Nasomaris 0,5 Mg/Ml (Xylometazoline Hydrochloride)

Xylometazoline Hydrochloride acts as a topical nasal decongestant to reduce swelling of the nasal mucosa.

• Common cold nasal congestion: decreases mucosal edema and improves airflow during viral upper respiratory infections.
• Sinusitis-related congestion: alleviates blockage of sinus ostia by shrinking swollen nasal tissues.
• Allergic rhinitis: reduces nasal swelling and congestion triggered by allergen exposure.

• Xylometazoline Hydrochloride is a selective alpha‑adrenergic agonist that binds to α1‑ and α2‑receptors on the smooth muscle of nasal mucosal blood vessels. Activation of these receptors induces vasoconstriction, which diminishes blood flow, reduces vascular permeability, and consequently lowers tissue edema, leading to rapid relief of nasal congestion. The effect is localized to the nasal cavity because the drug is administered topically and exhibits minimal systemic absorption, allowing a rapid onset of action within minutes.

Xylometazoline Hydrochloride may cause local and systemic adverse reactions, most of which are mild and transient.

Common Side Effects

• Burning or stinging in the nose: a transient sensation that usually resolves within minutes after application.
• Mild headache: occasional tension‑type headache that does not require medical intervention.
• Nasal dryness or crusting: reduced moisture leading to a dry, crusty lining of the nasal passages.
• Sneezing: a brief reflexive sneeze that may occur immediately following spray.

Serious or Rare Side Effects

• Elevated blood pressure: systemic vasoconstriction can raise arterial pressure, especially with overuse.
• Severe nasal irritation or ulceration: persistent pain, bleeding, or ulcer formation in the nasal mucosa.
• Allergic reactions: rash, itching, swelling of the face or throat, and in rare cases anaphylaxis.

When using Nasomaris, consider the following precautions to ensure safe and effective use.

• Age restriction: not recommended for children under 2 years without medical advice.
• Duration of use: limit to three consecutive days to avoid rebound congestion.
• Pre‑existing hypertension: use with caution and monitor blood pressure.
• Concurrent nasal surgery or trauma: avoid use until healing is complete.
• Allergic history: discontinue if signs of hypersensitivity appear.
• Store at room temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

Xylometazoline Hydrochloride can interact with certain medications and substances.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): may potentiate hypertensive effects.
• Sympathomimetic drugs (e.g., pseudoephedrine): combined vasoconstriction can raise blood pressure.
• Nasal antihistamine sprays: concurrent use may increase local irritation.

Moderate Interactions (Monitor Closely)

• Beta‑blockers: monitor for additive cardiovascular effects.
• Antihypertensive agents: may reduce efficacy of blood pressure control.
• Alcohol: can enhance dizziness or headache.