Product image of Natrilix Sr (Indapamide) supplied by GNH India

Natrilix Sr

Active Ingredient:
Indapamide
Origin:
EU

Natrilix Sr (Indapamide)

Indapamide, the active ingredient in Natrilix SR, is a thiazide‑like diuretic presented as a sustained‑release tablet for oral use. It works by promoting sodium and water excretion, thereby lowering blood pressure and decreasing fluid accumulation in patients with hypertension or edema secondary to congestive heart failure.

GNH India supplies Natrilix SR as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to quality‑assured medicines across global markets.

Manufacturer / TM Owner

Les Laboratoires Servier (Suresnes)

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Indications & Clinical Uses

Indapamide is indicated for conditions that involve elevated blood pressure or fluid overload, acting primarily on the renal distal convoluted tubule.

  • Hypertension: lowers systolic and diastolic blood pressure in patients with essential or secondary hypertension.
  • Edema associated with congestive heart failure: reduces fluid retention and improves symptomatic relief.
  • Hypertensive patients with concomitant renal impairment: provides effective blood pressure control while minimizing electrolyte disturbances.

How It Works

  • Indapamide inhibits the Na⁺/Cl⁻ cotransporter in the distal convoluted tubule of the nephron, decreasing sodium and chloride reabsorption. This leads to increased urinary excretion of sodium, chloride, and water, producing a diuretic effect. The resultant reduction in plasma volume lowers cardiac output, while a direct vasodilatory action on peripheral arterioles decreases systemic vascular resistance, together contributing to blood pressure reduction.

Side Effects

Indapamide may cause a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Electrolyte imbalance: mild hypokalemia or hyponatremia.
  • Increased urination: frequent or nocturnal urination.
  • Dizziness or light‑headedness: especially after standing.
  • Headache: mild to moderate intensity.

Serious or Rare Side Effects

  • Severe electrolyte disturbances: marked hypokalemia, hyponatremia, or hyperuricemia.
  • Acute kidney injury: sudden rise in serum creatinine.
  • Allergic reactions: rash, pruritus, or angioedema.

Precautions & Warnings

When prescribing Indapamide, clinicians should consider several safety measures to minimize risks.

  • Monitor electrolytes: check serum potassium, sodium and uric acid regularly.
  • Assess renal function: evaluate creatinine clearance before initiation and during therapy.
  • Evaluate blood pressure: ensure adequate control without excessive hypotension.
  • Caution in diabetes: monitor glucose as diuretics may affect glycemic control.
  • Avoid in severe hepatic impairment: risk of accumulation and toxicity.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and light.

Avoid Interactions

Indapamide can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Lithium: increased lithium levels may cause toxicity.
  • NSAIDs (e.g., ibuprofen, naproxen): may reduce diuretic effect and impair renal function.
  • ACE inhibitors or ARBs: combined use can precipitate severe hypotension or electrolyte imbalance.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: diuretic‑induced hypokalemia may enhance insulin sensitivity, requiring dose adjustment.
  • Antihypertensives (beta‑blockers, calcium channel blockers): additive blood pressure lowering effect.
  • Digoxin: electrolyte shifts can increase risk of digoxin toxicity.

Frequently Asked Questions

Natrilix SR contains indapamide, a thiazide‑like diuretic that is prescribed to lower high blood pressure and to reduce fluid accumulation (edema) in patients with congestive heart failure. It helps control hypertension and improves symptoms related to excess fluid retention.

Indapamide blocks the sodium‑chloride transporter in the distal convoluted tubule of the kidney, decreasing reabsorption of these ions. This promotes loss of sodium, chloride, and water in the urine, lowering plasma volume and, through a direct vasodilatory effect, reducing peripheral vascular resistance, which together lower blood pressure.

The appropriate dose of Natrilix SR is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and renal function. Dosage may be adjusted during treatment, and patients should follow the specific instructions provided by their healthcare professional.

Safety data for indapamide in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any potential risk to the fetus or infant. Healthcare providers will evaluate the risk‑benefit profile before prescribing it to pregnant or nursing women.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Natrilix SR. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Indapamide offers a combined diuretic and vasodilatory effect, which can provide effective blood pressure control with a lower incidence of certain metabolic disturbances compared with some thiazide diuretics. Its sustained‑release formulation allows once‑daily dosing, which may improve adherence relative to immediate‑release alternatives.

Store Natrilix SR tablets at ambient temperature, preferably below 25 °C. Keep them in the original packaging to protect from moisture and light. Do not store in bathrooms or near heat sources, and keep out of reach of children.

Natrilix SR is taken orally, usually once daily in the morning with or without food, as directed by a healthcare professional. Swallow the tablet whole; do not crush, split, or chew the sustained‑release tablet to maintain its intended release profile.

Serious risks include severe electrolyte disturbances such as marked hypokalemia or hyponatremia, acute kidney injury indicated by a rapid rise in serum creatinine, and rare allergic reactions like rash or angioedema. Patients should seek medical attention promptly if they experience muscle weakness, irregular heartbeat, sudden swelling, or signs of an allergic response.

Natrilix SR should be avoided in individuals with known hypersensitivity to indapamide or other sulfonamide‑derived drugs, in patients with severe hepatic impairment, and in those with uncontrolled electrolyte imbalances. Clinicians will also assess suitability in patients with severe renal dysfunction or certain cardiac conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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