Product image of Nasusaf (Azelastine Hydrochloride, Fluticasone Propionate) supplied by GNH India

Nasusaf

Active Ingredient:
Azelastine Hydrochloride, Fluticasone Propionate
Origin:
EU

Nasusaf (Azelastine Hydrochloride, Fluticasone Propionate)

Azelastine Hydrochloride and Fluticasone Propionate, the active ingredients in Nasusaf, are an antihistamine and corticosteroid presented as a nasal spray for nasal use. It treats seasonal and perennial allergic rhinitis and allergic nasal congestion in adults and children.

GNH India supplies Nasusaf as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Nasusaf is indicated for allergic rhinitis and related nasal congestion, acting on inflammatory and histamine pathways.

  • Seasonal allergic rhinitis: reduces sneezing, itching, rhinorrhea and nasal blockage during pollen seasons.
  • Perennial allergic rhinitis: controls year‑round symptoms caused by indoor allergens.
  • Allergic nasal congestion: alleviates swelling and mucus production to improve nasal airflow.

How It Works

  • Azelastine hydrochloride selectively blocks H1 histamine receptors on mast cells, preventing release of histamine and other mediators. Fluticasone propionate binds intracellular glucocorticoid receptors, altering gene transcription to suppress inflammatory cytokines, reducing edema and mucus formation in the nasal mucosa.

Side Effects

Nasusaf may cause local and systemic adverse reactions.

Common Side Effects

  • Nasal irritation or burning sensation
  • Headache
  • Bitter or unpleasant taste
  • Epistaxis (nosebleed)
  • Cough
  • Throat irritation

Serious or Rare Side Effects

  • Nasal septal perforation
  • Severe allergic reaction (anaphylaxis)
  • Vision changes or cataract formation
  • Profound or persistent nosebleeds
  • Adrenal suppression with prolonged high‑dose use

Precautions & Warnings

Before prescribing Nasusaf, consider the following precautions.

  • Assess diagnosis: confirm allergic rhinitis before initiating therapy.
  • Hypersensitivity: avoid in patients with known allergy to azelastine, fluticasone or formulation excipients.
  • Local irritation: monitor for persistent nasal bleeding or severe irritation.
  • Recent nasal surgery or trauma: use with caution to prevent delayed healing.
  • Pregnancy and lactation: evaluate risk‑benefit and consult a healthcare professional.
  • Store at room temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Nasusaf can interact with other medicines; review patient medication lists.

Major Interactions (Avoid)

  • Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic fluticasone exposure.
  • Monoamine oxidase inhibitors (MAOIs): can potentiate antihistamine effects and increase risk of sedation.

Moderate Interactions (Monitor Closely):\n- Concurrent intranasal corticosteroids: additive systemic steroid effect.

  • Antifungal azoles (e.g., fluconazole): may modestly raise fluticasone levels.
  • Beta‑blockers: may mask early signs of anaphylaxis.
  • Other antihistamines: may increase sedation or anticholinergic burden.

Frequently Asked Questions

Nasusaf is a prescription nasal spray that combines azelastine hydrochloride and fluticasone propionate to treat seasonal and perennial allergic rhinitis as well as allergic nasal congestion, helping to relieve sneezing, itching, runny nose and nasal blockage.

Azelastine is a selective H1‑receptor antagonist. By blocking H1 receptors on mast cells, it prevents histamine from binding, which reduces the release of histamine‑driven symptoms such as itching, sneezing and watery discharge.

The exact dosing regimen is determined by the prescribing clinician. Typically, the product is administered as one spray per nostril twice daily, but the prescriber may adjust frequency and duration based on individual patient needs.

Safety data for Nasusaf in pregnancy and lactation are limited. Healthcare providers should weigh potential benefits against possible risks and discuss any concerns with the patient before prescribing.

To request Nasusaf, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Nasusaf combines an antihistamine (azelastine) with a corticosteroid (fluticasone), offering both rapid symptom relief and anti‑inflammatory action. This dual mechanism can be more effective than monotherapy with either an antihistamine spray or a corticosteroid spray alone, especially for patients with moderate to severe symptoms.

Nasusaf should be stored at room temperature, below 25 °C, in its original packaging. Keep the bottle tightly closed, protect it from moisture and direct sunlight, and avoid freezing.

Nasusaf is a nasal spray. The patient should gently blow the nose, tilt the head slightly forward, insert the nozzle into one nostril, and press the actuator while breathing in gently. The same procedure is repeated for the other nostril.

Serious adverse events, although rare, include nasal septal perforation, severe or persistent nosebleeds, vision changes such as cataracts, and systemic allergic reactions (anaphylaxis). Patients should seek immediate medical attention if any of these occur.

Nasusaf is contraindicated in individuals with known hypersensitivity to azelastine, fluticasone, or any excipients in the formulation. It should also be avoided in patients with recent nasal surgery or trauma until healing is complete.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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