Product image of Natrii Fluoridum (18f) Synektik (Sodium Fluoride (18f)) supplied by GNH India

Natrii Fluoridum (18f) Synektik

Active Ingredient:
Sodium Fluoride (18f)
Origin:
EU

Natrii Fluoridum (18f) Synektik (Sodium Fluoride (18f))

Sodium fluoride, the active ingredient in Natrii Fluoridum (18f) Synektik, is a fluoride drug presented as an intravenous solution for intravenous use. It is employed to prevent dental caries and to correct fluoride deficiency, primarily in patients at risk of enamel demineralization.

GNH India supplies Natrii Fluoridum (18f) Synektik as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Synektik S.A.

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Indications & Clinical Uses

Natrii Fluoridum (18f) Synektik provides systemic fluoride for conditions related to dental health and fluoride deficiency.

  • Dental caries: reduces incidence by enhancing enamel remineralization.
  • Fluoride deficiency: restores systemic fluoride levels to support tooth and bone health.
  • High‑risk patients: supplies supplemental fluoride to lower decay risk in individuals with elevated caries susceptibility.

How It Works

  • After intravenous administration, sodium fluoride dissociates to release fluoride ions, which are incorporated into the hydroxyapatite lattice of tooth enamel, forming fluorapatite that is more resistant to acid dissolution. Fluoride also inhibits bacterial enolase, reducing acid production by oral microbes, and can influence bone mineralization by promoting osteoblastic activity.

Side Effects

Systemic fluoride can be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild stomach upset after infusion.
  • Vomiting: occasional emesis following administration.
  • Abdominal pain: transient discomfort in the gastrointestinal tract.
  • Metallic taste: temporary alteration in taste perception.
  • Headache: mild headache reported by some patients.
  • Injection site pain: localized discomfort at the infusion site.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Hyperfluorosis: excessive fluoride accumulation leading to skeletal or dental abnormalities.
  • Cardiac arrhythmia: irregular heart rhythm observed in rare cases.
  • Seizures: neurologic events associated with high serum fluoride levels.
  • Severe hypocalcemia: marked drop in calcium levels potentially causing tetany.

Precautions & Warnings

When using Natrii Fluoridum (18f) Synektik, several precautions should be observed to ensure safety.

  • Pregnancy: use only if clearly needed and prescribed by a qualified healthcare professional.
  • Renal impairment: monitor fluoride serum concentrations and adjust therapy as needed.
  • Pediatric use: exercise caution in children; dosage must be individualized.
  • Concurrent fluoride exposure: avoid excessive additional fluoride from dental products or supplements.
  • Allergy: discontinue immediately if signs of hypersensitivity such as rash or swelling appear.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the container.

Avoid Interactions

Fluoride may interact with certain medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Calcium supplements: can bind fluoride and diminish its systemic availability.
  • Aluminum‑containing antacids: may form insoluble complexes with fluoride, reducing absorption.
  • Thyroid hormone therapy: fluoride can interfere with thyroid function; monitor hormone levels.
  • Renal dialysis: high fluoride load may accumulate; avoid concurrent use.

Moderate Interactions (Monitor Closely)

  • Aspirin: may increase risk of gastrointestinal irritation when combined with fluoride.
  • NSAIDs: monitor renal function as both agents can affect kidney handling.
  • Bisphosphonates: concurrent use may influence bone remodeling; observe for abnormal bone turnover.

Frequently Asked Questions

Natrii Fluoridum (18f) Synektik is a systemic fluoride preparation indicated for the prevention of dental caries and for the treatment of fluoride deficiency. It is used in patients who need supplemental fluoride to strengthen tooth enamel or to correct low fluoride levels that can affect both dental and skeletal health.

Sodium fluoride dissociates after intravenous administration, releasing fluoride ions. These ions become incorporated into the crystal structure of tooth enamel, forming fluorapatite, which is more resistant to acid attack. Fluoride also inhibits bacterial enzymes that produce acid, thereby reducing demineralisation and supporting remineralisation of enamel.

The dose of Natrii Fluoridum (18f) Synektik is determined by the prescribing clinician based on the patient’s age, weight, renal function, and the specific clinical indication. Healthcare professionals calculate the appropriate amount and infusion rate to achieve the desired systemic fluoride level.

Safety in pregnancy and lactation has not been fully established. The product should be used only if the potential benefit justifies any potential risk to the fetus or infant, and it must be prescribed by a qualified healthcare professional who can evaluate the individual situation.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Unlike topical fluoride gels or toothpaste, Natrii Fluoridum (18f) Synektik delivers fluoride systemically via intravenous infusion, providing rapid and controlled serum levels. This can be advantageous for patients who cannot use oral fluoride preparations or who require immediate correction of deficiency, whereas topical agents act locally on the tooth surface.

The product should be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the solution. Before use, allow the vial to reach room temperature if required by the administration protocol, and inspect for any particulate matter or discoloration.

Natrii Fluoridum (18f) Synektik is supplied as an intravenous solution. It is administered by a qualified healthcare professional through a controlled IV infusion, following the dosage and rate prescribed by the treating physician. The infusion set and technique must comply with aseptic standards.

The most serious adverse events include anaphylactic reactions, hyperfluorosis (excessive fluoride accumulation leading to skeletal or dental abnormalities), cardiac arrhythmias, seizures, and severe hypocalcemia. Prompt recognition and medical intervention are essential if any of these events occur.

Patients with known hypersensitivity to sodium fluoride or any component of the formulation should avoid the product. It is also contraindicated in individuals with severe renal impairment, uncontrolled thyroid disorders, or those receiving dialysis without appropriate monitoring. Pregnant or breastfeeding women should use it only when clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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