Product image of Natrijev Klorid Alkaloid-Int (Sodium Chloride) supplied by GNH India

Natrijev Klorid Alkaloid-Int

Active Ingredient:
Sodium Chloride
Origin:
EU

Natrijev Klorid Alkaloid-Int (Sodium Chloride)

Sodium Chloride, the active ingredient in Natrijev Klorid Alkaloid-Int, is an electrolyte solution presented as an injectable solution for intravenous use. It is used to replace fluid and electrolytes in patients who require parenteral therapy.
GNH India supplies Natrijev Klorid Alkaloid-Int as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Alkaloid-Int D.O.O.

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Indications & Clinical Uses

Natrijev Klorid Alkaloid-Int, an intravenous electrolyte solution, is employed in clinical situations requiring fluid and electrolyte management.

  • Fluid replacement: restores intravascular volume in patients with dehydration, blood loss, or burns.
  • Electrolyte replenishment: provides sodium and chloride ions to correct electrolyte deficits.
  • Maintenance of plasma osmolarity: helps preserve normal plasma osmolarity during surgery or critical illness.

How It Works

  • Sodium chloride injection delivers Na+ and Cl- ions directly into the bloodstream, expanding the extracellular fluid compartment. The added sodium increases plasma osmolarity, drawing water into the vascular space, while chloride helps maintain electrical neutrality. This rapid infusion restores intravascular volume and corrects electrolyte imbalances, supporting circulatory stability and cellular function.

Side Effects

Common Side Effects

  • Hypernatremia: elevated serum sodium levels.
  • Hyperchloremia: increased serum chloride concentrations.
  • Infusion site irritation: redness or discomfort at the injection site.
  • Phlebitis: inflammation of the vein used for infusion.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Cardiac arrhythmia: abnormal heart rhythm due to electrolyte disturbances.
  • Volume overload: excessive fluid leading to pulmonary edema.
  • Severe electrolyte imbalance: can cause neurological or cardiac complications.

Precautions & Warnings

Before administration, assess the patient's fluid status and electrolyte levels.

  • Monitor serum electrolytes: regularly check sodium and chloride concentrations during therapy.
  • Adjust infusion rate in cardiac or renal disease: reduce speed to avoid fluid overload.
  • Use caution in neonates and infants: smaller volumes require precise dosing.
  • Avoid in patients with existing hypernatremia: may exacerbate condition.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Sodium chloride injection may interact with other agents affecting fluid and electrolyte balance.

Major Interactions (Avoid)

  • Hypertonic saline solutions: concurrent use can cause severe hypernatremia.
  • Potassium chloride infusions: combined administration may lead to dangerous electrolyte shifts.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increase risk of electrolyte depletion, requiring close monitoring.
  • NSAIDs: may impair renal function, affecting fluid handling.
  • Corticosteroids: can cause fluid retention, necessitating careful volume assessment.

Frequently Asked Questions

Natrijev Klorid Alkaloid-Int is an intravenous sodium chloride solution used to replace lost fluids, restore electrolyte balance, and maintain plasma osmolarity in patients who require parenteral therapy such as during surgery, trauma, or severe dehydration.

The solution provides sodium (Na+) and chloride (Cl-) ions directly into the bloodstream. These ions expand the extracellular fluid volume, increase plasma osmolarity, and help correct electrolyte deficits, thereby supporting circulatory stability and normal cellular function.

The appropriate dose is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and laboratory values. Healthcare professionals calculate the required volume and infusion rate to safely achieve the desired fluid and electrolyte goals.

Safety data for use in pregnancy or lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and it must be prescribed by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Natrijev Klorid Alkaloid-Int is a standard isotonic sodium chloride injection comparable to other 0.9% saline products. Its clinical efficacy and safety profile are similar, with differences mainly in manufacturing source, regulatory compliance, and supply chain reliability offered by GNH India.

Store the injection solution at ambient temperature, below 25 °C, in its original sealed container. Protect it from moisture, direct sunlight, and extreme temperature fluctuations. Do not freeze the product, and inspect the vial for any particulate matter before use.

The solution is administered intravenously by slow infusion or bolus, as directed by the prescriber. Administration should be performed by qualified healthcare personnel using aseptic technique, with the infusion rate adjusted to the patient’s clinical status and monitoring requirements.

Serious risks include severe hypernatremia or hyperchloremia, which can lead to neurological symptoms or cardiac arrhythmias, as well as anaphylactic reactions and volume overload causing pulmonary edema. Prompt recognition and appropriate monitoring are essential to mitigate these risks.

Patients with known hypersensitivity to sodium chloride or any component of the formulation should avoid this product. It is also contraindicated in individuals with existing severe hypernatremia or uncontrolled fluid overload, unless a clinician determines that the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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