Product image of Natribic (Sodium Hydrogen Carbonate) supplied by GNH India

Natribic

Active Ingredient:
Sodium Hydrogen Carbonate
Origin:
EU

Natribic (Sodium Hydrogen Carbonate)

Sodium Hydrogen Carbonate, the active ingredient in Natribic, is a chemical compound presented as an injectable solution for intravenous use. It functions as a systemic buffering agent to correct acid‑base disturbances, particularly metabolic acidosis, and is employed in emergency settings such as cardiac arrest. It is used under medical supervision to manage electrolyte and pH imbalances.

GNH India supplies Natribic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide, adhering to stringent quality standards and providing reliable global distribution.

Manufacturer / TM Owner

Laboratoires Sterop

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Indications & Clinical Uses

Natribic (sodium hydrogen carbonate) is used intravenously to address conditions involving acid‑base imbalance.

  • Metabolic acidosis: helps restore normal blood pH by providing bicarbonate ions.
  • Cardiac arrest: used during resuscitation to counteract acidosis and improve myocardial function.
  • Drug overdose (e.g., tricyclic antidepressants): alkalinizes serum to reduce toxicity of certain medications.

How It Works

  • Sodium hydrogen carbonate dissociates to release bicarbonate ions, which combine with hydrogen ions to form carbonic acid that is rapidly converted to water and carbon dioxide. This buffering action raises systemic pH, counteracting metabolic acidosis, and helps stabilize cellular function during acute acid‑base disturbances.

Side Effects

Sodium hydrogen carbonate may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Metabolic alkalosis: elevated blood pH causing dizziness or tingling.
  • Hypernatremia: increased sodium levels leading to thirst or hypertension.
  • Fluid overload: excess volume resulting in edema.
  • Hypokalemia: low potassium causing muscle weakness.
  • Local irritation at infusion site: redness or pain.

Serious or Rare Side Effects

  • Severe alkalosis: can lead to seizures or cardiac arrhythmias.
  • Pulmonary edema: fluid accumulation in lungs causing respiratory distress.
  • Cardiac arrhythmias: abnormal heart rhythms potentially life‑threatening.
  • Hypocalcemia: low calcium levels resulting in tetany.
  • Paradoxical intracellular acidosis: worsening acidosis despite treatment.

Precautions & Warnings

When administering Natribic, clinicians should observe several precautionary measures to ensure patient safety.

  • Assess acid‑base status: confirm metabolic acidosis before infusion.
  • Monitor electrolytes: regularly check serum sodium, potassium, and calcium.
  • Adjust dose in renal impairment: reduce volume to avoid accumulation.
  • Use cautiously in heart failure: watch for fluid overload and pulmonary edema.
  • Avoid rapid infusion in hypovolemia: infuse slowly to prevent circulatory collapse.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Sodium hydrogen carbonate can interact with other medications, affecting their efficacy or safety.

Major Interactions (Avoid)

  • Concurrent systemic alkalinizing agents: may cause excessive alkalosis.
  • Acid‑dependent drugs (e.g., ketoconazole, itraconazole): reduced absorption and effectiveness.
  • Calcium channel blockers: increased risk of hypotension when combined with rapid bicarbonate infusion.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may exacerbate hypokalemia.
  • Anticoagulants (e.g., warfarin): altered plasma protein binding, monitor INR.
  • Aspirin and other salicylates: increased ion trapping, adjust dosing.

Frequently Asked Questions

Natribic is an intravenous formulation of sodium hydrogen carbonate used to correct metabolic acidosis, support resuscitation during cardiac arrest, and mitigate toxicity in certain drug overdoses by alkalinizing the blood.

Sodium hydrogen carbonate dissociates into bicarbonate ions that combine with excess hydrogen ions, forming carbonic acid which quickly converts to water and carbon dioxide. This buffering process raises blood pH and helps restore normal acid‑base balance.

The dose of Natribic is determined by the prescribing clinician based on the patient’s acid‑base status, weight, and clinical condition. Dosing regimens are individualized and should follow established medical guidelines.

Safety data for sodium hydrogen carbonate in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order Natribic, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Natribic provides a sterile, injectable form of sodium bicarbonate, allowing rapid correction of acidosis. Compared with oral bicarbonate preparations, it offers precise dosing and immediate systemic effect, which is essential in emergency settings such as cardiac arrest or severe drug overdose.

Natribic should be stored at ambient temperature, preferably below 25 °C, in its original packaging. Protect the product from moisture and direct sunlight, and ensure the container remains sealed until use to maintain sterility.

Natribic is administered intravenously, typically diluted in compatible IV fluids. Infusion rates are adjusted according to the patient’s clinical status and laboratory results, with careful monitoring of pH, electrolytes and hemodynamics throughout the administration.

Serious risks include severe metabolic alkalosis, pulmonary edema, cardiac arrhythmias, and paradoxical intracellular acidosis. Prompt recognition of these complications and immediate medical intervention are critical to patient safety.

Natribic is contraindicated in patients with existing metabolic alkalosis, severe hypocalcemia, uncontrolled hypertension due to hypernatremia, or those with known hypersensitivity to sodium bicarbonate preparations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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