Product image of Nasofan (Fluticasone Propionate) supplied by GNH India

Nasofan

Active Ingredient:
Fluticasone Propionate
Origin:
EU

Nasofan (Fluticasone Propionate)

Fluticasone Propionate, the active ingredient in Nasofan, is a corticosteroid (glucocorticoid) presented as a nasal spray for endosinusial use. It reduces nasal inflammation associated with allergic rhinitis and nasal polyps, providing symptomatic relief in adults and children.

GNH India supplies Nasofan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing and regulatory support for global distribution. Our quality‑assured manufacturing follows EU GMP standards, and we maintain appropriate logistics to ensure product integrity throughout the supply chain.

Manufacturer / TM Owner

Norton Healthcare Ltd T/A Ivax Pharmaceuticals Uk

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Indications & Clinical Uses

Fluticasone Propionate acts locally in the nasal mucosa to control inflammation in several upper‑respiratory conditions.

  • Allergic rhinitis (seasonal): reduces sneezing, itching and nasal congestion.
  • Allergic rhinitis (perennial): alleviates chronic nasal discharge and obstruction.
  • Nasal polyps: decreases polyp size and improves airflow, helping to control symptoms.

How It Works

  • Fluticasone Propionate binds to intracellular glucocorticoid receptors in nasal epithelial cells, altering gene transcription. This down‑regulates pro‑inflammatory cytokines, chemokines and adhesion molecules, thereby suppressing inflammatory cell recruitment and reducing mucosal edema and hypersecretion.

Side Effects

Fluticasone Propionate may cause local and systemic adverse reactions.

Common Side Effects

  • Nasal irritation or burning sensation.
  • Epistaxis (nosebleeds).
  • Headache.
  • Sore throat or cough.
  • Altered taste or oral dryness.

Serious or Rare Side Effects

  • Nasal septal perforation.
  • Adrenal suppression with prolonged high‑dose use.
  • Cataracts or glaucoma.
  • Severe allergic reaction (anaphylaxis).

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess for active nasal infection: avoid use during acute bacterial or fungal sinusitis.
  • Hypersensitivity: discontinue if patient shows allergy to fluticasone or other corticosteroids.
  • Use lowest effective dose: limit exposure to reduce systemic absorption.
  • Monitor long‑term therapy: watch for signs of adrenal insufficiency or intra‑ocular pressure rise.
  • Avoid abrupt discontinuation after extended high‑dose treatment: taper if needed.
  • Store at room temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Fluticasone Propionate can interact with other medicines that affect corticosteroid metabolism or add glucocorticoid effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic exposure.
  • Systemic corticosteroids: additive glucocorticoid effects can raise risk of adrenal suppression.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., erythromycin, ritonavir): may modestly raise exposure.
  • Antifungal azoles (except strong inhibitors): potential for increased levels.
  • Live vaccines: possible reduced vaccine efficacy.

Frequently Asked Questions

Nasofan contains fluticasone propionate, a nasal corticosteroid indicated for managing allergic rhinitis—both seasonal and perennial forms—and for reducing the size of nasal polyps, helping to improve nasal airflow and relieve associated symptoms.

Fluticasone propionate binds to glucocorticoid receptors in nasal mucosal cells, modulating gene expression to suppress the release of inflammatory cytokines and chemokines. This reduces inflammatory cell infiltration, edema, and mucus production, leading to symptom relief.

The prescribed dose of Nasofan is determined by the treating clinician based on the patient’s age, severity of symptoms, and response to therapy. Dosage instructions are provided on the product label and should be followed exactly as directed by a healthcare professional.

Safety data for fluticasone propionate in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the prescribing physician.

To place an order, submit an enquiry on the Nasofan product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nasofan’s active ingredient, fluticasone propionate, is a high‑potency glucocorticoid with low systemic bioavailability, similar to other prescription nasal steroids such as mometasone furoate. Clinical efficacy and safety profiles are comparable, but individual response and tolerability may vary.

Store Nasofan at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid freezing to maintain product stability.

Nasofan is delivered as a nasal spray. The patient should gently blow the nose, tilt the head slightly forward, insert the nozzle into one nostril, and spray the prescribed number of actuations while breathing in gently. The process is repeated in the other nostril if required.

Serious risks, though rare, include nasal septal perforation, adrenal suppression with prolonged high‑dose use, cataract formation, glaucoma, and severe allergic reactions such as anaphylaxis. Patients should be monitored for these events, especially during long‑term therapy.

Nasofan should be avoided in individuals with known hypersensitivity to fluticasone propionate or any component of the formulation, and in patients with active untreated nasal infections. Caution is also advised for those with uncontrolled glaucoma, cataracts, or systemic conditions that could be worsened by corticosteroids.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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