Product image of Natrii Iodidum [131i] Ge Healthcare (Sodium Iodide (131i)) supplied by GNH India

Natrii Iodidum [131i] Ge Healthcare

Active Ingredient:
Sodium Iodide (131i)
Origin:
EU

Natrii Iodidum [131i] Ge Healthcare (Sodium Iodide (131i))

Sodium Iodide, the active ingredient in Natrii Iodidum [131i] Ge Healthcare, is a radioactive iodine presented as an oral formulation for diagnostic and therapeutic use in thyroid conditions. It is taken up by thyroid tissue and emits radiation that can be visualized or used to ablate abnormal cells.
GNH India supplies Natrii Iodidum [131i] Ge Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Ge Healthcare Buchler Gmbh & Co. Kg

1
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Indications & Clinical Uses

Natrii Iodidum [131i] is employed in the management of thyroid‑related disorders, providing both imaging and therapeutic capabilities.

  • Thyroid imaging: enables visualization of thyroid tissue for diagnostic assessment.
  • Hyperthyroidism treatment: delivers targeted radiation to reduce excess thyroid hormone production.
  • Thyroid cancer therapy: provides ablative radiation to residual thyroid tissue after surgery.

How It Works

  • After oral administration, the sodium iodide is absorbed and preferentially taken up by thyroid cells via the sodium‑iodide symporter. The incorporated iodine‑131 emits beta particles that cause localized cellular damage, allowing imaging of thyroid tissue or therapeutic ablation of hyperfunctioning or malignant cells while sparing surrounding tissue.

Side Effects

Adverse reactions may occur following administration of radioactive iodine.

Common Side Effects

  • Nausea or mild gastrointestinal upset.
  • Transient neck discomfort or tenderness.
  • Altered taste sensation.
  • Temporary hypothyroidism.
  • Mild leukopenia.
  • Fatigue.

Serious or Rare Side Effects

  • Severe hypothyroidism requiring hormone replacement.
  • Radiation thyroiditis with pain and swelling.
  • Bone marrow suppression leading to pancytopenia.
  • Allergic reaction or anaphylaxis.
  • Pulmonary fibrosis (very rare).

Precautions & Warnings

Prior to use, several safety considerations should be observed.

  • Pregnancy: avoid unless clearly indicated, as fetal thyroid can be affected.
  • Breastfeeding: contraindicated because iodine may be secreted in milk.
  • Renal impairment: monitor renal function as excretion may be altered.
  • Baseline thyroid function: assess and monitor post‑administration levels.
  • Radiation safety: follow institutional protocols to limit exposure to staff and public.

Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Radioactive iodine can interact with other medications that affect iodine uptake or thyroid function.

Major Interactions (Avoid)

  • Thyroid hormone replacement: may reduce efficacy of radioactive iodine.
  • Antithyroid drugs (methimazole, propylthiouracil): block iodine uptake, should not be co‑administered.
  • Lithium: interferes with iodine uptake, avoid concurrent use.

Moderate Interactions (Monitor Closely)

  • Amiodarone: high iodine load may affect uptake, monitor thyroid function.
  • Corticosteroids: may modify inflammatory response, monitor patient.
  • Diuretics: can affect renal clearance of iodine, monitor renal parameters.

Frequently Asked Questions

Natrii Iodidum [131i] is a radioactive iodine preparation used primarily for thyroid imaging and for therapeutic ablation of hyperfunctioning thyroid tissue or residual thyroid cancer cells after surgery. It enables clinicians to both visualize thyroid anatomy and deliver targeted radiation where needed.

After oral ingestion, Sodium Iodide (131i) is absorbed and selectively taken up by thyroid cells via the sodium‑iodide symporter. The iodine‑131 isotope then emits beta radiation that either creates images for diagnostic purposes or destroys overactive or malignant thyroid cells while limiting exposure to surrounding tissues.

The prescribed dose of Natrii Iodidum [131i] is determined by the treating physician based on the specific clinical indication, patient weight, thyroid uptake studies, and therapeutic goals. Dosing is individualized and should follow the prescriber's instructions and relevant regulatory guidelines.

Use of radioactive iodine during pregnancy is generally avoided because it can cross the placenta and affect fetal thyroid development. It is also contraindicated while breastfeeding, as iodine can be secreted in breast milk and expose the infant to radiation. Consultation with a specialist is essential.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Compared with non‑radioactive therapies such as antithyroid drugs or surgical removal, Natrii Iodidum [131i] offers a non‑invasive option that can both diagnose and treat thyroid conditions in a single administration. It provides targeted radiation, reducing the need for repeated procedures, but requires careful patient selection and radiation safety measures.

The product should be stored at ambient temperature, below 25 °C, in its original sealed container. It must be protected from light, moisture, and any sources of contamination. Handling should follow standard radiopharmaceutical safety protocols, including use of shielding and personal protective equipment where appropriate.

Natrii Iodidum [131i] is administered orally as a single dose. The patient swallows the preparation with water, and subsequent imaging or therapeutic monitoring is performed according to the clinical protocol. No intravenous or intramuscular injection is required for this formulation.

The most serious risks include severe hypothyroidism, radiation thyroiditis, and bone marrow suppression leading to pancytopenia. Rarely, allergic reactions or pulmonary fibrosis may occur. Patients should be monitored closely for signs of these complications, and appropriate medical intervention should be initiated promptly.

Individuals who are pregnant, breastfeeding, have uncontrolled thyroid disorders, severe renal impairment, or known hypersensitivity to iodine should avoid using Natrii Iodidum [131i]. Additionally, patients currently taking antithyroid medications or lithium should not receive the product without appropriate medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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