Product image of Nasofan (Fluticasone Propionate) supplied by GNH India

Nasofan

Active Ingredient:
Fluticasone Propionate
Origin:
EU

Nasofan (Fluticasone Propionate)

Fluticasone Propionate, the active ingredient in Nasofan, is a corticosteroid presented as a nasal spray for nasal use. It reduces inflammation in the nasal passages and is indicated for conditions such as allergic rhinitis and nasal polyps.

GNH India supplies Nasofan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Sweden Ab

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Indications & Clinical Uses

Fluticasone Propionate is used in the management of inflammatory nasal disorders, acting on the mucosal immune response.

  • Allergic rhinitis: alleviates nasal congestion, itching and sneezing caused by allergens.
  • Seasonal allergic rhinitis: provides symptom relief during pollen seasons.
  • Nasal polyps: reduces polyp size and improves nasal airflow.

How It Works

  • Fluticasone Propionate binds to intracellular glucocorticoid receptors in nasal mucosal cells, forming a complex that translocates to the nucleus and modulates gene transcription. This action suppresses the production of inflammatory cytokines, chemokines, and adhesion molecules, thereby decreasing vascular permeability, edema, and leukocyte infiltration in the nasal lining.

Side Effects

Fluticasone Propionate may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nasal irritation or burning sensation
  • Epistaxis (nosebleeds)
  • Headache
  • Altered taste or mouth dryness
  • Throat irritation
  • Cough

Serious or Rare Side Effects

  • Adrenal suppression with prolonged high‑dose use
  • Cataracts or glaucoma development
  • Fungal infection of the nasal passages
  • Severe allergic reaction (anaphylaxis)
  • Nasal septal perforation
  • Vision changes requiring ophthalmologic evaluation

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor for potential complications.

  • Assess for active nasal infection: avoid use until infection resolves.
  • Avoid in children under 2 years: safety not established.
  • Monitor for signs of adrenal suppression during long‑term therapy.
  • Use with caution in patients with glaucoma or cataracts.
  • Do not discontinue abruptly after prolonged use: taper as advised.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Fluticasone Propionate can interact with other medicines that affect corticosteroid metabolism or systemic exposure.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic corticosteroid levels.
  • Ritonavir or other protease inhibitors: can elevate fluticasone exposure.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, phenytoin): may reduce efficacy.
  • Systemic corticosteroids: additive systemic effects.
  • Antifungal agents (e.g., fluconazole): may modestly increase exposure.

Frequently Asked Questions

Nasofan contains fluticasone propionate, a nasal corticosteroid indicated for the relief of symptoms associated with allergic rhinitis and for the reduction of size and recurrence of nasal polyps. It works by decreasing inflammation in the nasal mucosa.

Fluticasone propionate binds to glucocorticoid receptors in nasal epithelial cells, altering gene transcription to suppress inflammatory cytokines, chemokines, and other mediators. This reduces swelling, mucus production, and immune cell infiltration, leading to improved nasal airflow and symptom control.

The prescribed dose of Nasofan is determined by the treating clinician based on the patient’s age, severity of symptoms, and response to therapy. The prescriber will provide specific instructions on the number of sprays per nostril and the frequency of administration.

Safety data for fluticasone propionate in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To request Nasofan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Nasofan’s active ingredient, fluticasone propionate, is a high‑potency corticosteroid with minimal systemic absorption compared with some older agents. It offers once‑daily dosing for many patients and a favorable safety profile when used as directed, making it a common choice for allergic rhinitis and nasal polyps.

Nasofan should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid freezing the product.

Nasofan is a nasal spray. The patient gently shakes the bottle, primes it if required, tilts the head slightly forward, inserts the nozzle into one nostril, and sprays the prescribed number of sprays while breathing in gently. The process is repeated in the other nostril if instructed.

Serious risks, though rare, include adrenal suppression with prolonged high‑dose use, cataracts or glaucoma, severe allergic reactions, and nasal septal perforation. Patients should report any visual changes, persistent nosebleeds, or signs of systemic corticosteroid effects to their healthcare provider promptly.

Nasofan should be avoided in individuals with known hypersensitivity to fluticasone propionate or any component of the formulation, in children younger than two years, and in patients with active, untreated nasal infections unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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