Product image of Natecal D (Colecalciferol, Calcium Carbonate) supplied by GNH India

Natecal D

Active Ingredient:
Colecalciferol, Calcium Carbonate
Origin:
EU

Natecal D (Colecalciferol, Calcium Carbonate)

Colecalciferol and Calcium carbonate, the active ingredients in Natecal D, are a vitamin D and calcium supplement presented as a tablet for oral use. It helps prevent and treat vitamin D and calcium deficiencies and supports bone health in adults and children.

GNH India supplies Natecal D as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality compliance with EU standards and reliable global distribution. The company provides regulatory documentation and supports import logistics for each market.

Manufacturer / TM Owner

Italfarmaco - Produtos Farmacêuticos, Lda.

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Indications & Clinical Uses

Natecal D is a vitamin D and calcium supplement used to address deficiencies and support bone health.

  • Vitamin D deficiency: restores adequate vitamin D levels to maintain normal calcium metabolism.
  • Calcium deficiency: supplies elemental calcium to meet dietary requirements and promote skeletal mineralization.
  • Osteoporosis prevention: supports bone mineral density and reduces the risk of fragility fractures.
  • Rickets in children: provides essential vitamin D and calcium for proper bone growth and mineralization.

How It Works

  • Colecalciferol (vitamin D3) is metabolized in the liver to 25‑hydroxyvitamin D and then in the kidney to the active 1,25‑dihydroxyvitamin D, which up‑regulates intestinal calcium and phosphate transport proteins, enhancing absorption. Calcium carbonate dissociates in the acidic gastric environment to release calcium ions that are absorbed in the small intestine and incorporated into bone matrix, contributing to skeletal strength.

Side Effects

Natecal D may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Hypercalcemia: mild elevation of serum calcium levels.
  • Gastrointestinal upset: nausea, abdominal discomfort, or constipation.
  • Flatulence and bloating.
  • Headache.
  • Mild skin rash.
  • Increased thirst.

Serious or Rare Side Effects

  • Severe hypercalcemia: may lead to cardiac arrhythmia or renal impairment.
  • Kidney stones: calcium precipitation in the urinary tract.
  • Allergic reactions: angioedema, urticaria, or anaphylaxis.
  • Hypervitaminosis D: excessive vitamin D accumulation causing systemic toxicity.
  • Acute pancreatitis: rare but reported in high calcium states.
  • Severe hypersensitivity: respiratory distress or shock.

Precautions & Warnings

Before initiating therapy with Natecal D, consider the following safety measures.

  • Baseline assessment: check serum calcium and 25‑hydroxyvitamin D levels.
  • Renal function: evaluate kidney health, especially in patients with chronic disease.
  • Hypercalcemia avoidance: do not use in individuals with known elevated calcium.
  • Caution in granulomatous diseases: sarcoidosis or tuberculosis may increase vitamin D activation.
  • Elderly dosing: monitor for falls and renal clearance.
  • Avoid concurrent high‑dose vitamin A supplements: may increase risk of hypercalcemia.
  • Store at below 25°C: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Natecal D can interact with several medicines, requiring attention to dosing and monitoring.

Major Interactions (Avoid)

  • Thiazide diuretics: may exacerbate hypercalcemia.
  • High‑dose vitamin A: combined excess can precipitate hypervitaminosis D.
  • Digoxin: elevated calcium can increase digoxin toxicity.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may alter calcium homeostasis.
  • Anticonvulsants (e.g., phenobarbital, phenytoin): increase vitamin D metabolism, reducing efficacy.
  • Systemic corticosteroids: decrease calcium absorption and may counteract supplement benefits.

Frequently Asked Questions

Natecal D is an oral nutritional supplement that provides vitamin D3 (colecalciferol) and calcium carbonate. It is used to prevent and treat vitamin D and calcium deficiencies, support normal bone metabolism, and help reduce the risk of osteoporosis or rickets in appropriate patient populations.

Colecalciferol, also known as vitamin D3, is converted in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone 1,25‑dihydroxyvitamin D. This active form binds to vitamin D receptors in intestinal cells, increasing the expression of calcium‑binding proteins and thereby enhancing calcium and phosphate absorption from the gut.

The dose of Natecal D is individualized by the prescribing healthcare professional based on the patient’s age, baseline vitamin D status, calcium needs, and clinical condition. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety of Natecal D in pregnancy or lactation has not been fully established. Healthcare providers should weigh the potential benefits against any possible risks and may recommend monitoring vitamin D and calcium levels if supplementation is considered necessary during these periods.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Natecal D. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any special handling) and the necessary import documentation.

Unlike single‑ingredient vitamin D3 products, Natecal D combines colecalciferol with calcium carbonate, offering both the hormone precursor and a calcium source in one tablet. This dual formulation can simplify regimens for patients who need both nutrients, whereas separate products require multiple pills and may have differing absorption characteristics.

Store Natecal D at temperatures below 25 °C in its original packaging. Protect the tablets from moisture, excessive heat, and direct sunlight to maintain potency and prevent degradation.

Natecal D is taken orally, usually with water. It can be swallowed with or without food, but taking it with a meal that contains some fat may improve the absorption of the vitamin D component.

The most serious risks include hypercalcemia, which can cause cardiac arrhythmias, kidney stones, or renal impairment, and rare allergic reactions such as anaphylaxis. Patients experiencing symptoms like severe nausea, vomiting, muscle weakness, or unexplained fatigue should seek medical attention promptly.

Natecal D should be avoided in individuals with known hypercalcemia, severe renal impairment, granulomatous diseases (e.g., sarcoidosis) that can increase vitamin D activation, or those who are hypersensitive to any of its ingredients. Consultation with a healthcare professional is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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