Nasomet (Mometasone Furoate)

• Nasomet, a nasal corticosteroid, acts on inflammatory pathways of the nasal mucosa to relieve allergy‑related symptoms.
• Allergic rhinitis: reduces nasal congestion, itching and sneezing by decreasing mucosal inflammation.
• Seasonal allergic rhinitis: provides symptom relief during pollen seasons through local anti‑inflammatory action.
• Perennial allergic rhinitis: controls year‑round nasal inflammation and improves airflow.
• Nasal polyps: helps shrink polyps and improves nasal patency in affected individuals.

• Mometasone furoate binds to intracellular glucocorticoid receptors in nasal epithelial cells, altering gene transcription. This down‑regulates pro‑inflammatory cytokines, chemokines and adhesion molecules, leading to reduced recruitment and activation of inflammatory cells such as eosinophils, mast cells and lymphocytes. The net effect is decreased vascular permeability and edema in the nasal mucosa.

Nasomet may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

• Nasal irritation or burning sensation
• Epistaxis (nosebleeds)
• Headache
• Throat irritation or dryness
• Cough
• Altered taste or bitter taste

Serious or Rare Side Effects

• Adrenal suppression with prolonged high‑dose use
• Cataract formation or glaucoma
• Fungal infection of the nasal mucosa
• Severe allergic reaction including anaphylaxis
• Nasal septum perforation
• Vision changes or ocular pressure increase

• Before prescribing Nasomet, consider the following precautions to ensure safe and effective use.
• Assess for active nasal or sinus infection: avoid use until infection resolved.
• Monitor intra‑ocular pressure in patients with glaucoma or cataract risk.
• Evaluate for adrenal insufficiency in patients on systemic steroids.
• Limit duration of continuous therapy: use the lowest effective dose for the shortest period.
• Use with caution in children: pediatric dosing should be determined by a physician.
• Store at room temperature: keep in the original container, protect from moisture and heat.

Nasomet can interact with other medicines; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

• Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic exposure.
• Concurrent systemic corticosteroids: heightened risk of systemic glucocorticoid effects.
• Live vaccines: nasal steroid may diminish local immune response.

Moderate Interactions (Monitor Closely)

• Azole antifungals (e.g., fluconazole): may modestly raise mometasone levels.
• Ritonavir or other protease inhibitors: potential increase in exposure.
• Nasal decongestants (e.g., oxymetazoline): may increase local irritation.