus surgery to reduce bleeding risk.
• Systemic corticosteroid effects: monitor for signs of adrenal suppression with prolonged high‑dose therapy.
• Store at room temperature: keep below 25 °C, protect from moisture and light in the original container.

Fluticasone Propionate nasal spray can interact with other medicines; some combinations require avoidance while others need monitoring.

Major Interactions (Avoid)

• Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic exposure and risk of adrenal suppression.
• Systemic corticosteroids: additive glucocorticoid effects may increase systemic side‑effects.

Moderate Interactions (Monitor Closely)

• Moderate CYP3A4 inhibitors (e.g., ritonavir, certain antiretrovirals): may modestly raise exposure.
• Antihistamines: may enhance local antihistaminic effect but no significant interaction.
• Live attenuated nasal vaccines: efficacy may be reduced; consider timing of administration.