Product image of Nasonex (Mometasone Furoate) supplied by GNH India

Nasonex

Active Ingredient:
Mometasone Furoate
Origin:
EU

Nasonex (Mometasone Furoate)

Mometasone furoate, the active ingredient in Nasonex, is a glucocorticoid presented as a nasal spray for nasal use. It treats allergic rhinitis and nasal polyps in adults and children.
GNH India supplies Nasonex as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

N.V. Organon

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Indications & Clinical Uses

Nasonex is a nasal corticosteroid that reduces inflammation in the upper airway.

  • Allergic rhinitis: relieves nasal congestion, sneezing, itching and rhinorrhea.
  • Nasal polyps: decreases polyp size and improves nasal airflow.
  • Seasonal allergic rhinitis: controls symptoms triggered by pollen or other seasonal allergens.

How It Works

  • Mometasone furoate binds to intracellular glucocorticoid receptors in nasal mucosal cells, altering gene transcription. This reduces the synthesis of inflammatory mediators such as prostaglandins and leukotrienes and suppresses cytokine production, leading to decreased edema, mucus formation and cellular infiltration in the nasal passages.

Side Effects

Nasonex may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nasal irritation or burning sensation
  • Headache
  • Epistaxis (nosebleed)
  • Throat irritation or dryness
  • Cough
  • Altered taste or smell

Serious or Rare Side Effects

  • Fungal infection of the nasal mucosa
  • Severe or persistent nosebleeds
  • Vision changes such as cataracts or glaucoma
  • Adrenal suppression with systemic effects
  • Anaphylactic or severe allergic reaction

Precautions & Warnings

Before prescribing Nasonex, clinicians should evaluate patient history and potential risks.

  • Hypersensitivity: avoid use in patients with known allergy to mometasone or any formulation component.
  • Nasal infection: assess and treat any active infection prior to initiating therapy.
  • Pediatric use: exercise caution in children under two years of age.
  • Systemic effects: monitor for signs of adrenal suppression with prolonged high‑dose use.
  • Concomitant nasal products: limit use of other topical nasal sprays to reduce irritation.
  • Store at room temperature: keep in the original container, protect from moisture and direct heat.

Avoid Interactions

Mometasone furoate can interact with other medications that affect corticosteroid metabolism or immune function.

Major Interactions (Avoid)

  • Systemic corticosteroids: increased risk of systemic glucocorticoid effects.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise local exposure.
  • Live vaccines: potential for reduced vaccine efficacy due to immunosuppression.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., erythromycin, ritonavir): may modestly increase exposure.
  • Other intranasal agents (decongestants, antihistamines): may increase local irritation or alter absorption.

Frequently Asked Questions

Nasonex is prescribed for allergic rhinitis, including seasonal forms, and for the management of nasal polyps. In both cases, the medication works by reducing inflammation within the nasal passages, helping to relieve congestion, sneezing, itching, and improving overall nasal airflow.

Mometasone furoate is a synthetic glucocorticoid that binds to glucocorticoid receptors in nasal mucosal cells. This binding modifies gene expression, leading to decreased production of inflammatory mediators such as cytokines, prostaglandins, and leukotrienes, which in turn reduces swelling, mucus production, and cellular infiltration.

The dose of Nasonex is individualized by the prescribing healthcare professional based on the patient’s age, severity of symptoms, and clinical response. The prescriber determines the number of sprays per nostril and the frequency of administration, typically ranging from once to twice daily.

Safety data for Nasonex in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the risks and alternatives with their healthcare provider.

To request Nasonex, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and assistance with import documentation.

Nasonex (mometasone furoate) is a high‑potency intranasal glucocorticoid with a favorable safety profile when used at recommended doses. Compared with lower‑potency agents such as fluticasone propionate, mometasone often achieves similar symptom control with fewer daily sprays, but individual response and tolerability can vary.

Nasonex should be stored at room temperature, below 25 °C (77 °F). Keep the spray bottle in its original packaging, protect it from moisture, direct sunlight and excessive heat. Do not freeze the product, and discard any remaining spray after the indicated expiration date.

Nasonex is delivered as a metered‑dose nasal spray. The patient gently shakes the bottle, primes it if it is the first use, tilts the head slightly forward, inserts the tip into one nostril, and sprays the prescribed number of actuations while breathing in gently. The process is then repeated in the other nostril if directed.

Serious risks, although rare, include fungal infection of the nasal mucosa, severe or persistent nosebleeds, visual disturbances such as cataracts or glaucoma, systemic adrenal suppression with prolonged high‑dose use, and severe allergic reactions including anaphylaxis. Patients should seek medical attention promptly if any of these occur.

Nasonex should be avoided in individuals with a known hypersensitivity to mometasone furoate or any component of the formulation. It is also contraindicated in patients with active untreated nasal infections until the infection is resolved, and it should be used with caution in children under two years of age.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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