Product image of Natrijev Klorid Fresenius Kabi (Sodium Chloride) supplied by GNH India

Natrijev Klorid Fresenius Kabi

Active Ingredient:
Sodium Chloride
Origin:
EU

Natrijev Klorid Fresenius Kabi (Sodium Chloride)

Sodium Chloride, the active ingredient in Natrijev Klorid Fresenius Kabi, is an electrolyte presented as an injection solution for intravenous use. It is employed to restore extracellular fluid volume and sodium chloride balance in patients with fluid loss, electrolyte disturbances, or low blood sodium.

GNH India supplies Natrijev Klorid Fresenius Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and oncology units worldwide. The company ensures quality compliance with EU standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Fresenius Kabi D.O.O.

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Indications & Clinical Uses

  • Natrijev Klorid is an intravenous electrolyte used to manage conditions involving fluid loss and sodium imbalance.
  • Fluid replacement: restores intravascular volume in patients with dehydration, blood loss, or burns.
  • Electrolyte replenishment: corrects sodium deficits in hyponatremic states.
  • Hypovolemia: supports circulatory volume in shock or severe fluid depletion.
  • Hyponatremia: raises serum sodium concentration to safe levels in acute or chronic cases.

How It Works

  • Intravenous sodium chloride delivers chloride and sodium ions directly into the bloodstream, increasing extracellular osmolarity. The elevated sodium concentration draws water from the intracellular space into the vascular compartment, expanding plasma volume. This osmotic shift restores hemodynamic stability and corrects hyponatremia by rebalancing the sodium‑chloride equilibrium across cell membranes.

Side Effects

Administration of sodium chloride injection may be associated with the following adverse reactions.

Common Side Effects

  • Injection site irritation: pain, redness, or swelling at the infusion site.
  • Mild hypernatremia: transient elevation of serum sodium in patients receiving large volumes.
  • Fluid overload: signs of edema or increased blood pressure in susceptible individuals.

Serious or Rare Side Effects

  • Severe hypernatremia: rapid rise in serum sodium leading to neurological symptoms.
  • Anaphylactic reaction: rare hypersensitivity causing respiratory distress or shock.
  • Electrolyte imbalance: severe shifts in potassium or calcium levels secondary to rapid infusion.

Precautions & Warnings

Before using Natrijev Klorid, consider the following precautions to ensure safe administration.

  • Assess fluid status: evaluate patient’s volume status and electrolyte levels prior to infusion.
  • Monitor serum electrolytes: check sodium and chloride concentrations regularly during therapy.
  • Adjust infusion rate: tailor the administration speed to the patient’s clinical condition and cardiac function.
  • Use aseptic technique: ensure sterile handling of the solution and infusion set.
  • Contraindications: avoid use in patients with documented hypersensitivity to sodium chloride.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Sodium chloride may interact with certain medications, influencing fluid and electrolyte balance.

Major Interactions (Avoid)

  • Hypertonic solutions: co‑administration with other hypertonic IV fluids can cause severe hypernatremia.
  • High‑dose potassium chloride: simultaneous infusion may precipitate dangerous electrolyte disturbances.
  • Loop diuretics in high doses: can lead to rapid shifts in sodium and fluid status.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may enhance risk of hyperkalemia when combined with sodium chloride therapy.
  • NSAIDs: can affect renal handling of sodium, requiring closer monitoring of fluid balance.
  • Corticosteroids: may potentiate fluid retention, necessitating observation of blood pressure.

Frequently Asked Questions

Natrijev Klorid Fresenius Kabi is an injectable sodium chloride solution indicated for intravenous fluid replacement and electrolyte replenishment. It is used to treat conditions such as hypovolemia, dehydration, and hyponatremia by restoring extracellular fluid volume and normalizing sodium‑chloride balance in patients who require rapid correction.

Sodium chloride provides sodium and chloride ions directly into the bloodstream. The added sodium raises extracellular osmolarity, drawing water from intracellular compartments into the vascular space, which expands plasma volume. This osmotic effect corrects low sodium levels and supports hemodynamic stability, helping to maintain proper cellular function and blood pressure.

The dosage of Natrijev Klorid is individualized by the prescribing clinician based on the patient’s age, weight, clinical condition, and laboratory values. The healthcare professional determines the appropriate concentration, infusion rate, and total volume required to achieve the desired fluid and electrolyte goals.

Sodium chloride is a naturally occurring electrolyte, and its use in pregnancy or lactation is generally considered safe when medically indicated. However, the decision to administer the product should be made by a qualified healthcare provider who can weigh the benefits against any potential risks to the mother and fetus or infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Natrijev Klorid Fresenius Kabi. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details—including any cold‑chain requirements—and the necessary import documentation.

Natrijev Klorid is a simple isotonic sodium chloride solution, whereas alternative IV fluids may contain additional electrolytes, glucose, or buffering agents (e.g., lactated Ringer’s or dextrose‑containing solutions). The choice depends on the patient’s specific electrolyte needs, acid‑base status, and clinical scenario; sodium chloride is preferred when pure sodium and chloride replacement is required without extra constituents.

The product should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the vial or bag in its original packaging until use, and discard any solution that appears discolored, cloudy, or contains particles.

Natrijev Klorid is given intravenously, either as a continuous infusion or a controlled bolus, according to the prescriber’s orders. The infusion set and administration equipment must be sterile, and the rate should be adjusted based on the patient’s fluid status, cardiac function, and target serum sodium level.

The most critical risks include severe hypernatremia, which can cause neurological complications, and fluid overload leading to pulmonary edema or heart failure. Rarely, anaphylactic reactions may occur. Prompt monitoring of serum electrolytes, fluid balance, and clinical signs is essential to detect and manage these serious events.

Natrijev Klorid is contraindicated in individuals with a known hypersensitivity to sodium chloride or any component of the formulation. Caution is also advised for patients with severe renal impairment, uncontrolled hypertension, or conditions predisposing them to fluid overload, where alternative fluid management strategies may be more appropriate.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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