Product image of Natecal D (Colecalciferol, Calcium Carbonate) supplied by GNH India

Natecal D

Active Ingredient:
Colecalciferol, Calcium Carbonate
Origin:
EU

Natecal D (Colecalciferol, Calcium Carbonate)

Colecalciferol, the active ingredient in Natecal D, is a nutritional supplement presented as an oral tablet for oral use. It addresses calcium and vitamin D deficiencies and helps prevent osteoporosis in adults.
GNH India supplies Natecal D as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Italfarmaco S.A.

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Indications & Clinical Uses

Natecal D is used to address calcium and vitamin D related deficiencies and bone health conditions.

  • Calcium deficiency: helps restore normal calcium levels and supports bone mineralization.
  • Vitamin D deficiency: provides vitamin D3 to improve serum 25‑hydroxyvitamin D concentrations.
  • Prevention of osteoporosis: supplies calcium and vitamin D to maintain bone density and reduce fracture risk.

How It Works

  • Colecalciferol (vitamin D3) is metabolized in the liver and kidneys to its active form, calcitriol, which enhances intestinal absorption of calcium and phosphorus. Calcium carbonate supplies elemental calcium that is absorbed in the gastrointestinal tract. Together, they increase serum calcium concentrations, promote bone mineralization, and maintain calcium homeostasis.

Side Effects

Natecal D may cause adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Hypercalcemia: elevated blood calcium levels causing fatigue or mild nausea.
  • Gastrointestinal upset: including abdominal discomfort, constipation, or flatulence.
  • Nausea: occasional feeling of sickness after ingestion.
  • Diarrhea: loose stools in sensitive individuals.

Serious or Rare Side Effects

  • Hypervitaminosis D: excessive vitamin D leading to severe hypercalcemia and organ dysfunction.
  • Kidney stones: calcium precipitation in the urinary tract.
  • Allergic reactions: rash, itching, or swelling of the face, lips, or throat.
  • Cardiac arrhythmia: irregular heartbeat associated with high calcium levels.

Precautions & Warnings

Before initiating therapy with Natecal D, consider the following precautions.

  • Baseline assessment: evaluate serum calcium and vitamin D status.
  • Renal function: use with caution in patients with impaired kidney function.
  • Hypercalcemia: avoid in individuals with known high calcium levels.
  • Drug interactions: review concomitant medications that affect calcium balance.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Natecal D can interact with several medicines; awareness of the interaction level is important.

Major Interactions (Avoid)

  • Thiazide diuretics: may increase risk of hypercalcemia.
  • Vitamin A excess: combined high doses can cause hypervitaminosis D.
  • Digoxin: elevated calcium can potentiate digoxin toxicity.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may alter calcium excretion.
  • Calcium channel blockers: monitor blood pressure changes.
  • Antacids containing aluminum or magnesium: may affect calcium absorption.
  • Corticosteroids: can reduce calcium absorption and increase bone loss.

Frequently Asked Questions

Natecal D is an oral nutritional supplement that provides calcium and vitamin D3. It is used to correct calcium and vitamin D deficiencies, support normal bone mineralization, and help prevent osteoporosis in adults who need additional mineral support.

Colecalciferol, also known as vitamin D3, is converted in the liver and kidneys to its active form, calcitriol. Calcitriol binds to vitamin D receptors in the intestine, increasing the absorption of calcium and phosphorus, which are essential for bone formation and maintenance of calcium balance.

The appropriate dose of Natecal D is determined by a qualified healthcare professional based on the patient’s age, nutritional status, laboratory results, and specific clinical needs. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Natecal D in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their healthcare provider to weigh potential benefits against any possible risks.

To order Natecal D, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Natecal D combines calcium carbonate with colecalciferol, offering a cost‑effective source of elemental calcium and vitamin D3. Compared with calcium citrate formulations, calcium carbonate provides a higher calcium content per tablet but requires an acidic environment for optimal absorption, which may be less suitable for patients on proton‑pump inhibitors.

Natecal D should be stored at ambient temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Natecal D is taken orally, usually with a glass of water. It can be taken with or without food, but taking it with a meal that contains some fat may improve the absorption of the vitamin D component.

The most serious risks include hypercalcemia and hypervitaminosis D, which can lead to kidney stones, cardiac arrhythmias, or organ dysfunction. Patients should have their calcium and vitamin D levels monitored regularly, especially if they have underlying renal disease or are taking interacting medications.

Natecal D should be avoided in individuals with known hypercalcemia, severe renal impairment, or hypersensitivity to any of its ingredients. Patients with sarcoidosis or other granulomatous diseases that affect vitamin D metabolism should also consult a physician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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