Product image of Nasonal 1 Mg/Ml (Xylometazoline Hydrochloride) supplied by GNH India

Nasonal 1 Mg/Ml

Active Ingredient:
Xylometazoline Hydrochloride
Origin:
EU

Nasonal 1 Mg/Ml (Xylometazoline Hydrochloride)

Xylometazoline Hydrochloride, the active ingredient in Nasonal 1 Mg/Ml, is an imidazoline derivative (nasal decongestant) presented as a 1 mg/mL nasal solution for nasal use. It relieves nasal congestion associated with the common cold, sinusitis, and allergic rhinitis in adults and children.

GNH India supplies Nasonal 1 Mg/Ml as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and other healthcare providers worldwide.

Manufacturer / TM Owner

Jadran-Galenski Laboratorij D.D.

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Indications & Clinical Uses

Xylometazoline Hydrochloride works as a topical nasal decongestant to reduce swelling of the nasal mucosa in several common conditions.

  • Common cold nasal congestion: reduces swelling and improves airflow.
  • Sinusitis‑related congestion: alleviates mucosal edema for better sinus drainage.
  • Allergic rhinitis: decreases nasal obstruction caused by allergic inflammation.

How It Works

  • Xylometazoline Hydrochloride acts as a selective alpha‑adrenergic agonist on the vascular smooth muscle of nasal mucosal blood vessels. Stimulation of alpha‑1 receptors produces vasoconstriction, which diminishes blood flow, reduces edema, and opens the nasal passages, thereby relieving congestion.

Side Effects

Nasal decongestants may cause local and systemic reactions, most of which are mild and reversible.

Common Side Effects

  • Nasal irritation or burning sensation.
  • Dryness of the nasal mucosa.
  • Sneezing or mild itching.
  • Headache.
  • Altered taste or bitter after‑taste.
  • Transient epistaxis (nosebleed).

Serious or Rare Side Effects

  • Severe hypertension or hypertensive crisis.
  • Cardiac arrhythmias.
  • Nasal septum perforation with prolonged misuse.
  • Anaphylactic reaction.
  • Rebound congestion (rhinitis medicamentosa) after extended use.
  • Vision disturbances (rare).

Precautions & Warnings

Before using Xylometazoline Hydrochloride, consider the following safety measures.

  • Pregnancy: safety not established; consult a healthcare professional.
  • Children under 2 years: avoid unless specifically directed by a clinician.
  • Cardiovascular disease: use with caution due to possible blood pressure effects.
  • Concomitant sympathomimetic drugs: monitor for additive cardiovascular stimulation.
  • Duration of use: limit to no more than three consecutive days to prevent rebound congestion.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Xylometazoline Hydrochloride can interact with other medications that affect the cardiovascular or sympathetic systems.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Other nasal decongestants: additive vasoconstriction may increase adverse effects.
  • Systemic sympathomimetics (e.g., pseudoephedrine): heightened cardiovascular stimulation.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: possible reduction in blood‑pressure‑lowering effect.
  • Beta‑blockers: may blunt compensatory cardiovascular responses.
  • Tricyclic antidepressants: potential additive sympathomimetic activity.

Frequently Asked Questions

Nasonal 1 Mg/Ml contains Xylometazoline Hydrochloride, a nasal decongestant used to relieve nasal blockage caused by the common cold, sinusitis, and allergic rhinitis. It works locally in the nasal passages to reduce swelling and improve airflow.

Xylometazoline Hydrochloride is a selective alpha‑adrenergic agonist. By stimulating alpha‑1 receptors on the blood vessels of the nasal mucosa, it causes vasoconstriction, which reduces blood flow, edema, and congestion, allowing the nasal passages to open.

The appropriate dose of Nasonal 1 Mg/Ml is determined by a qualified prescriber based on the patient’s age, condition, and response. Typically, a few sprays per nostril are used, but exact instructions should follow the healthcare professional’s recommendation.

Safety data for Xylometazoline Hydrochloride in pregnancy and lactation are limited. Women who are pregnant or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nasonal’s active ingredient, Xylometazoline Hydrochloride, belongs to the imidazoline class, offering rapid vasoconstriction similar to phenylephrine‑based sprays. Compared with oxymetazoline, it has a comparable onset but may have a slightly shorter duration, making it suitable for short‑term relief.

Store Nasonal 1 Mg/Ml at room temperature, below 25 °C, in its original packaging. Protect the container from moisture, direct sunlight, and extreme heat to maintain product stability.

Nasonal is a nasal solution intended for intranasal use. The prescribed number of sprays is applied into each nostril, usually while the head is upright. The patient should avoid blowing the nose immediately after administration to allow optimal absorption.

Serious risks, though rare, include severe hypertension, cardiac arrhythmias, nasal septum perforation from prolonged misuse, and anaphylactic reactions. Users should discontinue the product and seek medical attention if they experience symptoms such as a rapid rise in blood pressure, chest pain, or severe allergic signs.

Individuals with known hypersensitivity to Xylometazoline Hydrochloride or any component of the formulation should avoid use. Patients with uncontrolled hypertension, severe cardiovascular disease, or those taking MAO inhibitors should consult a healthcare professional before using the product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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