Product image of Nasoflu (Fluticasone Propionate) supplied by GNH India

Nasoflu

Active Ingredient:
Fluticasone Propionate
Origin:
EU

Nasoflu (Fluticasone Propionate)

Fluticasone Propionate, the active ingredient in Nasoflu, is a corticosteroid presented as a nasal spray for nasal administration. It reduces inflammation in the nasal passages and is indicated for the treatment of allergic rhinitis, seasonal and perennial forms, as well as nasal polyps, in both adult and pediatric patients.

GNH India supplies Nasoflu as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution, ensuring product integrity throughout the supply chain.

Manufacturer / TM Owner

Sapiens Pharmaceuticals Ltd

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Indications & Clinical Uses

Fluticasone Propionate nasal spray is used to manage inflammatory conditions of the nasal mucosa.

  • Allergic rhinitis: reduces nasal congestion, itching and sneezing.
  • Seasonal allergic rhinitis: provides symptom relief during pollen seasons.
  • Perennial allergic rhinitis: controls year‑round nasal inflammation.
  • Nasal polyps: helps shrink polyps and improve nasal airflow.

How It Works

  • Fluticasone Propionate binds to intracellular glucocorticoid receptors in nasal epithelial cells, forming a complex that translocates to the nucleus and modulates gene transcription. This down‑regulates pro‑inflammatory cytokines, chemokines and adhesion molecules, decreasing recruitment of inflammatory cells and reducing vascular permeability, thereby suppressing the local immune response and alleviating nasal inflammation.

Side Effects

Fluticasone Propionate nasal spray may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nasal irritation: mild burning or stinging.
  • Epistaxis: occasional nosebleeds.
  • Headache: transient headache.
  • Unpleasant taste: bitter taste after use.

Serious or Rare Side Effects

  • Nasal septal perforation: rare tissue damage.
  • Glaucoma or cataract: increased intra‑ocular pressure or lens opacity with long‑term use.
  • Adrenal suppression: systemic corticosteroid effect.

Precautions & Warnings

When using Nasoflu, several precautions should be observed to ensure safety and maintain effectiveness.

  • Assess patient history: confirm no hypersensitivity to fluticasone or other steroids.
  • Avoid use in active nasal infections: postpone treatment until infection resolves.
  • Monitor for epistaxis: advise gentle nasal cleaning if bleeding occurs.
  • Use the lowest effective dose: limit exposure to reduce systemic absorption.
  • Caution in children: follow pediatric guidelines and monitor growth.
  • Store at room temperature: keep below 25°C, protect from moisture and direct sunlight.

Avoid Interactions

Fluticasone Propionate nasal spray can interact with certain medications, affecting its safety or efficacy.

Major Interactions (Avoid)

  • Ritonavir or other strong CYP3A4 inhibitors: may increase systemic exposure.
  • Systemic corticosteroids: risk of additive glucocorticoid effects.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (ketoconazole, itraconazole): may raise fluticasone levels.
  • Antihistamines: may increase nasal dryness.
  • Live vaccines: potential reduced immune response.

Frequently Asked Questions

Nasoflu, containing fluticasone propionate, is indicated for the management of allergic rhinitis—including seasonal and perennial forms—as well as for reducing the size of nasal polyps. It works by decreasing inflammation in the nasal passages, helping to relieve symptoms such as congestion, sneezing, and itching.

Fluticasone propionate binds to glucocorticoid receptors inside nasal mucosal cells. This binding alters gene transcription, leading to reduced production of inflammatory cytokines and chemokines, which diminishes immune cell infiltration and vascular permeability, thereby decreasing nasal inflammation and associated symptoms.

The appropriate dose of Nasoflu is determined by the prescribing healthcare professional based on the patient’s age, severity of symptoms, and clinical response. Patients should follow the prescriber’s instructions and the product’s labeling for the correct number of sprays per nostril.

Safety data for fluticasone propionate in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against any possible risks before prescribing Nasoflu to pregnant or nursing mothers. Patients should discuss their individual situation with a qualified professional.

To request Nasoflu, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will verify trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Nasoflu’s active ingredient, fluticasone propionate, is a high‑potency glucocorticoid with minimal systemic absorption when used as directed. Compared with older nasal steroids, it offers effective symptom control with a favorable safety profile, though individual response and tolerability can vary among patients.

Nasoflu should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and extreme heat to maintain its stability and efficacy throughout its shelf life.

Nasoflu is administered as a nasal spray. The patient gently tilts the head forward, inserts the nozzle into one nostril, and sprays the prescribed number of actuations while breathing in gently. The process is then repeated in the other nostril if required.

Serious but rare risks include nasal septal perforation, elevated intra‑ocular pressure leading to glaucoma or cataract formation, and systemic adrenal suppression with prolonged high‑dose use. Patients should report persistent nosebleeds, visual changes, or signs of systemic steroid effects to their healthcare provider promptly.

Nasoflu should be avoided in individuals with known hypersensitivity to fluticasone propionate or any component of the formulation. It is also contraindicated in patients with active untreated nasal infections until the infection is resolved, and caution is advised for those with uncontrolled glaucoma or cataracts.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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