Product image of Nasofan (Fluticasone Propionate) supplied by GNH India

Nasofan

Active Ingredient:
Fluticasone Propionate
Origin:
EU

Nasofan (Fluticasone Propionate)

Fluticasone Propionate, the active ingredient in Nasofan, is a corticosteroid (glucocorticoid) presented as a nasal spray for nasal use. It treats allergic inflammation of the nasal passages in adults and children with allergic rhinitis or nasal polyps.

GNH India supplies Nasofan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Fluticasone Propionate nasal spray acts on inflammatory pathways of the nasal mucosa to relieve allergic symptoms.

  • Allergic rhinitis: reduces nasal congestion, itching, sneezing and rhinorrhea.
  • Seasonal allergic rhinitis: controls symptoms triggered by pollen or other seasonal allergens.
  • Perennial allergic rhinitis: provides year‑round relief from indoor allergen‑induced symptoms.
  • Nasal polyps: helps shrink polyps and improves nasal airflow.

How It Works

  • Fluticasone propionate binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and inhibits transcription of pro‑inflammatory cytokines. This reduces inflammatory cell migration and edema in the nasal mucosa, leading to decreased swelling and mucus production.

Side Effects

Fluticasone propionate may cause local and systemic adverse reactions.

Common Side Effects

  • Nasal irritation or burning sensation.
  • Epistaxis (nosebleeds).
  • Headache.
  • Sore throat.
  • Cough.
  • Altered taste or oral dryness.

Serious or Rare Side Effects

  • Adrenal suppression with prolonged high‑dose use.
  • Glaucoma or cataract formation.
  • Severe nasal septum perforation.
  • Opportunistic fungal infection of the nasal cavity.
  • Systemic immunosuppression leading to increased infection risk.
  • Hypersensitivity reactions including angioedema.

Precautions & Warnings

Before using Nasofan, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Pediatric use: follow age‑appropriate dosing guidelines.
  • Abrupt discontinuation: taper if long‑term therapy is stopped to avoid rebound inflammation.
  • Ocular monitoring: watch for signs of glaucoma or cataracts.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Fluticasone propionate can interact with other medicines; awareness helps minimize risk.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic exposure.
  • Live vaccines: reduced efficacy and potential infection risk.

Moderate Interactions (Monitor Closely)

  • Systemic corticosteroids: additive glucocorticoid effects.
  • Antifungal agents (e.g., fluconazole): may raise fluticasone levels.
  • Protease inhibitors (e.g., ritonavir): potential increase in exposure.

Frequently Asked Questions

Nasofan is a nasal spray containing fluticasone propionate and is indicated for the management of allergic rhinitis (both seasonal and perennial) and for reducing the size of nasal polyps. It works by decreasing inflammation in the nasal passages, helping to relieve congestion, sneezing, itching, and runny nose.

Fluticasone propionate is a synthetic glucocorticoid that binds to glucocorticoid receptors in nasal mucosal cells. The drug‑receptor complex then modulates gene expression, suppressing the production of pro‑inflammatory cytokines and limiting the migration of inflammatory cells, which reduces swelling and mucus formation in the nose.

The exact dosing regimen for Nasofan is determined by the prescribing clinician based on the patient’s age, severity of symptoms, and response to therapy. Typically, one or two sprays per nostril once or twice daily are used, but the prescriber will provide the specific instructions for each individual.

Safety data for fluticasone propionate in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before starting Nasofan.

To order Nasofan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Nasofan contains fluticasone propionate, which is among the most potent topical glucocorticoids for nasal use. Compared with older agents such as beclomethasone or budesonide, fluticasone offers a higher receptor affinity and a lower systemic absorption profile, often resulting in effective symptom control with a reduced risk of systemic side effects.

Nasofan should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from moisture and direct sunlight, and avoid freezing. Do not use the product after the expiry date printed on the packaging.

Nasofan is administered as a nasal spray. The user should gently blow the nose, tilt the head slightly forward, insert the nozzle into one nostril, and press the actuator while breathing in gently through the nose. The same procedure is repeated for the other nostril if required.

Serious risks, though uncommon, include adrenal suppression with prolonged high‑dose use, development of glaucoma or cataracts, severe nasal septum perforation, and opportunistic fungal infections of the nasal cavity. Patients should report persistent nosebleeds, visual changes, severe facial pain, or signs of infection to a healthcare professional promptly.

Nasofan should be avoided in individuals with known hypersensitivity to fluticasone propionate or any component of the formulation. It is also contraindicated in patients with active untreated fungal, bacterial, or viral infections of the nasal passages, and in those for whom systemic corticosteroid therapy is contraindicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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