Product image of Natriumbicarbonaat Viaflo Baxter (Sodium Hydrogen Carbonate) supplied by GNH India

Natriumbicarbonaat Viaflo Baxter

Active Ingredient:
Sodium Hydrogen Carbonate
Origin:
EU

Natriumbicarbonaat Viaflo Baxter (Sodium Hydrogen Carbonate)

Sodium Hydrogen Carbonate, the active ingredient in Natriumbicarbonaat Viaflo Baxter, is an excipient presented as an injectable solution for intravenous use. It supplies bicarbonate ions that help buffer systemic pH, facilitating rapid correction of acid‑base imbalances in acute care settings such as metabolic acidosis, cardiac arrest, and certain drug overdoses.

GNH India supplies Natriumbicarbonaat Viaflo Baxter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide, with the product sourced from the European Union market, and adhering to stringent quality standards.

Manufacturer / TM Owner

Baxter Sa

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Indications & Clinical Uses

Sodium Hydrogen Carbonate injection is used to address acid‑base disturbances and related emergency conditions.

  • Metabolic acidosis: restores systemic pH by increasing bicarbonate concentration.
  • Cardiac arrest with hyperkalemia: transiently raises serum pH to counteract potassium effects.
  • Drug overdose (e.g., tricyclic antidepressants): alkalinizes urine to enhance drug elimination.
  • Severe renal tubular acidosis: supports bicarbonate balance when endogenous production is insufficient.
  • Acute cyanide poisoning (as part of a protocol): provides cyanide binding capacity via conversion to thiocyanate.

How It Works

  • Sodium Hydrogen Carbonate dissociates in plasma to release bicarbonate ions, which combine with hydrogen ions to form carbonic acid that is rapidly converted to CO₂ and water. This shift in the Henderson‑Hasselbalch equilibrium raises blood pH, thereby buffering excess acidity and correcting metabolic acidosis in a physiologically rapid manner.

Side Effects

Adverse reactions may occur following intravenous administration of sodium hydrogen carbonate.

Common Side Effects

  • Injection site pain: mild discomfort at the infusion site.
  • Hypernatremia: elevated serum sodium levels.
  • Metabolic alkalosis: excessive rise in blood pH.
  • Hypokalemia: reduced serum potassium concentration.

Serious or Rare Side Effects

  • Severe alkalosis: can lead to respiratory depression.
  • Pulmonary edema: fluid accumulation in lungs.
  • Cardiac arrhythmias: irregular heart rhythms due to electrolyte shifts.
  • Anaphylactic reaction: rare but potentially life‑threatening hypersensitivity.

Precautions & Warnings

When using sodium hydrogen carbonate injection, consider the following safety measures.

  • Renal impairment: monitor serum electrolytes and acid‑base status.
  • Cardiac disease: avoid rapid large bolus in patients with coronary artery disease.
  • Respiratory disorders: use cautiously in patients with COPD.
  • Pregnancy: limited data, weigh benefits versus potential risks.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Sodium hydrogen carbonate may interact with several medications; awareness of these interactions helps maintain patient safety.

Major Interactions (Avoid)

  • Aminoglycosides: increased risk of nephrotoxicity due to altered urinary pH.
  • Calcium channel blockers: reduced efficacy in overdose treatment protocols.
  • Loop diuretics: may exacerbate electrolyte disturbances.

Moderate Interactions (Monitor Closely)

  • Potassium supplements: risk of hypokalemia when bicarbonate shifts potassium intracellularly.
  • ACE inhibitors: monitor for shifts in acid‑base balance.
  • Insulin therapy: altered glucose control due to pH changes.

Frequently Asked Questions

Natriumbicarbonaat Viaflo Baxter is an injectable sodium hydrogen carbonate solution used in clinical settings to rapidly correct acid‑base imbalances such as metabolic acidosis, to support cardiac arrest management, and to aid in the treatment of certain drug overdoses by providing bicarbonate ions that buffer excess hydrogen ions.

The compound dissociates into bicarbonate and hydrogen ions after intravenous administration. Bicarbonate combines with excess hydrogen ions to form carbonic acid, which quickly breaks down into carbon dioxide and water, thereby raising blood pH and restoring normal acid‑base balance.

The appropriate dose is determined by the prescribing clinician based on the patient’s specific condition, severity of acidosis, electrolyte status, and overall clinical picture. Dosing regimens are individualized and should follow institutional protocols or the prescriber’s orders.

Safety data for sodium hydrogen carbonate injection in pregnancy and lactation are limited. Clinicians should evaluate the potential benefits against possible risks and use the product only if clearly indicated and deemed necessary for the mother’s health.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Sodium hydrogen carbonate is the most widely used buffering agent for rapid intravenous correction of acidosis because it directly supplies bicarbonate ions. Compared with alternatives such as tromethamine, it has a well‑established safety profile, predictable pharmacokinetics, and is compatible with most infusion solutions.

The injectable solution should be stored at ambient temperature, protected from moisture and direct sunlight. Keep the vial in its original packaging until use and avoid freezing. Inspect for particulate matter or discoloration before administration.

The product is administered intravenously, either as a slow infusion or a controlled bolus, according to the prescriber’s instructions. Proper aseptic technique and appropriate infusion equipment should be used to ensure safe delivery.

Serious risks include severe metabolic alkalosis, electrolyte disturbances such as hypokalemia, pulmonary edema, cardiac arrhythmias, and rare anaphylactic reactions. Continuous monitoring of blood gases, electrolytes, and cardiovascular status is essential during and after administration.

Patients with known hypersensitivity to sodium bicarbonate, uncontrolled severe hypertension, or those in whom rapid pH shifts could exacerbate underlying conditions (e.g., severe respiratory alkalosis) should not receive this product unless a clinician determines that benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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