Product image of Natriumbicarbonat Fresenius (Sodium Hydrogen Carbonate) supplied by GNH India

Natriumbicarbonat Fresenius

Active Ingredient:
Sodium Hydrogen Carbonate
Origin:
EU

Natriumbicarbonat Fresenius (Sodium Hydrogen Carbonate)

Sodium hydrogen carbonate, the active ingredient in Natriumbicarbonat Fresenius, is an alkali presented as a sterile solution for injection for intravenous use. It is employed to correct metabolic acidosis, to aid in the treatment of severe hyperkalemia, and to alkalinize urine in selected patients.

GNH India supplies Natriumbicarbonat Fresenius as a licensed, GDP‑compliant product originating from the European Union, meeting international quality standards, providing reliable deliveries to hospitals, transplant centres, oncology centres and pharmacies and clinical research institutions worldwide.

Manufacturer / TM Owner

Fresenius Kabi Austria Gmbh

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Indications & Clinical Uses

Natriumbicarbonat Fresenius, an intravenous alkali, is used to manage disorders of acid‑base balance and related electrolyte disturbances.

  • Metabolic acidosis: restores systemic pH by supplying bicarbonate ions.
  • Severe hyperkalemia: facilitates intracellular shift of potassium by correcting acidosis.
  • Urine alkalinization: raises urinary pH to enhance excretion of certain toxins or prevent stone formation.

How It Works

  • Sodium hydrogen carbonate dissociates in plasma to yield bicarbonate ions, which combine with excess hydrogen ions to form carbonic acid that is rapidly converted to water and carbon dioxide. This buffering action raises the arterial pH, reduces hydrogen ion concentration, and indirectly promotes the movement of potassium into cells, thereby correcting acid‑base disturbances and aiding in potassium redistribution.

Side Effects

Intravenous administration of sodium bicarbonate may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Local irritation at the injection site.
  • Transient rise in blood pH (alkalemia).
  • Mild hypernatremia.
  • Fluid overload in patients with cardiac failure.

Serious or Rare Side Effects

  • Metabolic alkalosis.
  • Severe hypernatremia with neurological signs.
  • Pulmonary edema.

Precautions & Warnings

When using Natriumbicarbonat Fresenius, clinicians should observe specific precautions to ensure patient safety and product integrity.

  • Assess baseline arterial pH and bicarbonate levels: determine need for correction.
  • Monitor serum electrolytes, especially potassium and sodium: adjust infusion accordingly.
  • Infuse slowly: avoid rapid administration that may cause cardiovascular instability.
  • Use caution in patients with renal impairment or heart failure: risk of fluid and sodium overload.
  • Avoid use in untreated metabolic alkalosis: may exacerbate condition.
  • Store at controlled room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Sodium bicarbonate can interact with several medications, influencing their efficacy or safety.

Major Interactions (Avoid)

  • Calcium channel blockers: may enhance hypotensive effect.
  • Certain antibiotics (e.g., tetracyclines, fluoroquinolones): reduced absorption due to increased gastric pH.
  • Lithium: decreased renal clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Digoxin: altered serum potassium may increase risk of toxicity.
  • Anticoagulants (warfarin): changes in plasma protein binding may affect INR.
  • Insulin: rapid correction of acidosis can potentiate hypoglycemia.

Frequently Asked Questions

Natriumbicarbonat Fresenius is an intravenous sodium bicarbonate solution used to correct metabolic acidosis, to assist in the management of severe hyperkalemia, and to alkalinize urine in clinical situations such as toxin elimination or prevention of certain kidney stones.

Sodium bicarbonate dissociates into bicarbonate ions that bind excess hydrogen ions, forming carbonic acid which quickly converts to water and carbon dioxide. This buffering raises blood pH, reduces acidity, and promotes the shift of potassium into cells, helping to restore normal acid‑base balance.

The dose is individualized and determined by the prescribing clinician based on the patient’s arterial pH, bicarbonate level, body weight, and the severity of the underlying condition. No fixed regimen is provided in this description.

The pregnancy safety category for sodium bicarbonate injection is not clearly defined. It should only be used when the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and necessary import documentation.

Compared with oral sodium bicarbonate, the injectable form provides rapid systemic alkalinization and precise control in acute settings. Unlike potassium‑based alkalizers, it does not add potassium load, making it preferable when hyperkalemia is a concern. Choice depends on clinical urgency, patient renal function and electrolyte status.

Store the solution at controlled room temperature, typically below 25 °C, in its original packaging. Protect from light, moisture and extreme temperature fluctuations. Do not freeze the product and inspect the vial for particulate matter before use.

The product is administered intravenously by slow infusion through a sterile line. The infusion rate is adjusted according to the patient’s acid‑base status and cardiovascular tolerance, and the solution is mixed with compatible diluents as directed by the prescribing information.

Serious adverse events include metabolic alkalosis, severe hypernatremia that can cause neurological symptoms, and pulmonary edema due to fluid overload. Continuous monitoring of arterial blood gases, electrolytes and fluid balance is essential to detect these complications early.

Patients with untreated metabolic alkalosis, severe renal impairment that limits bicarbonate excretion, or uncontrolled heart failure with risk of fluid overload should generally avoid this therapy. Contra‑indications are determined by the treating physician based on individual clinical assessment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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