Product image of Nasorinit (Azelastine Hydrochloride, Fluticasone Propionate) supplied by GNH India

Nasorinit

Active Ingredient:
Azelastine Hydrochloride, Fluticasone Propionate
Origin:
EU

Nasorinit (Azelastine Hydrochloride, Fluticasone Propionate)

Azelastine Hydrochloride and Fluticasone Propionate, the active ingredients in Nasorinit, are an antihistamine and a corticosteroid presented as a nasal spray for intranasal use. They are indicated for the relief of allergic rhinitis symptoms in adults and children, reducing nasal congestion, sneezing, and itching.

GNH India supplies Nasorinit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for export to EU and other markets, including batch release certificates and stability data.

Manufacturer / TM Owner

Clonmel Healthcare Ltd.

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Indications & Clinical Uses

  • Nasorinit, containing azelastine and fluticasone, is used to manage allergic rhinitis and related nasal inflammation.
  • Allergic rhinitis (seasonal): reduces nasal congestion, sneezing, and itching.
  • Perennial allergic rhinitis: controls chronic nasal symptoms and improves airflow.
  • Non‑allergic rhinitis with inflammatory component: may improve nasal patency and reduce discharge.

How It Works

  • Azelastine hydrochloride acts as a selective histamine H1‑receptor antagonist, blocking the action of histamine released during allergic reactions and thereby decreasing nasal itching, sneezing and rhinorrhea. Fluticasone propionate is a potent glucocorticoid that binds intracellular glucocorticoid receptors, modulating gene transcription to suppress the production of inflammatory cytokines, chemokines and adhesion molecules in the nasal mucosa, leading to reduced edema and mucus formation.

Side Effects

The most frequently reported reactions with Nasorinit are related to local nasal irritation and mild systemic effects.

Common Side Effects

  • Nasal irritation or burning sensation
  • Bitter or unpleasant taste
  • Headache
  • Epistaxis (nosebleed)
  • Cough or throat clearing
  • Transient nasal dryness

Serious or Rare Side Effects

  • Nasal septal perforation
  • Severe allergic reaction (anaphylaxis)
  • Vision changes or ocular pressure increase
  • Adrenal suppression with prolonged high‑dose use
  • Secondary infection of the nasal mucosa

Precautions & Warnings

  • Before prescribing Nasorinit, clinicians should consider several safety aspects.
  • Assess severity of nasal disease: ensure appropriate indication before use.
  • Recent nasal surgery or trauma: avoid use until mucosa has healed.
  • Glaucoma or cataract patients: monitor intra‑ocular pressure.
  • Pregnancy and lactation: use only if potential benefit outweighs risk.
  • Children under recommended age: follow label age restrictions.
  • Store at ambient temperature: keep below 25 °C, in original container, protected from moisture and direct sunlight.

Avoid Interactions

Nasorinit may interact with other medications that influence corticosteroid or antihistamine activity.

Major Interactions (Avoid)

  • Systemic corticosteroids: may increase risk of systemic glucocorticoid effects.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): can raise fluticasone levels.
  • Monoamine oxidase inhibitors: may potentiate antihistamine sedation.

Moderate Interactions (Monitor Closely)

  • Other intranasal decongestants: risk of rebound congestion.
  • Anticholinergic drugs: may exacerbate nasal dryness.
  • Herbal supplements containing St. John’s wort: possible induction of metabolism.

Frequently Asked Questions

Nasorinit is indicated for the treatment of allergic rhinitis, including both seasonal and perennial forms. The combination of azelastine and fluticasone helps relieve nasal congestion, sneezing, itching and rhinorrhea by targeting histamine release and inflammatory pathways in the nasal mucosa.

Azelastine hydrochloride is a selective H1‑histamine receptor antagonist. By blocking these receptors, it prevents histamine‑mediated symptoms such as itching, sneezing and watery discharge, providing rapid relief of the allergic response in the nasal passages.

The dosage of Nasorinit is determined by the prescribing healthcare professional based on the patient’s age, severity of symptoms and local labeling requirements. Patients should follow the prescriber’s instructions and the product’s package insert for the recommended number of sprays per day.

Safety in pregnancy and lactation has not been fully established. The product should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Nasorinit product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nasorinit combines an antihistamine (azelastine) with a corticosteroid (fluticasone) in a single nasal spray, offering both rapid symptom relief and anti‑inflammatory control. This dual‑action approach can be more convenient than using separate antihistamine and steroid sprays, and may provide superior symptom control for many patients.

Nasorinit should be stored at ambient temperature, preferably below 25 °C. Keep the bottle in its original packaging, protect it from moisture and direct sunlight, and ensure the cap is tightly closed when not in use to maintain product stability.

Nasorinit is administered as a nasal spray. The patient should gently blow the nose, tilt the head slightly forward, insert the nozzle into one nostril, and spray the prescribed number of sprays while breathing in gently. The process is then repeated in the other nostril if required.

Serious risks, although rare, include nasal septal perforation, severe allergic reactions such as anaphylaxis, vision changes related to intra‑ocular pressure, and systemic effects from prolonged high‑dose corticosteroid exposure such as adrenal suppression. Patients should seek immediate medical attention if any of these occur.

Nasorinit should be avoided in individuals with known hypersensitivity to azelastine, fluticasone or any excipients in the formulation. It is also contraindicated in patients who have had recent nasal surgery or trauma until healing is complete, and in children below the age specified on the product label.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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