Product image of Natecal D3 (Colecalciferol, Calcium Carbonate) supplied by GNH India

Natecal D3

Active Ingredient:
Colecalciferol, Calcium Carbonate
Origin:
EU

Natecal D3 (Colecalciferol, Calcium Carbonate)

Colecalciferol, the active ingredient in Natecal D3, is a vitamin D and calcium supplement presented as an oral dosage form for oral use. Together with calcium carbonate, it supplies the nutrients required for efficient calcium absorption and bone mineralisation, helping to correct calcium and vitamin D deficiencies and to reduce the risk of osteoporosis in adults and elderly patients.

GNH India supplies Natecal D3 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, including both private and public health institutions.

Manufacturer / TM Owner

Italfarmaco S.P.A

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Indications & Clinical Uses

Natecal D3 is used to address conditions related to calcium and vitamin D metabolism.

  • Calcium deficiency: helps restore normal calcium levels and supports bone health.
  • Vitamin D deficiency: provides vitamin D3 to improve serum 25‑hydroxyvitamin D concentrations.
  • Osteoporosis prevention: contributes to bone mineral density maintenance and reduces fracture risk in at‑risk populations.
  • Osteomalacia: aids in bone mineralisation in adults with insufficient vitamin D.
  • Hypocalcaemia: assists in raising serum calcium levels in patients with low calcium.

How It Works

  • Colecalciferol (vitamin D3) is hydroxylated in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone 1,25‑dihydroxyvitamin D, which binds to intracellular vitamin D receptors. This receptor activation up‑regulates transcription of calcium‑binding proteins, enhancing intestinal calcium absorption. Calcium carbonate supplies elemental calcium that is absorbed in the gastrointestinal tract, providing the substrate needed for bone mineralisation.

Side Effects

Natecal D3 may be associated with several adverse reactions, which are generally dose‑related and vary in frequency.

Common Side Effects

  • Nausea: mild gastrointestinal upset occurring shortly after ingestion.
  • Constipation: reduced bowel movements, often transient.
  • Abdominal discomfort: mild cramps or bloating.
  • Headache: occasional mild headache.
  • Dry mouth: sensation of oral dryness.

Serious or Rare Side Effects

  • Hypercalcemia: elevated blood calcium levels that can cause weakness, confusion, or cardiac arrhythmia.
  • Kidney stones: formation of calcium‑based calculi in susceptible individuals.
  • Allergic reaction: rash, itching, or swelling indicating hypersensitivity.
  • Hypervitaminosis D: excessive vitamin D leading to toxicity symptoms.
  • Cardiac arrhythmia: irregular heart rhythm in severe hypercalcemia.

Precautions & Warnings

Before using Natecal D3, consider the following precautions.

  • Renal impairment: monitor serum calcium and vitamin D levels regularly.
  • Hypercalcemia: discontinue if symptoms such as fatigue, polyuria, or nausea appear.
  • Granulomatous disease: avoid in sarcoidosis or similar conditions due to increased conversion to active vitamin D.
  • Pregnancy and lactation: use only if clearly indicated by a healthcare professional.
  • Concomitant medications: review all current drugs for potential interactions.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Natecal D3 can interact with other medicines; awareness of major and moderate interactions helps ensure safety.

Major Interactions (Avoid)

  • Thiazide diuretics: may precipitate severe hypercalcemia.
  • Vitamin A excess: increases risk of hypervitaminosis D.
  • Aluminum‑containing antacids: impair calcium carbonate absorption.

Moderate Interactions (Monitor Closely)

  • Bisphosphonates: may reduce calcium uptake if taken simultaneously.
  • Corticosteroids: may increase vitamin D metabolism, requiring monitoring of calcium and vitamin D status.

Frequently Asked Questions

Natecal D3 is an oral nutritional supplement that provides vitamin D3 (colecalciferol) and calcium carbonate. It is used to correct calcium and vitamin D deficiencies, support normal bone mineralisation, and help prevent osteoporosis in adults and elderly patients who are at risk of bone loss.

Colecalciferol (vitamin D3) is first converted in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone 1,25‑dihydroxyvitamin D. This active form binds to vitamin D receptors in intestinal cells, stimulating the production of calcium‑binding proteins that increase dietary calcium absorption and promote bone mineralisation.

The appropriate dose of Natecal D3 is determined by a qualified healthcare professional based on the individual’s age, clinical condition, laboratory results and dietary intake. Prescribers may adjust the amount to achieve target serum vitamin D levels while avoiding excess calcium intake.

Natecal D3 should be used during pregnancy or lactation only if the prescriber judges it necessary. Vitamin D and calcium are essential nutrients for fetal bone development, but excessive dosing can lead to hypercalcemia. Women should discuss any supplementation with their obstetrician or midwife.

To order Natecal D3, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Natecal D3 combines colecalciferol with calcium carbonate in a single oral formulation, offering a convenient way to address both vitamin D and calcium needs. Compared with products that contain only vitamin D or separate calcium tablets, Natecal D3 reduces pill burden and ensures coordinated dosing, which can improve adherence in patients requiring both nutrients.

Store Natecal D3 at ambient temperature, preferably below 25 °C, in the original packaging. Protect the tablets from moisture, heat and direct sunlight. Keep the container tightly closed and out of reach of children to maintain product stability and potency.

Natecal D3 is taken orally, usually with water. It can be swallowed with or without food, although taking it with a meal that contains some fat may improve vitamin D absorption. Patients should follow the dosing instructions provided by their prescriber.

The most serious risks include hypercalcemia, which may present as nausea, vomiting, weakness, confusion or cardiac arrhythmia, and rare cases of kidney stone formation. If any of these symptoms occur, the product should be discontinued and medical advice sought promptly.

Natecal D3 should be avoided in individuals with known hypersensitivity to colecalciferol, calcium carbonate or any excipients, as well as in patients with hypercalcemia, severe renal impairment, sarcoidosis or other granulomatous diseases unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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