Product image of Natriumbikarbonat Abboxia (Sodium Hydrogen Carbonate) supplied by GNH India

Natriumbikarbonat Abboxia

Active Ingredient:
Sodium Hydrogen Carbonate
Origin:
EU

Natriumbikarbonat Abboxia (Sodium Hydrogen Carbonate)

Sodium bicarbonate, the active ingredient in Natriumbikarbonat Abboxia, is an electrolyte, alkalinizing agent presented as an injection solution for intravenous use. It is employed to correct metabolic acidosis, restore electrolyte balance, and alkalinize urine in clinical settings.
GNH India supplies Natriumbikarbonat Abboxia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Abboxia Ab

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Indications & Clinical Uses

  • Natriumbikarbonat Abboxia acts as an intravenous alkalinizing agent used in several metabolic and renal conditions.
  • Metabolic acidosis: restores normal systemic pH by buffering excess hydrogen ions.
  • Electrolyte imbalance correction: supplies bicarbonate to help normalize serum electrolytes.
  • Alkalinization of urine: raises urinary pH to facilitate excretion of certain toxins or improve stone dissolution.

How It Works

  • Sodium bicarbonate dissociates to provide bicarbonate ions that combine with hydrogen ions, forming carbonic acid which is then converted to carbon dioxide and water. This buffering action raises blood pH, counteracting metabolic acidosis, and increases urinary bicarbonate excretion, thereby alkalinizing urine and aiding in the correction of electrolyte disturbances.

Side Effects

Common Side Effects

  • Hypernatremia: elevated serum sodium levels.
  • Metabolic alkalosis: excessive rise in blood pH.
  • Edema: fluid retention, especially with large volumes.
  • Hypertension: increased blood pressure due to sodium load.
  • Hypokalemia: low potassium secondary to intracellular shift.
  • Infusion site irritation: redness or discomfort at injection site.

Serious or Rare Side Effects

  • Severe alkalosis leading to respiratory depression.
  • Cardiac arrhythmias from electrolyte shifts.
  • Pulmonary edema in susceptible patients.
  • Anaphylactic reactions to formulation components.
  • Severe hypernatremia causing neurological symptoms.
  • Thrombophlebitis at the infusion site.

Precautions & Warnings

  • When using Natriumbikarbonat Abboxia, clinicians should consider several safety measures.
  • Renal function: monitor creatinine and urine output.
  • Cardiac status: assess for fluid overload and hypertension.
  • Sodium load: limit use in patients with existing hypernatremia or hypertension.
  • Metabolic monitoring: avoid overcorrection of pH.
  • Pregnancy: use only if benefits outweigh potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Sodium bicarbonate can influence the activity of several co‑administered drugs.

Major Interactions (Avoid)

  • Loop diuretics: may exacerbate metabolic alkalosis.
  • ACE inhibitors: increased risk of hyperkalemia when combined with potassium‑sparing agents.
  • Certain antibiotics (e.g., quinolones): reduced absorption due to increased gastric pH.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may affect renal handling of sodium.
  • Corticosteroids: additive risk of fluid retention.
  • Antacids: cumulative alkalinizing effect.
  • Calcium channel blockers: potential alteration in plasma concentrations.
  • Digoxin: electrolyte shifts may predispose to toxicity.

Frequently Asked Questions

Natriumbikarbonat Abboxia is an intravenous sodium bicarbonate solution used to treat metabolic acidosis, correct electrolyte imbalances, and alkalinize urine in hospital settings. It provides bicarbonate ions that help restore normal acid‑base balance and support renal excretion of certain substances.

The sodium bicarbonate in Natriumbikarbonat Abboxia dissociates into bicarbonate ions, which buffer excess hydrogen ions in the blood. This buffering raises systemic pH, counteracting metabolic acidosis, and increases urinary bicarbonate excretion, thereby raising urine pH for therapeutic purposes.

The dosage of Natriumbikarbonat Abboxia is determined by the prescribing clinician based on the patient’s clinical condition, laboratory values, and response to therapy. Dosing regimens are individualized and should follow institutional protocols and the prescriber’s orders.

Safety data for Natriumbikarbonat Abboxia in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required), and necessary import documentation.

Natriumbikarbonat Abboxia delivers sodium bicarbonate directly via intravenous infusion, offering rapid correction of acid‑base disturbances. Compared with oral bicarbonate preparations, it provides faster onset, precise dosing, and is suitable for patients unable to tolerate oral intake or requiring immediate pH correction.

The product must be stored at 2‑8 °C, protected from light, and should not be frozen or shaken. Keep the vial in its original packaging until use and discard any solution that appears discolored or contains particles.

Natriumbikarbonat Abboxia is administered intravenously by a qualified healthcare professional. The solution is typically infused slowly, with the rate adjusted according to the patient’s acid‑base status, electrolyte levels, and clinical response, following the prescriber’s instructions.

Serious risks include severe metabolic alkalosis, hypernatremia, cardiac arrhythmias, pulmonary edema, and rare anaphylactic reactions. Continuous monitoring of blood pH, serum electrolytes, and fluid balance is essential to detect and manage these complications promptly.

Patients with known hypersensitivity to sodium bicarbonate or any excipients, uncontrolled hypertension, severe renal impairment, or those at high risk for fluid overload should avoid this product unless a careful risk‑benefit assessment justifies its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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