Product image of Natriumchlorid Fresenius Kabi (Sodium Chloride) supplied by GNH India

Natriumchlorid Fresenius Kabi

Active Ingredient:
Sodium Chloride
Origin:
EU

Natriumchlorid Fresenius Kabi (Sodium Chloride)

Sodium Chloride, the active ingredient in Natriumchlorid Fresenius Kabi, is an electrolyte presented as a solution for injection for intramuscular, intravenous, and subcutaneous use. It restores extracellular fluid volume and corrects sodium and chloride deficits in patients requiring fluid and electrolyte replacement, such as those with dehydration, surgical losses, or trauma.

GNH India supplies Natriumchlorid Fresenius Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and health‑care institutions worldwide. The company adheres to stringent quality standards and ensures reliable global distribution.

Manufacturer / TM Owner

Fresenius Kabi Nv/Sa

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Indications & Clinical Uses

Natriumchlorid Fresenius Kabi, a sodium chloride injection, is employed in fluid and electrolyte replacement therapy.

  • Dehydration: restores extracellular fluid volume and normalizes sodium concentration.
  • Electrolyte imbalance: replenishes chloride and sodium ions to correct hyponatremia or hypochloremia.
  • Surgical or trauma fluid loss: provides isotonic solution to maintain circulatory volume during peri‑operative care.

How It Works

  • Intravenous, intramuscular, or subcutaneous administration of sodium chloride delivers Na⁺ and Cl⁻ ions directly into the extracellular compartment. The ions increase plasma osmolality, drawing water into the vascular space, thereby expanding intravascular volume. This osmotic effect corrects hyponatremia, supports cellular function, and maintains acid‑base balance. The solution’s isotonic nature matches physiological saline concentrations, minimizing cellular shifts while providing the necessary electrolyte load.

Side Effects

Adverse reactions to Natriumchlorid Fresenius Kabi are generally related to the administration route and electrolyte shifts.

Common Side Effects

  • Injection site pain: mild discomfort at the puncture site.
  • Phlebitis: inflammation of the vein used for infusion.
  • Mild hypernatremia: transient elevation of serum sodium.
  • Transient hypertension: slight increase in blood pressure following rapid infusion.

Serious or Rare Side Effects

  • Severe hypernatremia: marked rise in serum sodium that can cause neurological symptoms.
  • Fluid overload: pulmonary edema or heart failure exacerbation in susceptible patients.
  • Allergic reaction: urticaria, bronchospasm, or anaphylaxis.
  • Electrolyte imbalance: severe hypokalemia secondary to rapid sodium correction.

Precautions & Warnings

Before using Natriumchlorid Fresenius Kabi, clinicians should consider several safety measures.

  • Assess fluid status: evaluate patient’s volume status and electrolyte profile prior to infusion.
  • Monitor serum sodium: perform regular laboratory checks during therapy.
  • Avoid in congestive heart failure: risk of fluid overload and pulmonary edema.
  • Use caution in renal impairment: reduced excretion may lead to accumulation of sodium.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Sodium chloride solution can interact with other medications affecting fluid balance or electrolyte homeostasis.

Major Interactions (Avoid)

  • Concurrent hypertonic saline: may cause severe hypernatremia.
  • Loop diuretics combined with high sodium load: risk of marked electrolyte disturbances.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may potentiate potassium changes when sodium levels shift.
  • Corticosteroids: can increase sodium retention and fluid volume.
  • Blood product transfusion: dilutional effect may alter electrolyte concentrations.

Frequently Asked Questions

Natriumchlorid Fresenius Kabi is a sterile sodium chloride solution for injection that is used to replace lost fluids and electrolytes. It is indicated in situations such as dehydration, peri‑operative fluid loss, trauma, or any condition where restoration of extracellular volume and sodium‑chloride balance is required.

Sodium chloride provides Na⁺ and Cl⁻ ions that increase plasma osmolality, drawing water into the vascular compartment. This expands intravascular volume, corrects hyponatremia, supports nerve and muscle function, and helps maintain acid‑base equilibrium. The isotonic formulation matches physiological saline, allowing safe volume expansion without causing cellular swelling.

The prescribed dose of Natriumchlorid Fresenius Kabi is determined by the treating physician based on the patient’s fluid deficit, electrolyte status, and clinical condition. Dosage is individualized and may be administered as a bolus or continuous infusion, with the rate adjusted according to laboratory monitoring and therapeutic response.

Sodium chloride is a naturally occurring electrolyte, and replacement therapy is often required in pregnancy and lactation when fluid loss occurs. However, safety information is limited, and the decision to use Natriumchlorid Fresenius Kabi should be made by a healthcare professional after evaluating the potential benefits and risks for both mother and infant.

To place an order, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details—including any cold‑chain requirements—and assists with import documentation.

Natriumchlorid Fresenius Kabi is an isotonic sodium chloride solution comparable to standard 0.9 % saline. Its composition matches physiological electrolyte concentrations, offering predictable volume expansion. Compared with hypertonic or hypotonic preparations, it provides a balanced approach for routine fluid replacement without the added risk of rapid shifts in serum sodium.

The product should be stored at ambient temperature, protected from direct sunlight and moisture, and kept in its original sealed container until use. Do not freeze the solution. Before administration, inspect the vial for particulate matter or discoloration and ensure aseptic technique during preparation.

Natriumchlorid Fresenius Kabi can be given intravenously, intramuscularly, or subcutaneously according to the clinical need. Intravenous infusion is the most common route, delivered through a sterile infusion set or syringe. The administration rate is set by the prescriber and may be adjusted based on patient response and laboratory results.

The most serious risks include severe hypernatremia, fluid overload leading to pulmonary edema or heart failure exacerbation, and rare allergic reactions such as anaphylaxis. Prompt monitoring of serum electrolytes, fluid balance, and clinical signs is essential to detect and manage these complications early.

Natriumchlorid should be used with caution or avoided in patients with uncontrolled congestive heart failure, severe renal impairment, or known hypersensitivity to sodium chloride solutions. In such cases, alternative fluid management strategies may be more appropriate, and the decision should be guided by a qualified healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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