Nasonex (Mometasone Furoate)

• Nasonex, a corticosteroid nasal spray, is used to manage inflammatory conditions of the nasal passages.
• Allergic rhinitis (perennial): alleviates nasal congestion, sneezing and itching.
• Allergic rhinitis (seasonal): reduces symptoms triggered by seasonal allergens.
• Nasal polyps: decreases polyp size and improves nasal airflow.

• Mometasone furoate binds to intracellular glucocorticoid receptors in nasal mucosal cells, leading to inhibition of pro‑inflammatory cytokine gene transcription. This suppresses the activity of inflammatory cells such as eosinophils and mast cells, thereby reducing edema, mucus production, and vascular permeability in the nasal passages.

Nasonex may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

• Nasal irritation or burning
• Headache
• Epistaxis (nosebleed)
• Throat irritation
• Cough
• Unpleasant taste

Serious or Rare Side Effects

• Nasal septal perforation
• Severe allergic reaction (anaphylaxis)
• Vision changes
• Elevated intraocular pressure
• Suppression of adrenal function
• Opportunistic infections

• Before using Nasonex, consider the following precautions to ensure safe and effective therapy.
• Assess for active infections: avoid use if nasal or systemic infection is present.
• Monitor for hypersensitivity: discontinue if rash or swelling occurs.
• Use the lowest effective dose: follow prescriber instructions to minimize systemic exposure.
• Caution in patients with glaucoma or cataracts: may increase intraocular pressure.
• Avoid abrupt discontinuation: taper under medical guidance if long‑term therapy.
• Store at room temperature: keep in original container, protect from moisture and heat.

Nasonex can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

• Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase systemic corticosteroid exposure.
• Live vaccines: systemic immunosuppression may reduce vaccine efficacy.
• Systemic corticosteroids: additive risk of adrenal suppression.
• Antifungal azoles (e.g., itraconazole): may raise mometasone levels.
• Ritonavir: may increase mometasone concentrations.

Moderate Interactions (Monitor Closely)

• Nasal decongestants: may mask underlying inflammation.
• Antihistamines: additive sedation rarely.
• Diuretics: monitor electrolytes if systemic absorption occurs.
• Anticoagulants: watch for increased bleeding risk with nasal irritation.
• Herbal supplements (e.g., St. John’s wort): may alter metabolism.