Product image of Natrii Fluoridum (18f) Synektik (Sodium Fluoride (18f)) supplied by GNH India

Natrii Fluoridum (18f) Synektik

Active Ingredient:
Sodium Fluoride (18f)
Origin:
EU

Natrii Fluoridum (18f) Synektik (Sodium Fluoride (18f))

Sodium fluoride, the active ingredient in Natrii Fluoridum (18f) Synektik, is a fluoride presented as an intravenous solution for systemic use. It is employed in the prevention of dental caries and in the treatment of fluoride deficiency, particularly in patients at risk of enamel demineralisation.

GNH India supplies Natrii Fluoridum (18f) Synektik as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to strict quality standards and provides reliable logistics for global distribution efficiently.

Manufacturer / TM Owner

Synektik S.A.

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Indications & Clinical Uses

Natrii Fluoridum (Sodium Fluoride) acts within the fluoride therapeutic class to address conditions related to mineral loss in teeth.

  • Dental caries: reduces incidence of new carious lesions by enhancing enamel resistance.
  • Fluoride deficiency: restores systemic fluoride levels to support normal enamel formation.
  • Enamel demineralization: promotes remineralization of early enamel lesions and strengthens existing tooth structure.

How It Works

  • Sodium fluoride dissociates to release fluoride ions that replace hydroxide in hydroxyapatite crystals of tooth enamel, forming fluorapatite, which is more resistant to acid dissolution. The ions also inhibit bacterial glycolysis, reducing acid production, and facilitate remineralization of early enamel lesions by attracting calcium and phosphate ions to the tooth surface.

Side Effects

Adverse reactions may occur with systemic fluoride administration.

Common Side Effects

  • Nausea: mild to moderate discomfort in the stomach.
  • Vomiting: occasional expulsion of gastric contents.
  • Abdominal pain: cramping or discomfort in the abdomen.
  • Metallic taste: transient alteration in taste perception.
  • Headache: mild to moderate head pain.
  • Dizziness: sensation of light‑headedness or unsteadiness.

Serious or Rare Side Effects

  • Fluorosis: excessive fluoride leading to enamel discoloration or skeletal changes.
  • Hypocalcemia: low blood calcium levels causing muscle spasms.
  • Cardiac arrhythmia: irregular heart rhythm potentially life‑threatening.
  • Severe allergic reaction: including anaphylaxis with rash, swelling, and breathing difficulty.
  • Seizures: convulsive episodes in cases of acute toxicity.

Precautions & Warnings

When using Natrii Fluoridum, consider the following precautions.

  • Assess fluoride status: evaluate baseline serum fluoride before initiating therapy.
  • Monitor serum levels: periodic testing recommended during prolonged treatment.
  • Renal impairment: adjust use in patients with reduced kidney function.
  • Hypersensitivity: avoid in individuals with known allergy to fluoride compounds.
  • Pregnancy and lactation: safety not established; weigh risks and benefits.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Potential drug interactions should be reviewed before administration.

Major Interactions (Avoid)

  • Calcium‑containing antacids: may bind fluoride and reduce efficacy.
  • Aluminum hydroxide: forms insoluble complexes with fluoride.
  • Magnesium hydroxide: decreases fluoride absorption.

Moderate Interactions (Monitor Closely)

  • NSAIDs: combined renal effects may increase risk of kidney injury.
  • Diuretics: may alter electrolyte balance affecting fluoride handling.
  • ACE inhibitors: potential additive impact on renal function.

Frequently Asked Questions

Natrii Fluoridum (18f) Synektik is an intravenous sodium fluoride preparation used primarily for the prevention of dental caries and for treating systemic fluoride deficiency. It helps strengthen tooth enamel and supports normal mineralisation in patients at risk of demineralisation.

Sodium fluoride releases fluoride ions that become incorporated into the hydroxyapatite structure of tooth enamel, converting it to fluorapatite, which is more resistant to acid attack. The ions also inhibit bacterial metabolism in the oral cavity, reducing acid production and promoting remineralisation of early lesions.

The dosage of Natrii Fluoridum (18f) Synektik is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and serum fluoride levels. No fixed regimen is provided here; the prescriber sets the appropriate dose and infusion rate.

Safety data for Natrii Fluoridum (18f) Synektik in pregnancy and lactation are limited. The product’s pregnancy category is unknown, so clinicians must weigh potential benefits against possible risks and consider alternative therapies when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Unlike topical fluoride gels or mouth rinses that act locally, Natrii Fluoridum delivers fluoride systemically via intravenous infusion, allowing rapid elevation of serum fluoride levels. This can be advantageous in severe deficiency or when oral administration is not feasible, but it requires medical supervision and monitoring for systemic effects.

Store the product at room temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from direct light, and avoid exposure to moisture. Do not freeze the solution, and inspect the container for any signs of contamination before use.

The medication is administered intravenously by a qualified healthcare professional. It is typically infused slowly over a prescribed period, using aseptic technique and appropriate infusion equipment, to ensure controlled delivery of fluoride ions into the bloodstream.

Serious adverse events include acute fluoride toxicity leading to fluorosis, severe hypocalcemia, cardiac arrhythmias, anaphylactic reactions, and seizures. Prompt medical attention is required if any of these symptoms appear during or after infusion.

Patients with known hypersensitivity to fluoride, severe renal impairment, uncontrolled electrolyte disorders, or those who have experienced serious adverse reactions to systemic fluoride should avoid this product. Contra‑indications should be confirmed by the prescribing clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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