Nasofan Aqueous (Fluticasone Propionate)

• Fluticasone Propionate nasal spray acts on the inflammatory cascade that underlies allergic rhinitis, providing symptom control across several related conditions.
• Allergic rhinitis: reduces nasal congestion, sneezing, itching and rhinorrhoea.
• Seasonal allergic rhinitis: alleviates symptoms triggered by pollen or other seasonal allergens.
• Perennial allergic rhinitis: controls year‑round nasal inflammation caused by indoor allergens such as dust mites or pet dander.

• Fluticasone Propionate is a synthetic glucocorticoid that penetrates nasal mucosal cells and binds to intracellular glucocorticoid receptors. The receptor complex then translocates to the nucleus, where it suppresses transcription of pro‑inflammatory cytokines, chemokines and adhesion molecules, leading to decreased vascular permeability, reduced mucosal edema and inhibition of the allergic response.

Adverse reactions are generally local to the nasal cavity, but systemic effects can occur with excessive use.

Common Side Effects

• Nasal irritation or burning sensation
• Dryness of nasal passages
• Epistaxis (nosebleeds)
• Headache
• Altered taste or bitter taste
• Throat irritation or cough

Serious or Rare Side Effects

• Nasal septal perforation
• Severe allergic reaction (anaphylaxis)
• Vision changes such as cataracts or glaucoma
• Adrenal suppression with prolonged high‑dose use
• Opportunistic fungal infection of the nasal mucosa

Before initiating therapy, consider the following safety measures.

• Hypersensitivity: avoid use in patients with known allergy to fluticasone or any excipients.
• Recent nasal surgery or trauma: postpone treatment until healing is complete.
• Caution in children: monitor growth and systemic exposure.
• Concomitant systemic steroids: assess risk of additive glucocorticoid effects.
• Do not use with other intranasal corticosteroids unless directed by a physician.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Fluticasone Propionate may interact with other medicines that affect steroid metabolism or immune response.

Major Interactions (Avoid)

• Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) – may increase systemic exposure.
• Systemic corticosteroids – risk of additive glucocorticoid side effects.
• Live vaccines – potential reduction in vaccine efficacy.

Moderate Interactions (Monitor Closely)

• Moderate CYP3A4 inhibitors (e.g., erythromycin) – may modestly raise fluticasone levels.
• Ritonavir or other protease inhibitors – require monitoring for systemic effects.
• Other intranasal decongestants – may increase local irritation or dryness.