Product image of Nasofan (Fluticasone Propionate) supplied by GNH India

Nasofan

Active Ingredient:
Fluticasone Propionate
Origin:
EU

Nasofan (Fluticasone Propionate)

Fluticasone Propionate, the active ingredient in Nasofan, is a corticosteroid presented as a nasal spray for endosinusial use. It is indicated for inflammatory conditions of the nasal passages such as allergic rhinitis, nasal polyps and chronic sinusitis, helping to reduce swelling and symptom severity.
GNH India supplies Nasofan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Sweden Ab

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Indications & Clinical Uses

  • Fluticasone Propionate acts locally in the nasal mucosa to control inflammation associated with several upper‑respiratory conditions.
  • Allergic rhinitis: reduces nasal congestion, itching and sneezing caused by allergen exposure.
  • Nasal polyps: decreases polyp size and improves nasal airflow.
  • Chronic sinusitis: alleviates mucosal swelling and promotes sinus drainage.

How It Works

  • Fluticasone Propionate binds to intracellular glucocorticoid receptors in nasal epithelial cells, forming a complex that translocates to the nucleus and modulates gene transcription. This action suppresses the production of pro‑inflammatory cytokines, chemokines and adhesion molecules, leading to reduced vascular permeability, edema and immune cell infiltration in the nasal mucosa.

Side Effects

Fluticasone Propionate is generally well tolerated when used as directed, but local and systemic adverse reactions can occur.

Common Side Effects

  • Nasal irritation or burning sensation
  • Epistaxis (nosebleeds)
  • Headache
  • Sore throat or cough
  • Altered taste or oral dryness
  • Sneezing shortly after administration

Serious or Rare Side Effects

  • Adrenal suppression with prolonged high‑dose use
  • Development of cataracts or glaucoma
  • Fungal infection of the nasal passages
  • Severe or persistent nosebleeds
  • Hypersensitivity reactions such as angioedema

Precautions & Warnings

  • Before using Nasofan, consider the following safety measures.
  • Prescribe only as needed: avoid unnecessary long‑term use.
  • Monitor for infection: discontinue if signs of fungal or bacterial infection appear.
  • Assess ocular health: patients with glaucoma or cataracts should use with caution.
  • Check systemic exposure: patients on systemic steroids may have increased risk of systemic effects.
  • Evaluate metabolic conditions: diabetics should monitor blood glucose as corticosteroids can affect glucose control.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Fluticasone Propionate may interact with other medications that influence corticosteroid metabolism or systemic exposure.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) that can increase systemic levels.
  • Concurrent systemic corticosteroids, raising risk of systemic side effects.
  • Ritonavir or other potent protease inhibitors that markedly inhibit metabolism.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., erythromycin) may modestly raise exposure.
  • Antifungal agents such as fluconazole.
  • Certain antiretroviral drugs (e.g., efavirenz) that may alter steroid clearance.

Frequently Asked Questions

Nasofan contains fluticasone propionate and is prescribed for inflammatory nasal conditions such as allergic rhinitis, nasal polyps and chronic sinusitis. By reducing local inflammation, it helps relieve congestion, itching, sneezing and improves overall nasal airflow.

Fluticasone propionate binds to glucocorticoid receptors in the cells lining the nasal passages. This complex alters gene expression, suppressing the release of inflammatory cytokines and mediators, which decreases swelling, mucus production and immune cell activity in the nasal mucosa.

The specific dosing regimen for Nasofan is determined by the prescribing healthcare professional based on the patient’s condition, severity and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for fluticasone propionate in pregnancy and lactation are limited. Healthcare providers usually weigh potential benefits against possible risks before prescribing. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their doctor.

To request Nasofan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Nasofan’s active ingredient, fluticasone propionate, is a high‑potency intranasal corticosteroid with minimal systemic absorption compared with some older agents. Its efficacy in reducing nasal inflammation is comparable to other modern nasal steroids, while its safety profile is favorable when used at recommended doses.

Nasofan should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid freezing. Do not use the product if the seal is broken or the spray appears discolored.

Nasofan is a nasal spray intended for endosinusial use. The patient should gently blow the nose, tilt the head slightly forward, insert the nozzle into one nostril, and spray the prescribed number of sprays while breathing in gently. The process is repeated in the other nostril if directed.

Serious but rare risks include adrenal suppression, especially with prolonged high‑dose use, and ocular complications such as cataracts or glaucoma. Patients should report persistent nosebleeds, visual changes, severe headaches or signs of infection to their healthcare provider promptly.

Nasofan is contraindicated in individuals with known hypersensitivity to fluticasone propionate or any component of the formulation. It should also be avoided in patients with untreated fungal infections of the nasal passages or those who have experienced severe adverse reactions to other intranasal corticosteroids.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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