Product image of Natispray (Glyceryl Trinitrate) supplied by GNH India

Natispray

Active Ingredient:
Glyceryl Trinitrate
Origin:
EU

Natispray (Glyceryl Trinitrate)

Glyceryl trinitrate, the active ingredient in Natispray, is an organic nitrate presented as a sublingual spray for sublingual use. It treats acute angina pectoris and is used for prophylaxis of angina attacks in adults, releasing nitric oxide to cause rapid vasodilation and lower myocardial oxygen demand.

GNH India supplies Natispray as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teofarma S.R.L.

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Indications & Clinical Uses

  • Natispray (glyceryl trinitrate) acts on the cardiovascular system to relieve myocardial ischemia.
  • Acute angina pectoris: rapid relief of chest pain during an angina episode.
  • Prophylaxis of angina attacks: prevention of recurrent angina episodes.
  • Exercise‑induced angina: reduction of symptoms during physical exertion.

How It Works

  • Glyceryl trinitrate is metabolized to nitric oxide, which activates guanylate cyclase in vascular smooth muscle cells. The resulting increase in cyclic GMP leads to relaxation of smooth muscle, causing dilation of veins and arteries, decreasing preload and afterload, and ultimately reducing myocardial oxygen consumption and alleviating anginal pain.

Side Effects

Common Side Effects

  • Headache: throbbing pain often occurring shortly after administration.
  • Flushing: warmth and redness of the face or neck.
  • Dizziness or light‑headedness: due to transient blood pressure drop.
  • Hypotension: mild to moderate reduction in blood pressure.
  • Nausea: occasional upset stomach.
  • Palpitations: awareness of heartbeat.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Syncope: fainting episodes.
  • Methemoglobinemia: rare discoloration of blood affecting oxygen delivery.
  • Reflex tachycardia: rapid heart rate in response to vasodilation.
  • Allergic reaction: rash, itching, or swelling.
  • Anaphylaxis: life‑threatening systemic allergic response.

Precautions & Warnings

Before using Natispray, consider the following precautions.

  • Severe hypotension: avoid if blood pressure is already low; monitor closely.
  • Concomitant phosphodiesterase‑5 inhibitors: contraindicated due to risk of profound hypotension.
  • Anemia or low hemoglobin: use with caution as oxygen delivery may be further compromised.
  • Patient positioning: advise sitting or lying down before administration to reduce dizziness.
  • Storage: Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Natispray may interact with several medicines.

Major Interactions (Avoid)

  • Sildenafil, tadalafil, vardenafil: combined use can cause severe hypotension.
  • Other organic nitrates (e.g., isosorbide dinitrate): additive vasodilatory effect.
  • Guanylate cyclase stimulators (e.g., riociguat): risk of excessive blood pressure fall.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (beta‑blockers, ACE inhibitors, ARBs): may enhance blood pressure‑lowering effect.
  • Diuretics: potential for additive hypotensive response.
  • Calcium channel blockers: may increase vasodilatory effect.
  • Certain antidepressants (e.g., SSRIs): monitor for dizziness or headache.

Frequently Asked Questions

Natispray contains glyceryl trinitrate and is prescribed to relieve acute angina pectoris and to prevent recurrent angina attacks in adults. It provides rapid relief of chest pain by dilating coronary vessels and reducing the heart’s oxygen demand.

Glyceryl trinitrate releases nitric oxide after sublingual absorption. Nitric oxide activates guanylate cyclase, increasing cyclic GMP levels, which relax vascular smooth muscle. This vasodilation lowers cardiac preload and afterload, decreasing myocardial oxygen consumption and alleviating angina.

The exact dose of Natispray is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and response to therapy. Dosing instructions are individualized and should be followed as written on the prescription label.

The safety of glyceryl trinitrate in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and under close medical supervision.

To order Natispray, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Natispray delivers glyceryl trinitrate via a sublingual spray, offering faster onset than oral nitrates and more convenient dosing than sublingual tablets. Compared with other nitrates, it provides precise dosing and rapid absorption, while sharing a similar safety profile and mechanism of action.

Natispray should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the spray away from extreme temperatures and ensure the cap is tightly closed to maintain potency.

Natispray is administered sublingually. The patient places the prescribed number of sprays under the tongue, holds it for a few seconds without swallowing, and allows the medication to absorb. The patient should remain seated or lying down to avoid dizziness.

The most serious risks include severe hypotension, syncope, and rare allergic reactions such as anaphylaxis. Patients should be instructed to seek immediate medical attention if they experience sudden fainting, a drastic drop in blood pressure, or signs of an allergic response.

Natispray should not be used by individuals with known hypersensitivity to glyceryl trinitrate or other organic nitrates, patients taking phosphodiesterase‑5 inhibitors, or those with severe hypotension. Contraindications must be confirmed by a healthcare professional before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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