Product image of Nasonex (Mometasone Furoate) supplied by GNH India

Nasonex

Active Ingredient:
Mometasone Furoate
Origin:
EU

Nasonex (Mometasone Furoate)

Mometasone furoate, the active ingredient in Nasonex, is a corticosteroid presented as a nasal spray for intranasal use. It is indicated for the treatment of allergic rhinitis and nasal polyps in adults and children, helping to reduce nasal inflammation and congestion.

GNH India supplies Nasonex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Organonsalud, S.L.

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Indications & Clinical Uses

  • Nasonex is a topical corticosteroid used to manage inflammatory conditions of the nasal passages.
  • Allergic rhinitis: reduces nasal congestion, sneezing and itching caused by seasonal or perennial allergens.
  • Nasal polyps: decreases polyp size and improves nasal airflow, relieving obstruction and associated symptoms.

How It Works

  • Mometasone furoate binds to intracellular glucocorticoid receptors in nasal mucosal cells, modulating gene transcription. This action suppresses the release of pro‑inflammatory cytokines, inhibits recruitment of inflammatory cells, and stabilises lysosomal membranes, resulting in reduced edema and mucus production within the nasal passages.

Side Effects

Nasonex may cause local and systemic adverse reactions.

Common Side Effects

  • Nasal irritation or burning sensation
  • Headache
  • Epistaxis (nosebleed)
  • Throat irritation or dryness
  • Cough
  • Altered taste or bitter taste

Serious or Rare Side Effects

  • Nasal septal perforation
  • Severe allergic reaction (anaphylaxis)
  • Vision changes or cataract formation
  • Adrenal suppression with prolonged high‑dose use
  • Opportunistic fungal infection of the nasal cavity

Precautions & Warnings

  • Before using Nasonex, consider the following safety measures.
  • Pregnancy: Category C; discuss potential risks with a healthcare professional.
  • Breastfeeding: Use only if the benefit outweighs potential infant exposure.
  • Recent nasal surgery or trauma: Avoid use until healing is complete.
  • Systemic corticosteroid therapy: Monitor for additive systemic effects.
  • Immunocompromised patients: Watch for increased risk of infection.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nasonex can interact with other medicines; review the following categories.

Major Interactions (Avoid)

  • Systemic corticosteroids: may increase systemic glucocorticoid exposure.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): can raise mometasone levels.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., erythromycin, fluconazole).
  • Antifungal azoles and certain antibiotics that affect steroid metabolism.
  • Live vaccines: potential reduced vaccine efficacy.
  • Herbal supplements such as St. John’s wort that induce CYP3A4.
  • Other intranasal medications: assess for additive local irritation.

Frequently Asked Questions

Nasonex is prescribed for allergic rhinitis, including seasonal and perennial forms, and for the management of nasal polyps. In both cases, the medication works locally in the nasal passages to reduce inflammation, congestion, and related symptoms.

Mometasone furoate is a synthetic glucocorticoid that binds to glucocorticoid receptors in nasal mucosal cells. This binding suppresses cytokine production, limits inflammatory cell infiltration, and stabilises cell membranes, thereby decreasing swelling and mucus formation in the nose.

The specific dose and frequency of Nasonex are determined by the prescribing clinician based on the patient’s age, condition severity, and response to therapy. Patients should follow the prescriber’s instructions and the product’s label.

Nasonex is classified as Pregnancy Category C, meaning risk cannot be ruled out. It should be used only if the potential benefit justifies the potential risk to the fetus. While limited data exist for breastfeeding, it is recommended to use the medication only when clearly needed and after consulting a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nasonex (mometasone furoate) is a high‑potency intranasal corticosteroid with a favorable safety profile when used as directed. Compared with agents such as fluticasone or budesonide, mometasone offers similar anti‑inflammatory efficacy but may have a slightly lower systemic absorption, reducing the risk of systemic side effects.

Store Nasonex at room temperature, below 25 °C (77 °F). Keep the spray in its original packaging, protect it from moisture and direct sunlight, and ensure the cap is tightly closed when not in use.

Nasonex is delivered as a metered‑dose nasal spray. The patient should gently blow the nose, insert the tip into one nostril, close the opposite nostril, and spray while breathing in gently. The recommended number of sprays per nostril is set by the prescriber.

Serious risks, though rare, include nasal septal perforation, severe allergic reactions such as anaphylaxis, adrenal suppression with prolonged high‑dose use, and opportunistic fungal infections of the nasal cavity. Patients should seek immediate medical attention if they experience unusual bleeding, severe pain, or signs of systemic infection.

Nasonex should be avoided in individuals with known hypersensitivity to mometasone furoate or any component of the formulation. It is also contraindicated in patients with active untreated nasal infections, recent nasal surgery or trauma, and those who have experienced severe adverse reactions to other intranasal corticosteroids.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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