Product image of Nasofan (Fluticasone Propionate) supplied by GNH India

Nasofan

Active Ingredient:
Fluticasone Propionate
Origin:
EU

Nasofan (Fluticasone Propionate)

Fluticasone Propionate, the active ingredient in Nasofan, is a corticosteroid presented as a nasal spray for endosinusial use. It reduces nasal inflammation through local glucocorticoid activity and alleviates symptoms of allergic rhinitis and other nasal inflammatory disorders in both adults and children seasonally worldwide effectively.

GNH India supplies Nasofan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution, ensuring product integrity from manufacture to end‑user.

Manufacturer / TM Owner

Teva Czech Industries S.R.O

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Indications & Clinical Uses

Fluticasone Propionate nasal glucocorticoid acts locally on the nasal mucosa to control inflammatory conditions.

  • Allergic rhinitis: reduces nasal congestion, sneezing, itching and rhinorrhoea associated with seasonal or perennial allergies.
  • Nasal polyposis: helps shrink polyps and improves nasal airflow in patients with chronic sinus disease.
  • Non‑allergic rhinitis: alleviates nasal irritation and discharge caused by irritant or vasomotor triggers.

How It Works

  • Fluticasone propionate binds to intracellular glucocorticoid receptors in nasal epithelial cells, altering gene transcription to suppress pro‑inflammatory cytokine production, inhibit mast cell degranulation, and reduce vascular permeability, thereby decreasing swelling and mucus formation in the nasal mucosa.

Side Effects

Fluticasone propionate is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nasal irritation or burning sensation.
  • Epistaxis (nosebleeds).
  • Headache.
  • Sore throat or hoarseness.
  • Altered taste or smell.

Serious or Rare Side Effects

  • Adrenal suppression with prolonged high‑dose use.
  • Cataract formation or glaucoma.
  • Severe allergic reaction (anaphylaxis).
  • Opportunistic fungal infection of the nasal passages.
  • Nasal septum perforation (very rare).

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Assess for active nasal infection: avoid use until infection resolves.
  • Hypersensitivity: discontinue if patient shows allergic reaction to fluticasone or formulation components.
  • Use lowest effective dose: limit exposure to reduce systemic absorption.
  • Monitor for signs of adrenal suppression, especially with long‑term or high‑dose therapy.
  • Avoid abrupt discontinuation: taper if therapy has been prolonged.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Fluticasone propionate may interact with other medicines that affect corticosteroid metabolism or systemic effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic exposure and risk of adrenal suppression.
  • Concurrent systemic corticosteroids: additive effect on hypothalamic‑pituitary‑adrenal axis.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., erythromycin, ritonavir): may modestly raise fluticasone levels.
  • Antifungal azoles (e.g., fluconazole): monitor for increased local effects.
  • Live vaccines: efficacy may be reduced; consider timing of vaccination.

Frequently Asked Questions

Nasofan contains fluticasone propionate, a nasal glucocorticoid indicated for the treatment of allergic rhinitis, nasal polyposis and other inflammatory conditions of the nasal passages. It works locally to relieve congestion, sneezing, itching and nasal discharge.

Fluticasone propionate binds to glucocorticoid receptors inside nasal mucosal cells, modifying gene transcription to suppress the release of inflammatory cytokines, reduce vascular permeability, and inhibit mast‑cell activation. This anti‑inflammatory action decreases swelling and mucus production in the nose.

The prescribed dose of Nasofan is determined by the treating clinician based on the patient’s age, severity of symptoms and response to therapy. The prescriber will provide specific instructions on the number of sprays per nostril and the frequency of use.

Safety data for fluticasone propionate in pregnancy and lactation are limited. Healthcare providers generally weigh the potential benefits against any possible risks before prescribing. Patients should discuss their individual situation with a qualified medical professional.

To order Nasofan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nasofan’s active ingredient, fluticasone propionate, is a high‑potency corticosteroid with minimal systemic absorption when used as directed. Compared with older agents such as beclomethasone, it often provides stronger local anti‑inflammatory effects with a lower risk of systemic side effects at equivalent doses.

Nasofan should be stored at room temperature, below 25 °C, in its original packaging. Keep the device away from moisture, heat and direct sunlight. Do not freeze the product, and ensure the spray tip remains clean to maintain dose accuracy.

Nasofan is administered as a nasal spray. The patient gently shakes the bottle, primes the spray if required, tilts the head slightly forward, inserts the nozzle into one nostril, and delivers the prescribed number of sprays while breathing in gently. The process is repeated in the other nostril if directed.

Serious risks, though uncommon, include adrenal suppression with prolonged high‑dose use, cataract or glaucoma development, severe allergic reactions (anaphylaxis), and opportunistic fungal infections of the nasal mucosa. Patients should report persistent nosebleeds, visual changes or signs of systemic steroid effects to their clinician.

Nasofan should be avoided in individuals with known hypersensitivity to fluticasone propionate or any component of the formulation. It is also contraindicated in patients with active untreated nasal infections, recent nasal surgery or trauma, and in those for whom systemic corticosteroid exposure is contraindicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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