Product image of Nasonal 0,5 Mg/Ml (Xylometazoline Hydrochloride) supplied by GNH India

Nasonal 0,5 Mg/Ml

Active Ingredient:
Xylometazoline Hydrochloride
Origin:
EU

Nasonal 0,5 Mg/Ml (Xylometazoline Hydrochloride)

Xylometazoline Hydrochloride, the active ingredient in Nasonal 0,5 Mg/Ml, is an alpha-adrenergic agonist presented as a 0.5 mg/mL nasal solution for nasal use. It relieves nasal congestion associated with the common cold, sinusitis and allergic rhinitis in adults and children.

GNH India supplies Nasonal 0,5 Mg/Ml as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Jadran-Galenski Laboratorij D.D.

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Indications & Clinical Uses

Xylometazoline Hydrochloride acts on nasal mucosal blood vessels to reduce swelling and improve airflow in several common upper‑respiratory conditions.

  • Common cold nasal congestion: reduces swelling of nasal mucosa to improve breathing.
  • Sinusitis‑related congestion: alleviates blockage and pressure in the nasal passages.
  • Allergic rhinitis: decreases nasal swelling caused by allergic inflammation.

How It Works

  • Xylometazoline Hydrochloride is a topical alpha‑adrenergic agonist that binds to α1‑adrenergic receptors on the vascular smooth muscle of the nasal mucosa. This interaction triggers vasoconstriction, leading to reduced blood flow, decreased edema, and improved airway patency. Systemic absorption is minimal, allowing the effect to remain localized within the nasal cavity.

Side Effects

Nasonal may cause a range of local and systemic reactions, most of which are mild and transient.

Common Side Effects

  • Nasal irritation or burning sensation.
  • Dryness of the nasal mucosa.
  • Sneezing or mild headache.
  • Altered taste or mild throat discomfort.

Serious or Rare Side Effects

  • Rebound congestion (rhinitis medicamentosa) after prolonged use.
  • Severe hypertension or cardiovascular strain.
  • Nasal ulceration or tissue necrosis.
  • Allergic reactions including rash, swelling, or anaphylaxis.
  • Ocular irritation if the spray contacts the eyes.
  • Arrhythmias in susceptible individuals.

Precautions & Warnings

Before using Nasonal, consider the following safety measures.

  • Age limitation: avoid prolonged use in children under 6 years unless directed by a healthcare professional.
  • Duration of use: limit treatment to 3‑5 days to prevent rebound congestion.
  • Cardiovascular conditions: use with caution in patients with hypertension or heart disease.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Drug interactions: discuss all nasal or systemic decongestants with the prescriber.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nasonal can interact with other sympathomimetic agents and certain cardiovascular drugs.

Major Interactions (Avoid)

  • Oral or topical sympathomimetic decongestants: additive vasoconstriction may raise blood pressure.
  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Tricyclic antidepressants: may increase cardiovascular stimulation.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may blunt the cardiovascular response to the nasal spray.
  • Antihypertensive agents: monitor blood pressure for potential reduction.
  • Nasal corticosteroids: generally safe but monitor for local irritation.

Frequently Asked Questions

Nasonal 0,5 Mg/Ml contains Xylometazoline Hydrochloride and is indicated for the temporary relief of nasal congestion caused by the common cold, sinusitis, and allergic rhinitis. It works locally in the nasal passages to reduce swelling and improve airflow.

Xylometazoline Hydrochloride is a topical alpha‑adrenergic agonist. It binds to α1‑adrenergic receptors on nasal blood vessels, causing vasoconstriction. This reduces blood flow to the nasal mucosa, decreasing edema and allowing the nasal passages to open.

The specific dose and frequency are determined by a prescriber based on the patient’s age, condition, and response. Typically, a few sprays per nostril are used, but the exact regimen should follow the healthcare professional’s instructions.

Safety data for Xylometazoline Hydrochloride in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before using Nasonal.

To order Nasonal, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nasonal (Xylometazoline) and oxymetazoline belong to the same class of topical alpha‑adrenergic agonists and have similar onset of action. Xylometazoline may have a slightly longer duration of effect, but both carry comparable risks of rebound congestion if used beyond recommended periods.

Store Nasonal at room temperature, preferably below 25 °C, in its original packaging. Protect the container from moisture and direct sunlight. Keep the product out of reach of children and do not use if the solution appears discolored or contaminated.

Nasonal is a nasal spray intended for topical use. The prescribed number of sprays is delivered into each nostril while the head is upright. The patient should avoid blowing the nose immediately after administration to allow optimal absorption.

Serious risks include rebound nasal congestion (rhinitis medicamentosa) after prolonged use, severe hypertension, nasal ulceration, and rare allergic reactions such as anaphylaxis. If any of these occur, discontinue use and seek medical attention promptly.

Nasonal should be avoided in individuals with known hypersensitivity to Xylometazoline or any component of the formulation, in patients with severe hypertension or uncontrolled cardiovascular disease, and in children under the recommended age limit unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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