Product image of Natrijev Klorid Hztm (Sodium Chloride) supplied by GNH India

Natrijev Klorid Hztm

Active Ingredient:
Sodium Chloride
Origin:
EU

Natrijev Klorid Hztm (Sodium Chloride)

Sodium Chloride, the active ingredient in Natrijev Klorid Hztm, is an excipient presented as an injection solution for intravenous use. It restores extracellular sodium and chloride balance and is used in fluid and electrolyte replacement and hyponatremia. GNH India supplies Natrijev Klorid Hztm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hrvatski Zavod Za Transfuzijsku Medicinu

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Indications & Clinical Uses

Sodium Chloride injection is used to address disorders of fluid and electrolyte balance.

  • Fluid and electrolyte replacement: helps restore normal extracellular fluid volume and electrolyte concentrations.
  • Hyponatremia: raises serum sodium concentration in patients with low sodium levels.
  • Perioperative fluid management: provides isotonic fluid to maintain intravascular volume during surgery.

How It Works

  • Sodium Chloride injection delivers Na+ and Cl- ions directly into the bloodstream, increasing extracellular osmolarity and expanding plasma volume. The added sodium raises serum sodium levels, while chloride contributes to acid‑base balance. This osmotic effect draws water into the intravascular compartment, correcting hyponatremia and supporting overall fluid homeostasis.

Side Effects

Adverse reactions may occur with any intravenous electrolyte solution.

Common Side Effects

  • Injection site pain: mild discomfort at the infusion site.
  • Phlebitis: inflammation of the vein used for administration.
  • Hypernatremia: elevated serum sodium if administered excessively.
  • Fluid overload: excess extracellular fluid leading to edema.

Serious or Rare Side Effects

  • Severe hypernatremia: rapid rise in sodium causing neurologic symptoms.
  • Pulmonary edema: accumulation of fluid in the lungs.
  • Anaphylaxis: severe allergic reaction with respiratory and circulatory compromise.

Precautions & Warnings

When using Sodium Chloride injection, consider the following precautions.

  • Baseline assessment: evaluate serum electrolytes and fluid status before infusion.
  • Cardiac/renal disease: adjust infusion rate in patients with heart failure or renal impairment.
  • Monitoring: continuously monitor fluid balance, weight, and vital signs during therapy.
  • Rapid correction: avoid rapid correction of chronic hyponatremia to prevent osmotic demyelination.
  • Aseptic technique: use sterile equipment to prevent infection.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Sodium Chloride injection can interact with other agents that affect fluid and electrolyte balance.

Major Interactions (Avoid)

  • Hypertonic saline: concurrent use may cause severe hypernatremia.
  • Loop diuretics: can exacerbate electrolyte shifts when combined.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: may increase fluid retention.
  • NSAIDs: can reduce renal clearance of sodium.
  • Vasopressin analogs: may alter water balance and sodium concentration.

Frequently Asked Questions

Natrijev Klorid Hztm is an injectable sodium chloride solution used primarily for fluid and electrolyte replacement and for correcting hyponatremia. It provides an isotonic source of sodium and chloride to restore extracellular fluid balance in patients who have lost fluids or have low serum sodium levels.

Sodium chloride delivers Na+ and Cl- ions directly into the bloodstream, raising extracellular osmolarity and expanding plasma volume. The increase in sodium concentration corrects hyponatremia, while chloride helps maintain acid‑base equilibrium. The osmotic shift draws water into the vascular compartment, supporting overall fluid homeostasis.

The dose of Natrijev Klorid Hztm is individualized and set by the prescribing clinician based on the patient’s electrolyte levels, fluid status, weight, and clinical condition. Healthcare professionals calculate the required volume and rate of infusion to achieve the desired therapeutic effect.

Safety data for Natrijev Klorid Hztm in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To order Natrijev Klorid Hztm, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Natrijev Klorid Hztm is a standard 0.9% sodium chloride solution, comparable to other isotonic crystalloids such as normal saline. All provide similar sodium and chloride loads, but formulation differences (e.g., preservative‑free vs. containing additives) may affect compatibility with certain medications or patient sensitivities.

Store Natrijev Klorid Hztm at ambient temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from direct light, moisture, and extreme temperatures. Do not freeze the solution, and inspect for particulate matter before use.

Natrijev Klorid Hztm is administered intravenously. It can be given as a slow infusion or a rapid bolus, depending on the clinical indication and physician orders. Proper aseptic technique and appropriate infusion sets should be used to ensure safe delivery.

Serious risks include severe hypernatremia, which can cause neurologic complications; pulmonary edema from fluid overload; and anaphylactic reactions. Prompt recognition and management of these events are essential, and patients should be closely monitored during and after infusion.

Natrijev Klorid Hztm should be avoided in patients with existing hypernatremia, severe fluid overload, uncontrolled heart failure, or advanced renal impairment unless specifically directed by a physician. Individuals with known hypersensitivity to sodium chloride solutions should also be excluded.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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